Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for December 30, 2006

I’ve been telling my doctor for sometime now that I have some really low vitamin B deficiencies and luckily convinced him to give me a riboflavin injection. I noticed several improvements but he seems hung up on the anxiety diagnosis from the neurologist. Any research on B vitamins suggest that they all work together so if you have one deficiency, you’ll have several and my doctor didn’t seem interested in pursuing it any further.

Found this tonight from who else? Doctor Google:

Anxiety and the Vitamin B complex

Deficiencies of members of the vitamin B complex appear to be common in patients with agoraphobia (fear of open spaces). (1) The same is likely to be true for other anxiety-related conditions. We will review the evidence suggesting that individual members of this family may affect the experience of anxiety.

Inositol Supplementation

Inositol is a key intermediate of the phosphatidyl-inositol cycle, a second-messenger system used by several noradrenergic, serotonergic and cholinergic receptors. Since ingestion has been shown to raise inositol levels in the cerebrospinal fluid, this nutrient could potentially serve as an anti-anxiety agent.

Indeed, when a group of 21 patients with panic disorder either with or without agoraphobia received 12 grams daily of inositol or placebo in random order for 4 weeks each, the inositol supplement was associated with a significantly greater reduction in the frequency and severity of panic attacks and of agoraphobia than the placebo. Moreover, while the efficacy of the nutrient was judged to be comparable to that of imipramine, its side effects were minimal.

Niacinamide Supplementation

Niacinamide has been shown in an animal study to have benzodiazepine-like actions including anti-conflict, anti-aggressive, muscle relaxant and hypnotic effects. In contrast to niacin, it passes readily from the plasma to the cerebrospinal fluid where it is taken up into brain cells by a high-affinity accumulation system, suggesting it is the preferred form of vitamin B3 for the treatment of anxiety.

Lactate (which is associated with anxiety) reacts with niacinamide-adenine dinucleotide [NA[D.sub.+]] to form pyruvic acid and reduced NAD (NADH + [H.sup.+]). The equilibrium of this reaction favors lactate and NA[D.sup.+]), but it can be driven by adding excess NA[D.sup.+]. It may be that supplementation with niacinamide helps to drive the reaction, thus reducing lactate concentrations.

Anecdotal reports suggest that niacinamide has anxiolytic effects comparable to the benzodiazepines, and it may be particularly effective for patients whose anxiety is secondary to reactive hypoglycemia. Typical dosages are between 500 mg twice daily and 1,000 mg 3 times daily. Hoffer believes that the optimal daily dosage is just below the amount that produces nausea.

Thiamine Deficiency

Elevated lactate may also be caused by inadequate pyruvate dehydrogenase activity resulting from a thiamine deficiency or dependency. In that case, the conversion of pyruvate to acetyl CoA is inhibited, fostering its conversion to lactic acid. Symptoms of a prolonged moderate thiamine deficiency may include fearfulness progressing to agitation as well as emotional instability and psychosomatic complaints.

When more than 1,000 healthy young men were studied, those who were chronically borderline thiamine-deficient were currently feeling significantly more anxiety–although they were not customarily nervous individuals. There are no published studies on the repletion of a borderline thiamine deficiency to treat anxiety.

Vitamin B6 Deficiency

Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter which is involved in the regulation of anxiety, requires vitamin B6 for its synthesis; thus a deficiency of this vitamin may theoretically result in heightened anxiety. Vitamin B6 is also required for the conversion of tryptophan to serotonin, a neurotransmitter suspected of being involved in anxiety.

When over 1,000 healthy young men were studied, those found to be chronically deficient in vitamin B6 had a significantly greater tendency to become anxious, although they were not significantly more anxious at the time of the study. Also, in an open trial, patients with hyperventilation syndrome who also had abnormal xanthurenic acid excretion (an indicator of vitamin B6 deficiency) improved following the administration of pyridoxine and tryptophan, suggesting that a marginal B6 deficiency, by causing serotonin depletion, may have produced the syndrome.

Vitamin B12 Deficiency

Anxiety may be part of the neuropsychiatric syndrome seen in advanced cases of pernicious anemia which is well-known to be caused by B12 deficiency. When cobalamin levels of more than 1,000 healthy young men were studied, those who were chronically borderline vitamin B12-deficient were significantly more anxious at the time of the study–although they were not customarily nervous individuals. Whether B12 supplementation reduces anxiety when the vitamin is borderline deficient remains to be investigated.


1. Abbey LC. Agoraphobia. J Orthomol Psychiatry 11:243-59, 1982

2. Benjamin J et al. Inositol treatment in psychiatry. Psychopharmacol Bull 31(1):167-75, 1995a

3. Levine J et al. Inositol treatment raises CSF inositol levels. Brain Res 627(1):168-70, 1993

4. Benjamin J et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 15(7):1084-6, 1995b

So I’ve had a blood test for vitamin B12 and Thiamine and both were normal. Still waiting on the results from the vitamin B6 test. I’ve long discovered the Niacin deficiency with some great results but not for anxiety and Inositol I don’t know much about. I believe it’s included in B complex.

December 30, 2006 Posted by | Health | , , , , , , , | 1 Comment

Entry for August 25, 2006

Came across two interesting things today from Doctor Google:

  • Boron is essential for proper magnesium metabolism.
  • Thiamine may be critical for magnesium metabolism and possibly selenium metabolism.

Could it be possible that the reason Benfotamine has such an effect was due to the connection with magnesium? I’ve also come across something called Coenzyme Q10. Here’s what I found:

Coenzyme Q10 is a substance naturally produced by the body, but is also contained in all plant and animal foods. This coenzyme is also known as ubiquinone. Coenzyme Q10 is an essential component of the body’s process that makes the energy molecule, also known as adenosine triphosphate (ATP), from the food we eat. If coenzyme Q10 levels are compromised so is the ability of the body to make energy. All body processes depend on energy and so, ultimately, does good health. CoenzymeQ10 has also been shown to possess antioxidant properties. Both coenzyme Q10 and the mineral magnesium are key nutrients in the production process that yields the energy molecule, known as ATP (adenosine triphosphate).

Found this review on Amazon regarding a book on Mitral Valve Prolapse called “Natural Therapies for Mitral Valve Prolapse.”

“My wife suffered from mitral valve prolapse for several years until we discovered the many healing benefits of appropriate nutrient supplementation. Now that we take chelated magnesium and coenzyme Q10 daily for heart health, her MVP symptoms have disappeared. Anyone wishing verification of the role of magnesium in mitigating the symptoms of mitral valve prolapse can find it discussed in Dr. Carolyn Dean’s excellent book The Miracle of Magnesium. Another excellent book which also discusses the role of supplemental magnesium in relieving MVP is The Magnesium Factor by Dr. Mildred Seelig.”

– David Schryer

I decide to see if I can contact David to find out what the dosage was for magenesium and Q10. I’m also curious to find out how long it took. I click on his profile to get his email address and it says he’s a retired research chemist! He may be the perfect person to talk to so I send him an email.

In the meantime, I’ll need to do some more research on the magnesium metabolism…

August 25, 2006 Posted by | Health | , , , , , | Leave a comment

Entry for August 08, 2006

Here’s some more information on Dale Humpherys with a bit more detail on the actual treatment:

Since the publication of my article “Multiple Sclerosis Treated with Injectable Vitamin B1 and Liver Extract” in the TLfDP in the Feb/March 2000 issue, I have received hundreds of calls from doctors and patients wanting more information on this safe, effective, and inexpensive treatment which reverses and cures Multiple Sclerosis.

Dr. F.R. Klenner’s medical paper was published in the June and July 2000 edition of the TLfDP. Dr. H.T.R. Mount’s medical paper on the successful treatment of MS with vitamin B1 and liver extract was also published in the Feb/March 2000 issue of the TLfDP. It is interesting to note these two MDs were treating MS in the 1940s and ’50s with the same two essential ingredients — injectable B1 and liver extract, yet they were unaware of each other. Dr. Klenner in Reidsville, North Carolina and Dr. Mount in Ottawa, Ontario. Dr. Mount felt paralysis was a contraindication to his type of therapy, whereas Dr. Klenner was treating MS patients with paralysis intensively and successfully with vitamins A, C, E and all of the B vitamins and other metabolites in addition to the vitamin B1 and liver extract injections.

As many readers know, we had serious problems from 1998 on as the FDA Pharmaceutical monolith attempted to stop this treatment by refusing to allow the release of vitamin injectables and liver extract from the large labs producing them, which were under FDA control. It was a desperate situation for us and we survived by importing them from Mexico where these injectables are available without a prescription. Compounding pharmacies in the US began to produce the vitamin B1 injectables in 2000. They were able to do this because compounding pharmacies are under State control. The FDA went to court in January 2001 in New York and attempted to gain control of compounding pharmacies and they were denied that right. These pharmacies then began to produce Liver Extract also and we were assured of a reliable source of supply.

There are currently two pharmacies producing B1, 200mg per ml. and liver extract with two more coming on line, one in Canada and one in the US. With increasing numbers of patients becoming aware of this treatment, the demand will increase.

Dr. Klenner believed MS to have a viral cause. With a degree in Biochemistry he was able to understand what was happening in MS. The virus damaged the cells of the central nervous system rendering them incapable of maintaining homeostasis or normal metabolism by retaining adequate B1 within the cells, resulting in a deterioration of the myelin sheath surrounding the nerve and eventual paralysis. By raising the level of B1 in the body with a daily injection, a level could be maintained allowing normal metabolism to be continued, resulting in myelin sheath regeneration and recovery. In reality, MS is a deficiency disease caused by a viral inflammation of the central nervous system which can be reversed with adequate B1 and liver extract injections. Recovery can be enhanced with the addition of vitamins A, C, E, and B-complex and other metabolites in addition to a healthful diet and lifestyle.

I have followed this protocol for over 25 years. Following two severe attacks of MS in 1973 I could walk only a short distance and was forced to discontinue working — my doctors said I would be in a wheelchair soon. After beginning treatment with Dr. Klenner I was able to return to work within 6 months — but it was two years before I became symptom-free. I have enjoyed excellent health since.

The protocol of Dr. Klenner’s I have followed consists of: (1) a daily intramuscular injection of vitamin B1 of 300 to 400 mg. The correct dosage can be determined by the level of fatigue the patient experiences. Some patients require 300 to 400 mg daily to experience relief of fatigue symptoms. The B1 is available in a strength of 200mg per ml. So a 200 mg injection would be 1cc. Twice weekly 1cc of liver extract is added to the B1 injection so extra injections aren’t needed. The B1 injectable comes in a 30cc bottle and lasts for two to four weeks. The liver extract comes in a 10cc vial and lasts 5 weeks. The syringe is a 25 gauge by five-eighths inch 3cc syringe.

Note: B1 is not well absorbed in oral form — the daily injection is required for life for successful treatment and recovery.

Oral Vitamin Regimen

1) 5 grams daily in divided doses of Calcium Ascorbate (buffered Vitamin C) which is available in 500mg tablets. This boosts the immune system and eliminates or shortens recovery time from colds and flu.
2) Vitamin E 400 to 1000 IU daily
3) B-100 tablet. This tablet contains 100mg of all of the B vitamins.
4) B12 — One tablet (sublingual — dissolved under the tongue) daily. One to 2mg strength.
5) Niacin. Once or twice weekly, 100 to 300mg before breakfast. This is a vasodilator and opens the blood vessels allowing the nutrients to rebuild the myelin sheath damaged by MS. This will produce a flush and reddening of the skin for about 30 minutes, which most patients say they enjoy. It is advisable to lie down and cover up for the period of the flush.


A high protein diet is required to rebuild the myelin sheath. Examples: Breakfast — 1 or 2 eggs poached, with fruit and cereal. Lunch — fish and vegetables (steamed) and fruit. Supper — chicken or beef with vegetables and fruit. Soy, cheese and dairy products are a good source of protein if well tolerated.

One 500mg digestive enzyme tablet taken with each meal can often improve digestion and absorption.

Injectables are presently available at two compounding pharmacies with a prescription and are shipped to Canada and all parts of the US:

Optioncare Pharmacy, Aurora, Illinois — 630-859-0333 or 800-679-4667
College Pharmacy, Colorado Springs, Colorado — 800-888-9358

Prices at last quote:

Thiamine 200mg per ml. 30cc $15.00;
Liver Extract 10cc $25.00.

Dale Humpherys
#103 9905 5th St.
Sidney, BC V8L 2X6

Medical Journal Articles on MS

1. Multiple Sclerosis Treated with Injectable Vitamin B1 and Liver Extract, by Dale Humpherys. Issue #199/200, Feb/March 2000, TLfDP, page 58-60.

2. Multiple Sclerosis and Other Demyelinating Diseases by Dr. H.T.R. Mount, MD. Issue #199/200, Feb/March 2000, TlfDP.

3. Response of Peripheral and Central Nervous System Pathology to Mega Doses of the Vitamin B Complex and other Metabolites. Part 1 by Dr. F.R. Klenner. Issue #203, June 2000, TLfDP, page 86. Part two, Issue #204, July 2000, page 52.

4. Letters to the Editor. Injectable Liver Extract available for MS and ALS by Dale Humpherys. Issue #219, October 2001, TLfDP, pg 98.

5. The True Story of FDA Terrorism, by Dale Humpherys, TlfDP, Issue #228, July 2002, page 115.

Note to Pharmacies: When shipping to Canada, put on outside of package: “Prescription Medicine.” This is important. If “vitamins” is written on the package the patient must pay extra taxes.

August 8, 2006 Posted by | Health | , , , , | Leave a comment

Entry for August 07, 2006

Did some searching tonight for injectable vitamins and I came across this interesting story. I wonder if Benfotamine would be a help to him instead of the daily injections?

Multiple Sclerosis Treated with Injectable Vitamin B1 & Liver Extract

Originally published in TOWNSEND LETTER for DOCTORS & PATIENTS, February/March 2000

This is a case history of a recovery from a disease which exacts a terrible price in suffering and hardship from its victims and their families and for which orthodox medicine stubbornly insists there is no successful treatment.

MS has been reversed and cured by two doctors working independently and apparently unaware of each other since the 1940s. These two men were Dr. F.R. Klenner, MD of Reidsville, North Carolina and Dr. H.T.R. Mount, MD of Ottawa, Ontario. Dr. Klenner makes this claim in his medical paper “Response of Peripheral and Central Nerve Pathology to Mega-doses of the Vitamin B-Complex and other Metabolites,” in the Journal of Applied Nutrition, fall 1973. “Any victim of MS who will dramatically flush with the use of nicotinic acid and who has not yet progressed to the stage of myelin degeneration, as witnessed by sustained ankle clonus elicited in the orthodox manner, can be cured with the adequate employment of thiamin HCL and other factors of the vitamin B complex in conjunction with essential proteins, lipids, carbohydrates and injectable Liver Extract. If sustained ankle clonus is not B1 lateral, then it is not a deterrent. We have had patients who did demonstrate B1 lateral sustained ankle clonus, and who were in wheelchairs, and who returned to normal activities after 5 to 8 years of treatment.” To cure MS is a dramatic claim to make for a disease which supposedly has no successful treatment. Dr. Klenner’s results speak for themselves.

Dr. Mount on the other hand, describes his patients as “clinically well” or “clinically improved.” For my part, MS is a brutal disease and anyone who has had it will have a reminder of it until the end of their days. The symptom that has remained with me is the heaviness in the feet when over-tired. I am otherwise symptom-free. I received many calls from doctors after my story was published and their comments during the first 5 or 10 years were “you are in remission.” Now in my 25th year I don’t hear that “remission” bit any more. Am I cured or in remission? As long as I take my intramuscular injection of B1 200 mg daily and my 2cc liver extract weekly I am completely well. Call it what you wish!

I was diagnosed in 1972 at the age of 44 and treated with a series of ACTH injections. I seemed to recover but still had extreme fatigue and numbness in my feet and legs which slowly improved. I continued to work at my profession as a teacher. In 1973 I had a second attack which was more severe, affecting my legs and arms and the fatigue forced me to quit work. I was able to be up for several hours at a time but had to spend most of my time in bed. I was again given ACTH injections which didn’t seem to have any effect. My GP and neurologist had no other treatment to offer.

They tried to encourage me by telling of the research being done on MS which was progressing rapidly and eventually would produce a drug which would cure MS, they assured me. While waiting for this cure to be discovered, I began to read extensively everything I could on MS. The exciting moment for me came when I was reading a book called How to Get Well by Dr. Paavo Airola, ND in which he said that Klenner was treating MS with much success.

After talking it over with my family I decided to go down to Reidsville, North Carolina, to see Dr. Klenner. I believed my doctors would be happy to hear this news, but when I told them they were silent and finally said, “Dale, this man Klenner is a quack — he will take your money and give you false hope. If there were a successful treatment for MS we would know about it — Don’t go.”

Thank God I ignored this medical advice.

I phoned Dr. Klenner’s office and was told by his receptionist that he didn’t book appointments but that I should come down and he would see me. This sounded strange to me — no appointment? But I booked a flight from Victoria, British ColumB1a to Reidsville, North Carolina. A long flight. Fear tugged at my heart — could I make it? I could walk only a short distance and was suffering total fatigue. When I arrived at the small town of Reidsville at 1:00 p.m. I phoned Dr. Klenner’s office and was told to come to his office at 5:00 p.m. When I arrived there was a group of perhaps 25 people standing at the bottom of a flight of stairs leading up to his office on the 2nd floor of an old frame building. They told me they were waiting to get their name on the patient list for the next day. Presently Dr. Klenner’s receptionist appeared and tacked a piece of paper to the door. This paper had 20 numbers on it. If you were fortunate you got your name on the list which were the 20 patients Dr. Klenner would see the next day. I was fortunate and met him the following day. He was working alone with his wife who was an RN and a receptionist. I learned that his receptionist had come to him in a wheelchair with MS in 1961 — she was now completely recovered and worked several days a week in his office.

Dr. Klenner examined me and confirmed the diagnosis of MS while explaining to me how the treatment worked. He said I was fortunate to come to him while still on my feet as the recovery period would be shortened considerably. I received an injection of B1 and liver extract and a copy of his protocol which I was to read that night. I saw him again the next morning and was shown how to give myself intramuscular injections and told where to order the injectables. His final words to me were that I would recover completely and could probably go back to work within a matter of months. The fatigue I had suffered for 2 years was gone after the first several injections. I couldn’t believe it. I was still weak with numbness in my feet and legs but I had my strength again. Before I left, his wife cautioned me that I must have the daily injection for life because the B1 cannot be absorbed orally in pill form.

When I was ready to leave I asked Mrs. Klenner for my bill — she said it wasn’t made up yet and they would send it to me. I never did receive a bill from Dr. Klenner — so much for the quack who would take my money in return for false hope!

When I arrived home, putting Dr. Klenner’s full treatment schedule in effect proved to be a problem. Many of the oral medications weren’t available in Canada and some of these medications such as niacin caused me some stomach distress. I shall always be grateful to Dr. Abram Hoffer who guided me through this period. Dr. Hoffer was practicing in Saskatoon, Saskatchewan at that time but he always took my many telephone calls with the grace and compassion this great physician is renowned for. Dr. Hoffer has been practicing here in Victoria for quite some time and I had occasion to see him at his office recently about a problem I was having. I presented him with a sheet of the supplements I am presently taking and he said, “Dale, this must cost you a bundle but you’ll probably live to be a hundred.” Recalling what last month’s� B1ll for supplements had been, I replied that I probably couldn’t afford to.

Several years later following an interview for CBC television broadcast nationwide, I received a call from a man in Toronto who told me he had been cured of MS by Dr. H.T.R. Mount, MD of Ottawa, Ontario. This was very interesting as I was unaware anyone else was treating MS. He sent me a copy of a medical paper which appeared in the Canadian Medical Association Journal June 2nd, 1973 in which he gives 14 case histories of MS patients treated successfully. On reading this paper I was surprised to find Dr. Mount was using B1 intravenously and liver extract intramuscularly and nothing else! Dr. Klenner was treating MS intensively with vitamins A, C, E, and all of the B vitamins and other metabolites in addition to the B1 and liver extract injections. Dr. Mount felt paralysis was a contraindication to his type of therapy whereas Dr. Klenner was treating patients with paralysis with success. Dr. Mount concludes his medical paper with a call for detailed studies to enlarge its use or to circumscribe its limitations.

Why have the positive results of these two men been stonewalled by orthodox medicine for 50 years? To answer this question let’s begin with the patient who goes to his GP with neurological symptoms suggestive of MS as I did. He is then referred to a neurologist for treatment. The neurologist gives the patient steroids, usually cortisone or ACTH which do not work. This is the stage at which this patient should be treated with intramuscular injections of Bl and liver extract. Would this safe, easily administered and economical treatment work with every patient? Perhaps and perhaps not. Would it work with 8 out of 10— 5 out of 10— 1 out of 10? Cortisone with ACTH produces 0 out of 10 results, so even 1 out of 10 is a win-win situation.

It is obvious that our neurologist, who is an “advisor” to the MS Society and probably receives a stipend thereof and who probably received a grant to do research work on a cause or cure for MS at one time during or following his medical education, won’t rock the boat by using a treatment that works. This would risk the whole financial structure salaries and grants funded with public money. This is called Empire Building. When did we become a society that victimizes its most vulnerable citizens? We are seeing the same sordid situation in the Cancer industry and with the alternative therapy treatments that threaten the medical status quo.

Of great concern to patients on this treatment has been the lack of readily available supplies of injectables, thiamine 100mg per ml in 30 ml bottles and liver extract in 30 ml bottles. In Canada the Canada Health Protection Branch (the Canadian version of the FDA) wouldn’t allow pharmacies to import thiamine and liver extract which were not produced here. Patients had to import their supplies from the US with all the red tape this entailed. Most pharmacies in the US didn’t stock these supplies because of the limited demand and had to order them from suppliers. This lack of a readily available supply was a hardship for patients and many finally became discouraged and gave up.

Steris Laboratories of Phoenix, Arizona was the sole manufacturer of vitamin and liver extract injectables in the US. Two years ago the cold heavy hand of the FDA fell on Steris Labs and they were forced to stop producing vitamin injectables. This has been a tragedy for MS patients and I have received many calls from desperate people asking for help. With the FDA’s record of crackdowns on nutritional therapies and supplements, was this an orchestrated plan to eliminate one more threat to orthodox medicine (neurologists et al.) from alternative therapies? I have every reason to believe it was.

Three years ago, Merit Pharmaceuticals of Los Angeles began producing liver extract. When I learned in 1998 what had happened at Steris, I called Charles Fahr, president of Merit Labs, and asked him if he could begin producing thiamin injectable in 30 ml, 100mg per ml. He said he was considering it and would probably start in August if things looked favorable. In January of 1999 I was informed by my pharmacist in the US that thiamine was still not available. I phoned Mr. Fahr again and he said they had decided to produce a 3Oml B Complex 100 injectable which had a formulation of thiamin 100mg per ml, B6, 2mg per ml, Pantothenate 2mg per ml, B2, 2mg per ml and niacinamide 100mg per ml. I asked why the thiamin wasn’t being produced and he said he felt that the market for thiamin had been killed by the FDA action but thought that the B-complex 100 would appeal to a broader market as many doctors routinely use a B-complex injection for their patients. This was good news for us as this formula supplied the 100mg of thiamin required to treat MS. When I checked again with the pharmacy in May I was told that because of an FDA quarantine it wouldn’t be available until July. This sounded like more FDA monkey business to me and I was receiving many desperate calls from patients. I saw Dr. Hoffer about it and he suggested having a compounding pharmacy make it up here in Victoria. He called a pharmacist and was told it could be done. A 100mg per ml, 30 ml bottle would cost $30. Patients require 2 bottles per month costing $60. We were paying $8 per bottle for $16 a month for imported thiamin. More than 3 times as expensive locally, but at least the spectre of a wheelchair hanging over us has been lifted for now.

In summary, there is a roadblock at the neurologists’ door for MS victims, but there is a ray of hope. In the 20 plus years I have been working to get the word out of a successful treatment for MS, I have talked with many GPs and the majority of them have told me that they saw no harm in helping these patients with the treatment even though they felt it wouldn’t work. With the increasing acceptance of alternative therapies by many physicians and the demand by an informed public for therapies which transcend the “cut, burn and poison” routine of orthodox medicine, an exciting new era is dawning for many people stricken with diseases which were formerly considered to be untreatable.


Dale Humpherys
103-9905-5th St
Sidney; BC Canada
V8L 2X6

August 7, 2006 Posted by | Health | , , , , | Leave a comment

Entry for July 23, 2006

Today I looked up Wernicke’s Encephalopathy in more detail and I don’t think I have the symptoms to match. Hopefully going to a Neurologist will help. Here’s what it says:

Wernicke’s Encephalopathy

Background: Wernicke encephalopathy is a serious disorder caused by thiamine deficiency. Dr. Carl Wernicke, a Polish neurologist, described it in 1881 as a triad of acute mental confusion, ataxia, and ophthalmoplegia. Korsakoff amnestic syndrome is a late neuropsychiatric manifestation of Wernicke encephalopathy with memory loss and confabulation; hence, the condition is usually known as Wernicke-Korsakoff syndrome or psychosis. It is most often seen in alcoholics, but it can be seen in disorders associated with malnutrition and also in chronic hemodialysis patients, and in patients with AIDS. Although not frequently diagnosed, the disease is more frequent than commonly supposed.

Pathophysiology: Many factors interact to reduce intracellular thiamine in brain cells. As the thiamine (vitamin B-1) deficiency develops, enzymes and systems dependent on thiamine begin to function less well, leading eventually to cell death.

Thiamine deficiency affects the thiamine-dependent enzyme transketolase involved in the pentose phosphate pathway leading to problems in the maintenance of the myelin sheaths in the nervous system, metabolism of lipids and glucose, and production of branched chain amino acids.

Thiamine deficiency also reduces the conversion of pyruvate to acetyl coenzyme A, which results in less efficient oxidative phosphorylation and increased lactic acid production. In addition, thiamine is also a cofactor for the conversion of alpha ketoglutarate to succinate, which is important in GABA metabolism and the electrical stimulation of neurons.

Thiamine deficiencies are often associated with other B vitamin deficiencies. Vitamin B deficiencies affect the efficacy of the citric acid cycle and result in cellular energy deficits.

This disease, due to a nutritional deficiency of thiamine, can be fatal if not treated. Typically the oculomotor findings are weakness of abduction (usually bilateral but not symmetrical), gaze evoked nystagmus, internuclear opthalmoplegia, vertical nystagmus in the primary position, and a decreased VOR. In monkeys and humans, lesions have been found cranial nerve nuclei III, IV, VI and VIII, as well as the thalamus, hypothalamus, periaquiductal gray, cerebellar vermis and the dorsal nucleus of the vagus.

I don’t think I have Wernicke encephalopathy as I don’t have a Thiamine deficiency. Because there are no diseases associated with a riboflavin deficiency, I don’t think I have anything more serious than a simple vitamin deficiency. That’s probably why the doctors can’t find anything wrong.

In a way, I was very lucky to have a B2 deficiency. It could’ve been a lot worse…

July 23, 2006 Posted by | Health | , | Leave a comment

Entry for July 22, 2006

With no luck at the pharmacies or the health food stores my wife suggested that I try the Naturopath. I send her an email to see if she can order it. It is after all, a natural supplement. Here is my email:

I visited my regular doctor yesterday and we suspect that I have a Riboflavin deficiency. My Thiamine blood test came out normal so I suggested that I need Benfotamine (fat soluble B1) to help the neurological effects caused by the B2 deficiency. He is now going to refer me to a Neurologist but I suggested a pharmaceutical supplement called Riboflavin (Tetra) Butyrate for better absorption. I’ve tried several pharmacies and health food stores with no luck. I did manage to find a lab near Montreal called Kabs that have it.

Is it possible for you to order this for me?

One of the things I’ve noticed about these vitamin/mineral deficiencies is that there doesn’t seem to be any consistency. One site says one list of symptoms and another says something else. I’ve come across Riboflavin deficiency before but I discounted it and despite no improvement taking 300 mg a day, it lead me to believe it was something else.

July 22, 2006 Posted by | Health | , , , | Leave a comment

Entry for July 21, 2006

It’s an hour before my doctor’s appointment and I use google one last time to see if I can find anything. Because of the positive effect of Benfotamine, I’m convinced that that I have something reducing the nerve sheaths in my head.

And with one quick search I come across the answer:

Effects of riboflavin deficiency on nerve fibers

Ultrastructural studies indicate that riboflavin deficiency induced by either dietary restrictions alone or with the addition of the antagonist galactoflavin severely affects the structural integrity of myelin lamellae. The degenerative process induced by riboflavin deficiency is time dependent. Nonmyelinated nerve fibers are not affected ultrastructurally by the deficiency. Cellular organelles of both myelinated and nonmyelinated nerve fibers remain intact and presumably functional.

Now it’s making a lot of sense. The B2 deficiency is causing the reduction of the myelin nerve sheaths and I need the extra B1 to build it up again. HOLY COW! Wait until I present this to my doctor!! I can’t believe it!!

I must admit I was a litle nervous about seeing my regular doctor. With the new research I found this morning, I’ll go the angle of a vitamin B2 deficiency, explain about Benfotamine and see if he can prescribe the fat soluble version called Riboflavin Tetrabutyrate.

Form in Dietary Supplements

What forms of vitamin B2 are found in dietary supplements?

Riboflavin is found in its simplest chemical form in most dietary supplements. However, when active in the body’s metabolic pathways, this vitamin usually takes the form of flavinadenine dinucleotide (FAD) or flavin mononucleotide (FMN). Both of these forms of vitamin B2 are water-soluble. One fat-soluble version of the vitamin, called riboflavin tetrabutyrate, has also been the subject of experimentation in treatment of riboflavin-related disorders, but is not widely available as a dietary supplement.

Nutrient Interactions

How do other nutrients interact with vitamin B2?
Vitamin B2 status is strongly affected by intake of vitamin B1. Adequate supplies of vitamin B1 can help increase levels of vitamin B2. However, very high levels of vitamin B1 intake can increase the loss of vitamin B2 in the urine. Other nutrients, especially iron, zinc, folate, vitamin B3 and vitamin B12 are not fully available in the body without adequate supplies of riboflavin.

Riboflavin assists in turning fats, sugars, and protein into energy. Riboflavin is needed to repair and maintain healthy skin. Riboflavin also assists in regulating bodily acidity. There are no diseases associated with a riboflavin deficiency. However, riboflavin deficiencies commonly accompany other vitamin deficiencies.

I’ve noticed for a while now that my itchy eyes are getting worse. I have to use eye drops at least five and six times a day. They have always been itchy and red but never like this. The vitamin A made a huge difference so why are my eyes so itchy? I think it’s linked to the high doses of Benfotamine and how it can actually cause an increase loss of B2 in the urine. I’ll cut down using the Benfotamine and see if that makes a difference.

Last weekend I picked up some vegetables for trying in my new juicer. It was a bit of work to get a little bit of juice but I enjoyed it. I made veggie juice from 1 cubumber, 1 beet, 2 stocks of celery and a bunch of baby carrots. Really nice sweet taste and it was better than I thought it would be.

July 21, 2006 Posted by | Health | , , , , | Leave a comment

Entry for July 20, 2006

A number of people at work knew I was waiting for the test results and to my embarrassment, I tell them it’s normal. Boy do I look stupid… So it’s back to Doctor Google.

I’m starting to wonder if there is any condition that can cause the body to require an increase of Thiamine. A quick search doesn’t really turn up anything.

What am I going to tell the doctor tomorrow?

July 21, 2006 Posted by | Health | | Leave a comment

Entry for July 20, 2006

I get a call from the doctor in the walk in clinic and the test results are in..FINALLY! The doctor has reviewed them and the results? NORMAL

What? I asked if she had all four results and she agreed that all four were now complete. Normal? How is this possible? I ask her to fax the results to my doctor since I am seeing him tomorrow.

No Beriberi. So why does Benfotamine have such an effect on my neurological symptoms?

I’ve checked the dosage to what the iridologist recommended. She divided my vitamins into two higher doses instead of three spread out during the day. And since I’ve been taking these divided doses, for the past two days I’ve had a weird mild chest pain around lunchtime. I haven’t bothered to replenish my niacin so could this be the problem?

I decide to take my night Benfotamine at lunch and the mysterious pain disappears almost instantly. What can I do now? If my Thiamine levels are okay why has the head pinching stopped never to return since I started Benfotamine? I’m starting to wonder if I’ll ever get an answer.

I’ll mention Riboflavin and Magnesium to my doctor tomorrow and let’s see where that leads… If that fails, I’ll ask for the referral to the Environmental Health Clinic to see Riina Bray.

How is it possible that a person who isn’t deficient in Thiamine need a Thiamine supplement???

July 20, 2006 Posted by | Health | , , , , , | 2 Comments

Entry for July 13, 2006

Nineteen days and still no test results so I call the lab again.

I give them my health card number and we go through the routine. She says they were completed on June 18th. I explain that I’ve spoken to my doctor who has only received one test out of four. She asks me to clarify the test results. I give her the three tests and I explain that it’s the Thiamine test that I am waiting for. She looks it up in her computer and says it will take 15 days so I politely inform her that today makes it 19 days.

She now tells me that for a Thiamine test, they ship it to their lab in London as the test is not done at the Toronto location and that is why it takes 15 days. She adds that it’s possible it’s taking longer because of the long weekend.

So I’ll give them one day credit for the long weekend.

Eighteen days and still no test results…

July 13, 2006 Posted by | Health | , | Leave a comment

Entry for July 11, 2006

Out of curiosity, I email the lab to find out how long it takes for a Thiamine test. I wanted to see if I got the same answer. Here is the response:

Thiamine is done at a GDML location. Turn Around Time is approx 15 working days. Specimen must be separated and frozen 30 minutes after collection.  Please call the Billing Dept for the cost.

So I’m guessing that 15 working days takes me until July 7th (Last Friday) Today is Tuesday so it should be anyday now.

July 11, 2006 Posted by | Health | , | Leave a comment

Entry for July 11, 2006

Now that I’ve established that the lab has completed the test results, I give the doctor’s office until noon to call me. There is no call so I contact them. I speak to the secretary and she searches the computer and says they are still waiting for the test results. I explain that I contacted the lab and they told me it was completed. She checks again and puts the phone down. She comes back after a few minutes and explains that they do not have the results. So it’s back to the lab. They have the B12 result but are still waiting for Folate, CRP and Thiamine. She says that if there is anything abnormal about the results, the lab will call them directly.

I call the lab again and explain that I’m looking for my test results. She looks it up in the computer and tells me they have been completed. I explain that I just got off the phone from the doctor’s office and they have not yet received the results. She asks me to name the type of tests that are still outstanding: Folate, CRP and Thiamine. She explains that the results have been sent twice to my doctor and that the Thiamine test takes 15 days and it’s not completed yet. The doctor’s office only has one of the test results so I ask her to fax the results again.

What a joke. No patient should have to go through this.

July 11, 2006 Posted by | Health | , | Leave a comment

Entry for July 06, 2006

Followed up with the doctor who did the test results for Beriberi. The secretary gave me a hard time saying that if I didn’t hear from them then the test result was normal. There is no way that it came back normal so it’s my guess that it’s not back yet.

I explained that it has been over two weeks and if it was fine, then I wanted to know. I think they should call everyone regarding the test results whether they are fine or not.

After a brief pause, she comes back on the phone and says they are still waiting for the Thiamine test.

Almost three weeks and still no results…

July 6, 2006 Posted by | Health | , , , | Leave a comment

Entry for July 03, 2006

A while back I made the discovery about the link between B1 and the myelin sheaths that protect the nerves. Today, I discover what the myelin sheaths are made out of. Sounds exactly like the feelings on the top of my head…

Nervous System Support

Vitamin B1 also plays a key role in support of the nervous system, where it permits healthy development of the fat-like coverings which surround most nerves (called myelin sheaths). In the absence of vitamin B1, these coverings can degenerate or become damaged. Pain, prickly sensations, and nerve deadening are nerve-related symptoms that can result from vitamin B1 deficiency.

Approximately 30% of your brain is composed of lecithin. Of the insulating and protective sheaths that surround your brain, spine, and thousands of miles of nerves, lecithin accounts for two-thirds of their composition; and of all the muscles in your body, your heart – the hardest muscle to fatigue – has the highest lecithin content.

Prickly sensations? I’ll add lecithin to my daily vitamins…

July 3, 2006 Posted by | Health | , , , , , | Leave a comment

Entry for June 25, 2006

Tonight I’m googling away to find any reported cases in Canada of Beriberi. I come across a case report from Toronto’s Mount Sinai journal of medicine. Now I don’t have Wernicke’s encephalopathy but it’s an interesting read because he was a non-alcoholic. The other interesting fact is that it’s mentioned that a Thiamine deficiency can be caused by a Magnesium deficiency. (Better look up those symptoms…)


Wernicke’s Encephalopathy in a Non-alcoholic Man

Wernicke’s encephalopathy, a serious neurological disorder caused by thiamine deficiency, is mostcommonly found in chronic alcoholics. We present a typical case of Wernicke’s encephalopathy in a non-alcoholic man. Our patient presented with altered mental status, slurred speech, fever, vomitingand headache of one-week duration. An infectious etiology of the symptoms was ruled out by spinal fluid cultures. The patient improved dramatically within 24 hours of administration of thiamine.


WERNICKE’S ENCEPHALOPATHY (WE) is a serious neurological disorder caused by thiamine deficiency and is most commonly found in chronic alcoholics. Typically, patients have the “classic triad” of symptoms: oculomotor abnormalities, gait disturbance and global confusional state. However, some patients may not exhibit this triad. The diagnosis is then based on clinical suspicion and rapid reversibility of symptoms after administration of thiamine, or autopsy demonstration of the characteristic lesion. We report a case of Wernicke’s encephalopathy in a non-alcoholic man.

Case Presentation

A 34-year-old African-American man presented with altered mental state, fever, slurring of speech, vomiting and headache of one-week duration. The patient denied alcohol or drug abuse, protracted vomiting, starvation, hospitalizations or abdominal surgery and indicated that he ate a normal diet. He also denied any history of sexually transmitted diseases or promiscuity. He had had occasional headaches, but had never been seen by a doctor for this complaint. He claimed to be well otherwise. On examination, the patient was alert, but disoriented. His temperature was 102°F; his pulse and blood pressure were normal. He had bilateral ophthalmoplegia with vertical nystagmus, weakness of both lower extremities and gait ataxia. There was no neck rigidity or tenderness. No other focal neurological deficit was present. Complete blood count and serum electrolytes, including magnesium, were within normal limits.
The liver function tests showed normal enzymes and serum bilirubin levels with a low normal albumin.

In view of the normal hemoglobin level (14.9 g/dL), serum folate was not done. Urine toxicology was negative. Although the patient declined to have an HIV test, he had normal CD4 counts with a normal CD4/CD8 ratio. Computerized tomography (CT) scan and magnetic resonance imaging (MRI) of the brain were normal. The patient was admitted to the intensive care unit with the differential diagnoses of meningitis, cerebrovascular event or Wernicke’s encephalopathy. He was empirically given cephtriaxone, vancomycin, and acyclovir because of fever, vomiting, altered mental state and lower extremity weakness, which suggested the possibility of meningitis or encephalitis. Cerebrospinal tap results were normal and all antibiotics were stopped immediately after the spinal fluid cultures were reported as negative. He was also given 100 mg of thiamine intravenously and started on oral thiamine supplementation of 100 mg daily. Within 24 hours the patient improved dramatically. He became alert and fully oriented. The ophthalmoplegia and vertical nystagmus resolved and the leg weakness improved markedly, with some residual ataxia. The patient was discharged home with continued outpatient physiotherapy.


Wernicke’s encephalopathy is a common but preventable disorder due to thiamine deficiency. Alcoholics account for most cases, but thiamine deficiency may infrequently occur in patients with hyperemesis, starvation, hemodialysis,� cancer, acquired immune deficiency syndrome (AIDS), magnesium depletion, gastroplasty/gastric bypass surgery, rapid weight loss, anorexia nervosa, refeeding syndrome and prolonged intravenous feeding. Body stores of thiamine are only sufficient for up to 18 days. Thus, depletion can occur rapidly with restricted intake or prolonged vomiting.

The Canadian recommendation for thiamine intake is 1.1 mg per day, whereas the American recommendation is 1.4 mg per day. Thiamine is a co-factor of several enzymes, including transketolase and pyruvate dehydrogenase. Activity of the latter enzyme, a rate-limiting tricarboxylic acid cycle enzyme, is significantly reduced in autopsied brain tissue of Wernicke’s encephalopathy patients and from rats treated with a central thiamine antagonist, pyrimethamine. In animal studies, evidence suggests that such enzyme deficits result in focal lactic acidosis, cerebral energy impairment and depolarization of neurons resulting from increased glutamate in vulnerable brain structures. This depolarization may result in n-methyl-d-aspartate receptor-mediated excitotoxicity as well as increased expression of immediate early genes such as c-fos and c-jun, resulting in apoptotic cell death. Another mechanism may involve free radicals and alterations of the blood-brain barrier. Anatomical abnormalities in WE occur mainly in periventricular regions of the diencephalon, midbrain, brainstem and superior vermis of the cerebellum. In acute cases of WE, the lesions consist of symmetrical discoloration with petechial hemorrhages. Amnesia is related to lesions of the medial dorsal nuclei of the thalamus. Shrinkage of the mamillary bodies can also be seen.

Symptoms and signs indicative of WE usually include vomiting, nystagmus (horizontal more than vertical), medial and lateral rectus muscle palsies leading to unilateral or bilateral ophthalmoplegia, fever, ataxia and progressive mental deterioration that evolves to a global confusional state, coma, and death. Other manifestations of a nutritional deficiency, such as polyneuropathy, may also occur. Tachycardia and orthostasis may be related to an impaired autonomic nervous system or coexistent cardiovascular beriberi. The true prevalence of WE at autopsy is about 3%, much higher than what is diagnosed clinically in the general population. Acute WE should be suspected in all alcoholics with neurological symptoms, especially those with evidence of calorie or protein malnutrition and peripheral neuropathy. The classic triad of oculomotor abnormalities, gait disturbance and global confusional state occurs only in one-third of the patients. The diagnosis of WE is based on the clinical suspicion and rapid reversal of symptoms after the administration of thiamine. Decreased serum activity of erythrocyte transketolase and MRI (sensitivity 53% and specificity 93%) may be helpful in confirming the clinical diagnosis. Typically, there is an increased T2 signal of the paraventricular region of the thalamus and peri-aqueductal regions of the midbrain. There can also be enhanced T1 weighted spin-echo (SE) sequences after intravenous gadolinium administration in the acute phase of WE. Normal MRI does not exclude the diagnosis of WE. On the other hand, the sensitivity of the CT scan in detecting the characteristic lesion of WE is extremely low (13%), so it is not useful in the diagnosis of this entity. WE is a medical emergency and requires the immediate administration of thiamine in a dose of 50 – 100 mg, either intravenously or intramuscularly. Doses should be given daily, to build up the body reserves until the patient is able to resume a normal diet. The central nervous system is almost entirely dependent on glucose for its energy requirements. Thiamine is an important co-factor needed in several steps of glucose utilization. Therefore, loading of glucose in a thiamine-deficient person can�precipitate a neurological crisis (WE) or can cause rapid worsening of mild symptoms. To avoid this complication, thiamine should always be given prior to any intravenous glucose administration whenever this diagnosis is suspected. Patients who recover show improvement of oculomotor palsies within hours of thiamine administration. Ataxia improves more slowly. About one-half the patients recover incompletely and are left with a slow, shuffling wide-based gait and inability to take one step in quick succession after the other. Apathy, drowsiness and confusion diminish gradually. As these symptoms recede, an amnesic state with impairment in recent memory and learning may become more apparent in some cases (Korsakoff’s psychosis).


WE is uncommon in non-alcoholics, but not rare. One should have a high index of suspicion in patients with hyperemesis, starvation, dialysis, cancer, magnesium depletion, AIDS, gastroplasty/ gastric bypass surgery, rapid weight loss, anorexia nervosa, refeeding syndrome or prolonged intravenous feeding. Our patient had none of the aforementioned conditions. The recommended treatment is the administration of thiamine, and most patients respond within 24 – 36 hours.

June 25, 2006 Posted by | Health | , , , | Leave a comment

Entry for June 25, 2006

Woke up this morning and I still have the vibration in fact, it was quite stong. I know that the vibration could be from the three different B vitamins (B1, B2 and B3) So I’ll add B2 and B3 to my vitamin schedule today and see if it makes a difference. I wonder if I can find any fat soluble B2, B3 vitamins?

June 25, 2006 Posted by | Health | , , , | Leave a comment

Entry for June 21, 2006


Back to researching B vitamins. You’d think with everything that I have read so far, I’d be an expert. Then Doctor Google comes up with this gem. Ok, I don’t have HIV or AIDS, but the article talks about B vitamin deficiencies and how Thiamine is used in treating diabetic neuropathy.


Stanley Mirski, M.D., has reported that a large percentage of his diabetic patients who suffer from neuropathy have achieved improvements with daily thiamine supplementation in doses of 50-100 mg. Using a fat-soluble form of thiamine such as thiamine tetrahydro-furfuryl disulfide may be preferable because of the relatively poor absorption of water-soluble forms of this vitamin. This type is contained in Cardiovascular Research’s Allithiamine. A large number of HIV-positive people have reported to me their successful elimination of neuropathy with the combined use of the B vitamins discussed here. The information on acetyl-l- carnitine is too recent for much in the way of anecdotal reports to have surfaced, but it might be an important addition to improve the chances for successful elimination of neuropathy. Research has made it clear that people living with HIV are often deficient in carnitine.

WHAT!!!! There is a fat-soluble form of thiamine???!!!! I pull up the web site for the local health food store down the street and I type “thiamine tetrahydro-furfuryl disulfide” into the search engine and nothing comes up. So I search “thiamine” alone and get two results. I click on the second result because it says B1 and it’s the suppliment I already have. I click on the second one and it’s called Benfotiamine. I’ve never heard of it and they provide a link to the manufacturer’s web site. I click on that and I read about how it raises the level of thiamine in the blood. NOW THAT’S WHAT I NEED!!! And it was about three blocks away from my house the entire time.

Benfotiamine for Neuropathy, Retinopathy, and Vitamin B1 deficiency

Recent studies have shown strong evidence pointing to benfotiamine preventing and helping diabetic neuropathy and retinopathy.. The original patent on benfotiamine gave information that it is even less toxic than common vitamin B1 (thiamine hydrochloride usually).. To date, there has been no reports of any known, negative interactions with any medications.. Any condition that is the result of a thiamine deficiency will respond quite well to benfotiamine.


Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.

Thiamine and its Co-enzyme, TPP

Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name “thiamine diphosphate.” In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as “active acetate.” Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called “oxidative decarboxylation” and for this reason, TPP was originally referred to as “cocarboxylase.” TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical “super-thiamin” it does this through several different cellular mechanisms, as discussed below.

Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.

Found another web site that talks about the treatment using this suppliment.


Though the body cannot use more than about 10mg of common, water-soluble vitamin B-1 per day, benfotiamine is lipid-soluble and can safely be used at much higher levels than common vitamin B-1.

Most people get excellent results in 14-21 days time using two 150mg. Capsules twice per day (two in the morning and two in the evening). Benfotiamine need not be taken with meals. Some people get better results increasing the dosage to 900mg or 1200mg per day after the first two weeks. The point here is that benfotiamine is safe at any reasonable daily usage level. An individual should merely find the level that produces the maximum beneficial effect without reaching a point of diminishing return beyond which the excess amount is wasted.

Some case studies have documented daily usage in the 600mgday range and more with interesting anecdotal and clinical results: Holladay Case Studies.

Also, Dr. Brownlee participated in a clinical trial using 600mg/day: Clinical Trial Using 600mg with dramatic results after increasing daily usage to 600mg. The neuropathy symptoms ceased progression and began to reverse and people experienced a complete cessation of sciatica episodes. Also, the average blood pressure dropped from a persistent 145/90 to 120/80, without the use of other blood pressure medications.

Most people get excellent results in 14-21 days using two 150mg???!!!! How do I get a hold of this stuff?

I’m really disapointed that the naturopath didn’t mention this. I’ve been taking B Complex for so long now with very little results, you’d think she could’ve at least mentioned that there are fat soluble vitamins. She seemed more interested in talking about me in her class.

I don’t really think she did enough reading or understanding of my symptoms. It’s really hard to knock what she was doing because she gave me two suppliments that have helped me tremendously but there comes a point where you say: “This is not working.” The acupuncture doctor did that and I’ll give her the most credit for helping me figure out my symptoms and leading me on my current path to understanding the root cause even though it had nothing to do with acupuncture.

I’d love to go back to her one day not for a treatment, but to tell her all about my discoveries since I stopped the acupuncture. I’d love to see her do the cupping with no pepperoni marks and watch as my blood pressure reads normal. That would be great and maybe someday I’ll see her for another appointment. Imagine if the results came back  and I could tell her that I have Beriberi? She won’t believe it and neither will anybody else.

June 21, 2006 Posted by | Health | , , , | Leave a comment

Entry for June 20, 2006

I’ve been taking higher doses of B complex and there doesn’t seem to be any improvement. In fact, in some cases it’s making me feel worse. I have a theory. If B vitamins are water soluble, then why don’t I find some kind of snack food that I could eat all day long and keep the level of B1 in my body for better absorption. So I do a quick search and discover peanuts are high in thiamine. Then I discover that Veggie Burgers are high in B vitamins because they are made from Soy. I remember from the diet diary that the veggie burger I had from Licks made me feel great and now I know why.

So I went down to Shoppers to look for some snack food and pick up some peanuts and almonds.

Tomorrow I’ll try another test. Because the higher doses don’t appear to be working better, I take my multivitamin in multiple doses throughout the day. The dosage for B1 is only 10 mg but maybe this will improve my absorption. I check the dosage for the fat soluble vitamins to make sure I’m under the toxic limit and it’s actually quite low. I won’t take any Niacin (B3) either just to see if it makes a difference.

June 20, 2006 Posted by | Health | , , , , | Leave a comment

Entry for June 18, 2006

Woke up today and took my new daily dosage of vitamins and about half an hour later I feel that weird kind of feeling in my head. I had the same feeling yesterday and I figure it’s the shock of the vitamins working.

Around one o’clock I don’t feel so good. For the last few hours I have a weird mild pinching in my chest. It’s the same feeling I had the very first time taking B complex vitamins. I lie down on the couch to have a rest and I notice that I’m vibrating. How is this possible when I only took my vitamins a few hours ago? I have a theory…

Because most B vitamins vitamins are water-soluble, the body can only absorb so much while it’s present in the body. Doctor Google?

Water-soluble vitamins

  • B-complex vitamins and vitamin C are water-soluble vitamins that are not stored in the body and must be replaced each day.
  • Use of megadoses of vitamins is not recommended.
  • These vitamins are easily destroyed or washed out during food storage and preparation.
  • The B-complex group is found in a variety of foods: cereal grains, meat, poultry, eggs, fish, milk, legumes and fresh vegetables.
  • Citrus fruits are good sources of vitamin C.Vitamins are essential nutrients found in foods. The requirements are small but they perform specific and vital functions essential for maintaining health.

    The two types of vitamins are classified by the materials in which they will dissolve. Fat-soluble vitamins — vitamins A, D, E and K — dissolve in fat before they are absorbed in the blood stream to carry out their functions. Excesses of these vitamins are stored in the liver. Because they are stored, they are not needed every day in the diet.

    By contrast, water-soluble vitamins dissolve in water and are not stored; they are eliminated in urine. We need a continuous supply of them in our diets. The water-soluble vitamins are the B-complex group and vitamin C.

    Water-soluble vitamins are easily destroyed or washed out during food storage or preparation. Proper storage and preparation of food can minimize vitamin loss. To reduce vitamin loss, refrigerate fresh produce, keep milk and grains away from strong light, and use the cooking water from vegetables to prepare soups.

    Vitamin B-Complex

    Eight of the water-soluble vitamins are known as the B-complex group: thiamin (vitamin B1), riboflavin (vitamin B2), niacin, vitamin B6, folate, vitamin B12, biotin and pantothenic acid. These vitamins are widely distributed in foods. Their influence is felt in many parts of the body. They function as coenzymes that help the body obtain energy from food. They also are important for normal appetite, good vision, healthy skin, healthy nervous system and red blood cell formation.

    Beriberi, pellagra and pernicious anemia are three well-known B-vitamin deficiencies. These diseases are not a problem in the United States, but occasionally they occur when people omit certain foods or overeat certain foods at the expense of others. Alcoholics are especially prone to thiamin deficiency because alcohol replaces food.

    When grains and grain products are refined, essential nutrients lost during processing are put back into these foods through a process called enrichment. Among the nutrients added during the enrichment process are thiamin, niacin, riboflavin, folate and iron. Some examples of enriched grain products are white rice, many breakfast cereals, white flour, breads, and pasta.

  • Another web site suggested taking 100 mg of thiamine three times a day to help any kind of deficiency because it is water soluble. I’m willing to bet the fact that I’ve been drinking 2 litres of water a day is minimizing the effect of the B vitamin absorbtion. I’ll try to cut down on my water intake for the week and see what happens.

    June 18, 2006 Posted by | Health | , , , | Leave a comment

    Entry for June 17, 2006


    Woke up early and my left arm had pins and needles. It had a totally weak feeling to the entire arm. Maybe I was sleeping on it. Nothing unusual I guess. Everybody gets pins and needles.Went to the lab for 8:00 AM.

    I arrive at the lab and as I looked at the requistion form, I realize that I didn’t ask the doctor to check my triglycerides. I wanted to see if the pharmacutical doses of niacin had any effect to lower them. I had a pen with me so I figure I’ll just check it off. The only problem was that the doctor used blue ink and I only had black. Maybe the nurse won’t notice…

    I take my number and sat down for a while. They call my number and I provide them with the form. Almost right away the nurse asks me if I checked the box for triglycerides. I admit that I did and I get scolded for doing so. “Only the doctor can select the boxes for testing. I explain that I didn’t want to go back to the doctor to have him select the extra box but I appologize.

    It was a stupid thing for me to do but I figured because they were doing the test anyway…it would be no big deal. After going back to my seat, she calls me back up to the desk. This time I was worried that the test would be voided because of my tampering. Nope, she explains that a thiamine test is not covered by the Ontario Government and that it will cost me $50.00. Expensive, but it could be worth every penny.

    So that’s why it’s not a routine test…

    June 17, 2006 Posted by | Health | , , , | Leave a comment

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