Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for March 06, 2008

The past couple of days I’ve had itchy watering eyes. Today I tried taking some Sam-e and that seemed to help. I stopped taking it a while back because as usual, I moved on to something else.

August 22, 2009 Posted by | Health | , | Leave a comment

Entry for February 10, 2008

Walking about the supermarket today and out of nowhere I felt a sharp chest pinch. I’m not sure of the exact cause but it’s the similar pain I’ve had in the past. I’ve added SAM-e in the past week so I wonder if that has anything do with it?

August 20, 2009 Posted by | Health | , | Leave a comment

Entry for February 03, 2008

I’m really happy about getting results with SAM-e and the other thing I’ve noticed? The vibration has stopped since I started taking it. So is it because I found the root cause or is it because it has a calming effect on the body?

August 19, 2009 Posted by | Health | , , | Leave a comment

Entry for February 02, 2008

SAMe Is Essential For Brain Function

SAM-e (S-Adenosylmethionine) is an amino acid derivative that has been clinically proven.  Found in all living cells, SAM-e is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. The body makes SAM-e from the amino acid methionine and the cofactor vitamins B6, B12 and folic acid.

SAMe is the primary methyl donor available in the brain. Some of the biochemicals essential for proper nervous system function that benefit from SAMe include epinephrine, norepinephrine, serotonin and dopamine. Transmethylation in the brain includes actions upon the phospholipids that are the primary components of all cell membranes.

Supplementation with SAMe improves the body’s ability to manufacture phospholipids for use in the brain and helps keep neurotransmitters in balance.

Animal studies show that SAM-e increases levels of serotonin, but not the same way as SSRI or tricyclics work. They prolong the effect of a neurotransmitter by blocking its reuptake after it ferries a signal across the gap from one nerve cell to the next.

SAM-e, by contrast, appears to actually build neurotransmitters by donating part of its own chemical makeup, a methyl group. A common currency in metabolic processes, methylation also feeds the fats that stabilize nerve cell membranes and the receptors on them, making brain cells more responsive to a broad array of operations.

 I love this article for the comparison between Sam-e and Paxil (SSRI drug). I wonder if the neurologist knew this? Probably not. Who am I kidding?

After my discovery a few months back with the active form of B vitamins for better absorption, I’m always interested in supplements with higher absorption rates and SAM-e is no exception. A few days after taking SAM-e and there is a definate WOW factor. Once again, overnight my eyes feel stonger and my skin is so smooth and fantastic!

I think it’s safe to say the amino acid test is very accurate with a low level of methionine. Now if I can only find the other ones…

August 19, 2009 Posted by | Health | , , | Leave a comment

Entry for January 31, 2008

So now I discover a link between SAM-e and melatonin.

SAM-e Is Necessary for Melatonin

One of the most exciting things about SAMe is that it is melatonin’s daytime equivalent. The natural synthesis of melatonin during the night is dependent on the synthesis of SAMe during the day. SAMe is necessary for the biochemical reaction that converts serotonin into melatonin. (Serotonin is the neurotransmitter that drugs like Prozac elevate). SAMe and melatonin are entwined in a circadian rhythm that see-saws back and forth as the sun rises and sets. SAMe is melatonin’s other half: when melatonin levels shoot up at night, SAMe stays low. But during the day, when melatonin falls, SAMe levels climb. Without adequate SAMe during the day, neither melatonin nor serotonin can be synthesized. And both are dependent on light and dark.

One of the most fascinating animal studies on SAMe and melatonin was published in the Journal of Neurochemistry in 1995. Researchers demonstrated in great detail the perfect orchestration that occurs between levels of SAMe and melatonin. The so-called “nyctohemeral” rhythm (pertaining to both day and night) was documented almost minute-by-minute. Data were translated onto graphs showing the see-saw relationship between melatonin and SAMe (Fig. 1).

Both melatonin and SAMe are controlled by an internal “clock” that knows lightness from darkness. In the evening, about 30 minutes before sunset, levels of SAMe shoot up to their highest level. They stay there for about an hour, and then suddenly drop. When this happens, melatonin kicks in. Melatonin increases for four hours, while SAMe drops. Five hours into the night, melatonin hits its high, and SAMe hits its low. Melatonin stays elevated until three hours before sunrise, when it abruptly falls. Meanwhile, SAMe builds up. Five hours into the day (around 11:00 A.M.), SAMe reaches its peak level again, then begins a gradual descent until evening.

Serotonin levels follow roughly the same pattern-higher during the day and lower at night. It appears that the serotonin synthesized during the day is used at night to make melatonin. SAMe is absolutely crucial for the natural synthesis of melatonin because it donates a methyl group molecule to the enzyme that converts the acetylated form of serotonin to melatonin.

Melatonin is not traditionally though of as a hormone that effects mood, but it does. When melatonin levels are low, you tend to wake in the wee hours in a panicked state, even if things may be generally okay in your life. You will wake fearing the worst about the least important things or feeling depressed for no real reason. Melatonin is made from the amino acid tryptophan, which also makes serotonin. It’s production in the brain requires methionine and SAMe.

What a fantastic article. Off to the health food store looking for SAM-e!

August 17, 2009 Posted by | Health | , , , | Leave a comment

Entry for January 31, 2008

I’ve been doing a lot of reading about lecithin and methionine lately and I came aross something called s-adenosyl methionine with a link to the adrenals and how it can be effected by methionine and riboflavin deficiencies. This sounds all too familiar…

Methionine is also used by the body to manufacture SAMe, also known as S-adenosyl-methionine or S-adenosyl-L-methionine. SAMe is found in every cell in the body. SAMe has been shown to be effective as a treatment for osteoarthritis and associated joint pain, stiffness, and inflammation.

It is important to note that dietary supplements of methionine do not appear to elevate SAM-e levels or have the same effect on mood states found with SAM-e. Doses of 200-600 mg per day may be effective in elevating mood and treating mild depression.

Highest concentration of SAM in body (in order):
1) Adrenal gland
2) Pineal gland

“Deficiencies of any of the active coenzyme forms of vitamins B2, B6, B12 and folic acid will disrupt SAMe production, and conversely diminished SAMe production will impair conversion of folic acid and B12 to their coenzyme forms.

August 17, 2009 Posted by | Health | , , , | Leave a comment

   

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