Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for March 07, 2007

I don’t feel the lower dosages of zinc are doing anything. I had the greatest success with around 80 mg of zinc a day without any copper. The only problem is that I think the high dosage is lowering my copper ratio and at the same time, I’m losing the magnesium.

I’d like to find a balance where I can take the most amount of zinc with the least amount of copper. I’ll need to do some more research on zinc and copper and the effect on the body.

ZINC

RDA 15 mg, recommended intake 20 to 30 mg daily; therapeutic dose up to 300 mg; best taken together with vitamin B6. Diets low in protein and high in fiber, phytates, calcium, fat and copper may decease the absorption of zinc. Increased zinc is needed with calcium or magnesium supplements, and during chronic infections, convalescence and stress.

How much zinc is too much?

The suggested upper safe limit is 50mg per day for a limited time. Too much zinc can deplete the body of iron and copper, leading to deficiencies of these minerals

Over 300 enzymes in the body need zinc to order to function properly; is needed to make important antioxidant enzymes; is essential for protein synthesis and collagen formation; governs the contractibility of muscles.

Zinc intake and absorption is needed to maintain the proper concentrations of vitamin E in the blood. Zinc levels can be decreased by diarrhea, kidney disease, cirrhosis or the liver, diabetes. Consuming “hard water” can upset zinc levels.

Inhibits Absorption: High intake of calcium, alcohol
Enhances Absorption: Phosphorus, copper, calcium, vitamin A

Functions

Zinc has a range of functions. It plays a crucial role in growth and cell division where it is required for protein and DNA synthesis, in insulin activity, in the metabolism of the ovaries and testes, and in liver function. As a component of many enzymes, zinc is involved in the metabolism of proteins, carbohydrates, lipids and energy.

Our body contains about 2-3g of zinc. There are no specific storage sites known for zinc and so a regular supply in the diet is required. Zinc is found in all parts of our body, 60% is found in muscle, 30% in bone and about 5% in our skin.

Particularly high concentrations are in the prostate gland and semen. Men need more zinc than women because male semen contains 100 times more zinc than is found in the blood. The more sexually active a man the more zinc he will require. The recommended amounts of zinc for adult men are 1/3 higher than those for women.

Researcher James Heffley, Ph.D., has determined through scientific studies that a man loses only about half a milligram (mg) of zinc in an ejaculation. This represents only about 4% of our average daily zinc intake.

Copper Toxicity: Liver cirrhosis, jaundice, symptoms of zinc deficiency.

I’m guessing that the extra copper intake was causing my jaundice and I’ve been tinkering with zinc and copper since Feb 4th. I won’t bother with the liver function blood tests. I think I was causing my own problem…

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March 8, 2007 Posted by | Health | , , , | Leave a comment

Entry for March 06, 2007

This morning I thought I would skip the fruit and have a cheese and broccoli croissant instead. All morning I start noticing the yellow colour of my hands against the other people at work. I keep it to myself but I’m starting to get really concerned about it. I can feel myself getting more stressed out and I am taking the homeopathic magnesium once every hour. I can feel the vibration and I get the occasional mild chest pain with cold hands and cold feet. The classic symptoms that I’ve had so many times before.

I look up the symptoms of a weak liver and jaundice is the only symptom I have. I’m still a little freaked out so I decide to go to a walk-in clinic after work. I’m feeling better by the late afternoon but I’m still going to see a doctor. I’d also like to see if I can get the doctor to agree to a zinc test.

The doctor’s office was full of coughing, pale looking children who looked like they had been waiting for hours. I seemed like the odd person out. After about an hour of waiting, I was called into the office. The doctor was a very young Chinese man and looked no more than 18 years old.

I start by explaining about the colour of my skin and how yellow it looks. I suggested that I may have a problem with my liver. He checks the whites of my eyes and doesn’t seem concerned. He asked me why I thought I had a problem with my liver. So I explain briefly that it may have been caused by ongoing magnesium deficiency. His response? And I quote: “A magnesium deficiency? What is that?” Okay, now I’m in deep trouble. I shouldn’t have mentioned it.

I explain that I’ve had a variety of symptoms over the past two years and I’ve discovered that they are all related to magnesium. I continue by saying I’ve recently suspected that it may be caused by a zinc deficiency and would like a blood test to confirm this.

He got defensive right away…His response: “First of all, I have never ordered a zinc blood test and this is not a standard test. You would have to pay for something like that. Secondly, I’m not even sure if the lab would be able to do a test like that and even if they could do the test and the results were abnormal, I wouldn’t even know how to treat it.”

He continues by asking me if I have a family doctor. I answer yes and I’ve clearly written his name and address on the patient form that he has in his hands. He said that if this problem has been ongoing for two years, then I should follow up with my family doctor. He continues by saying that my problem is beyond the scope of a walk in clinic.

Somewhat shocked but not really surprised, I tell him to forget the magnesium deficiency and the zinc test. Back to my yellow skin…

Again, he looks into my eyes and asks me to look down. He asks me if I have any other symptoms and offers some: Nausea, abdominal pain, dizziness, visited a foreign country and a few others. I said no to all of them and he doesn’t ask me anything about my diet.

He said he didn’t think I had anything to worry about but if I wanted a test, he would order one. Yes, I want the test…that’s what I came in for. He tells me that a copy of the results will be sent to my family doctor as well.

I take a look at his lab request form. He has checked off Creatinine, AST (SGOT), Alk. Phosphatase and Bilirubin. I have no idea what any of these things are so I look them up.

Creatinine

Endogenous creatinine is excreted by filtration through the glomerulus and by tubular secretion. Clinically, creatinine clearance is an acceptable measure of glomerular filtration rate but sometimes overestimates GFR. For each 50% reduction in GFR, serum creatinine approximately doubles.

Aspartate Aminotransferase (AST, SGOT, GOT)

U/LIntracellular enzyme involved in amino acid and carbohydrate metabolism. Present in large concentrations in liver, skeletal muscle, brain, red cells, and heart. Released into the bloodstream when tissue is damaged.

Alkaline Phosphatase

Alkaline phosphatases are found in liver, bone, intestine, placenta.

Bilirubin

Bilirubin, a product of hemoglobin metabolism, is conjugated in the liver to the mono- and diglucuronides and excreted in bile. Some conjugated bilirubin is bound to serum albumin, so-called D (delta) bilirubin. Elevated serum bilirubin occurs in liver disease, biliary obstruction, or hemolysis.

March 7, 2007 Posted by | Health | , , , , | Leave a comment

Entry for March 05, 2007

Foods that can Make the Liver Work Harder

Saturated fats are harder for the liver to process. Limit high fat meats like sausage, bacon, salami, hot dogs and high fat dairy products like whole milk, ice cream and cheese, which contain saturated fats.

Other foods to limit that have a lot of saturated fat are french fries and high fat snack foods like potato chips, Doritos and Cheese Doodles.

Limit processed foods like white bread, white rice, cakes, cookies, donuts and candy. Add whole grains like whole grain breads and cereals, brown rice, quinoa and barley to your diet.

Limit caffeine to 2-3 cups/day. Caffeine is broken down by the liver and may make it more difficult to cleanse the liver. Coffee, tea and most sodas contain a lot of caffeine.

Foods for the General Health of the Liver

Soy Beans contain lecithin which helps the liver break down fats and helps reduce high cholesterol levels; lecithin also helps maintain healthy membranes around liver cells.

Cayenne Pepper contains many phytochemicals including beta-carotene and lutein and is rich in certain B vitamins as well as vitamins C and E. It also aids in digestion.

Lemon is a bitter, acidic food which is helpful for general cleansing of the body.

Walnuts are a source of arginine which helps the liver detoxify ammonia, a waste product in the body; they are also a rich source of glutathione and omega-3 fatty acids.

Wheatgerm has arginine and essential fatty acids.

Caraway Seds contain many flavanoids and carotenoids which act as antioxidants. Caraway is helpful in liver and gallbladder disease and helps produce glutathione in the body.

General Tips for Foods that are Especially Good for the Liver

Eat plenty of fresh fruits and lightly cooked vegetables especially dark green, leafy vegetables and orange, yellow, purple, and red colored fruits and vegetables—they contain living enzymes, fiber, vitamin C, natural antibiotic substances, and anti-cancer phytonutrients.

Eat foods that are rich in glutathione or help to produce glutathione in the body. Asparagus, watermelon, broccoli and boldo are good sources of glutathione while papayas and avocados are foods that help the body to produce glutathione.

Bitter foods like dandelion greens, mustard greens, bitter melon, Romaine lettuce and broccoli raabe can help in cleansing the liver.

Herbs like dill, caraway seeds, garlic, onions, boldo, turmeric and cayenne are easy to use in cooking and can help protect the liver.

Green tea has immune-boosting properties and contains less caffeine than coffee.

Drink lots of water (6–12 cups per day) because it helps the kidneys to get rid of the toxins that the liver has broken down.

Omega-3 fats are very helpful. These fats are found in cold water fish such as salmon, tuna, mackerel, sardines and halibut. Other good sources are ground flaxseeds, flaxseed oil and walnuts.

Nuts, seeds, and avocados are good food sources of polyunsaturated fats and monounsaturated fats that are less harmful to the liver than saturated fats.

March 5, 2007 Posted by | Health | | Leave a comment

Entry for March 04, 2007

Still a little concerned about my “yellow” skin colour, I went to the health food store to see what I could find. I looked at all of the supplements that can help the liver and settled on a Milk Thistle complex that also contains Dandelion.

Milk Thistle (Silybum Marianum)

Milk thistle is believed to have protective effects on the liver and improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), and gallbladder disorders.

Milk thistle seeds contain silymarin, a powerful antioxidant that has been found effective against free-radical producing toxins in the liver. Silymarin increases the amount present of one of the liver’s most important detoxification enzymes, glutathione. Silymarin also inhibits the action of the enzyme lipoxygenase, which triggers the release of damaging leukotrienes. Finally, silymarin actually appears to stimulate protein synthesis in the liver, leading to an increase in the number of new liver cells to replace old, damaged cells. There have been more than 300 studies of silymarin. In one double-blind clinical trial, silymarin demonstrated impressive results in 129 patients suffering from various kinds of liver damage after 35 days of treatment, as compared with a control group of 56 patients. In a follow-up study lasting seven weeks, biopsies showed a remarkable return to normal cell structure, even in severely damaged livers. Other studies have supported the efficacy of silymarin in treating individuals with liver damage due to long-term exposure to toxic chemicals, alcohol-related cirrhosis, and viral hepatitis.

Dandelion (Taraxacum Officinale)

Dandelion has been used effectively for jaundice and inflammation of the liver. Like the globe artichoke, dandelion may help curtail the development of gallstones.

March 4, 2007 Posted by | Health | , , | Leave a comment

Entry for March 03, 2007

Copper And Other Mineral Imbalances As A Cause Of Allergies

Minerals play many important roles in regulating body chemistry. Not only are minerals required for glandular activity, but they serve to regulate the nervous system and every other system of the body. Toxic amounts of any nutrient will displace other vital nutrients and by doing so, result in various metabolic dysfunctions, including a wide variety of allergies.

Research reveals that copper toxicity is a major contributing cause of allergies, particularly those allergies associated with low cortisol levels. Low cortisol levels result in a chronic inflammatory process. Allergies occur because copper, in excess, deplete vitamin C, folic acid, zinc and other nutrient reserves that are required by the pituitary and adrenal glands. An excess of tissue copper also impairs liver function, resulting in a wide variety of food allergies.

Copper toxicity also results in an over-stimulation of the nervous system which leads to alterations of the pituitary-adrenal axis. Copper toxicity is often involved as a principal cause of brain, or cerebral allergies.

A copper deficiency frequently results in a lowering of tissue calcium levels, which serves to contribute to the excess histamine-type of allergies.

Many individuals suffer from a copper imbalance which is not detectable on a standard blood serum test. Copper toxicity can be identified from a hair mineral analysis, where it is indicated by either a high copper level, a high calcium level, a very low copper level, or a low sodium to potassium ratio which indicates adrenal burnout.

Many times, a food allergy problem can be traced to the relatively high copper content of certain foods. Common foods that are high in copper are wheat, corn, soybeans, chocolate and shellfish. Perhaps it is more than coincidence that these particular foods are common causes of food allergies.

Allergies And Behavior

Another class of allergies is commonly referred to as central nervous system allergies. These are reactions that detrimentally affect one’s emotions and behavior. The causes of these allergies are, in many instances, the same as those discussed above. The principal difference is that they specifically affect brain function, so that reactions are particularly noticed in one’s behavior and attitude.

Biochemical mechanisms primarily responsible for brain allergies include;

• Excessive histamine release in the brain due to an elevated copper level, or zinc deficiency.

• Alterations of vitamin, or other mineral levels in the brain due to foods, or exposure to toxic metals.

• Changes in blood sugar levels due to diet, stress, or adrenal insufficiency. The brain is extremely sensitive to both low and high blood sugar levels.

• Specific neuro-chemical effects of food additives such as Nutra-Sweet which contains phenylalanine, a neuro-active amino acid.

In the majority of cases of central nervous system allergies, we find that a copper imbalance plays a vital role. Research confirms that a copper toxicity problem causes a zinc deficiency, which in turn may result in a rise in tissue sodium levels. A high sodium level, in turn, is responsible for many of the symptoms associated with brain allergies.

Common symptoms of brain allergies in children are hyperactivity, learning disorders and concentration deficit problems. In adults, a high sodium level frequently manifests itself as manic-depressive disorders, hyperactivity, anxiety and various phobias.

Central nervous system allergies are handled the same way as other allergies. Imbalances in body chemistry need to be identified and corrected. The hypothalamus-pituitary-adrenal axis needs to be restored to normalcy. Offending foods have to be avoided for a time. Digestion also needs to be improved.

Allergies As A Symptom Of Burnout

A common hair analysis pattern noted in allergy patients is a low sodium/potassium ratio (less than 2.5:1). We call this a burnout pattern, because it is associated with adrenal exhaustion.

Allergies are a common sign of adrenal burnout. The exhausted adrenal glands simply cannot provide sufficient cortical hormones required to prevent allergic reactions.

Another common hair analysis pattern in allergy sufferers is what we refer to as an all-four-low mineral pattern. The first four minerals on the chart (calcium, magnesium, sodium and potassium) are below normal accepted values. This too, is a burnout pattern, one in which the person is under unrelenting stress, thus preventing recovery of the adrenal glands. Allergies usually accompany this particular mineral pattern.

A final hair analysis mineral pattern that is often seen when allergies are present is that both sodium and potassium levels are rock bottom, below 6 mg% for sodium and below 4 mg% for potassium. Again, this is a mineral pattern commonly associated with severe adrenal exhaustion.

Very often, in order to correct an allergy problem it is necessary to correct the underlying burnout condition. Otherwise we are just relieving symptoms and the associated allergies will never be permanently eliminated.

General Nutritional Recommendations For Allergies

Avoiding refined sugars and carbohydrates reduces allergies in a category of individuals who are classified as sugar and simple carbohydrate intolerant. Eating sugar, or simple carbohydrates in any form, places undue stress upon the adrenal glands, which are forced to respond to the sudden excess of sugar in the blood. The result is increased wear and tear on these glands, as well as on the liver and pancreas. The ingestion of sugar, especially in susceptible individuals, also upsets calcium, copper and other mineral levels, eventually causing a further alteration of body chemistry.

Refined carbohydrates lack fiber, which serves to slow the absorption of sugars into the blood stream. They also lack the essential trace elements desperately required for optimal adrenal gland support.

Eating foods appropriate for one’s oxidation type is particularly important. For the slow oxidizer, this means avoiding high-fat diets and eating adequate amounts of protein. Increasing one’s meat protein intake is often difficult for certain slow oxidizers, particularly those with a copper toxicity problem. Avoiding, or limiting dairy products is often helpful for the slow oxidizer. Dairy products are high in fat content which serves to further slow down an already slow rate of metabolism. Many slow oxidizers are also unable to tolerate milk sugar.

For the fast oxidizer, dietary fats are essential and in some cases increasing one’s intake of fats will rapidly reduce allergy symptoms related to stress-related, excessive adrenal gland activity.

Avoidance of chemical additives is suggested for everyone, but particularly allergy sufferers. Even though there may not be an allergy to any specific chemical, the body still has to detoxify these chemicals, adding to the burden on the liver and the endocrine glands.

The same principle holds true for environmental chemicals, hair sprays, room deodorants, chemical cleaners and other toxic substances that we are exposed to on a daily basis. Minimizing exposure to the above allergens reduce the burden on the liver and glandular system.

Conclusion

Our research indicates that the reason allergies are so common today is largely due to an adrenal burnout-induced imbalanced body chemistry. The body has become hypersensitive to foods and environmental chemicals, which cause many types of allergic reactions.

Body chemistry has become impaired due to inadequate diets, stress and environmental pollution. Today, children are born with toxic metal poisoning and nutrient deficiencies, which indicates that even if an individual eats well, they may still be afflicted with allergies.

March 3, 2007 Posted by | Health | , , , , , , , , | Leave a comment

Entry for March 03, 2007

I don’t appear to have any other symptoms of liver disease other than the yellow skin. So a bit more research and I uncover some new things…

WEAK LIVER

A weak liver can be the cause of many chronic health problems. Pain, constant fatigue, sleep disorders, heart palpitations, poor memory, skin problems, allergies, arthritis, thyroid problems, frequent urination, fainting and poor eyesight are a few examples of what may result when the liver is stressed.

The liver is the most emotion sensitive organ and its weakness is often connected to emotional sensitivity. Individuals who are emotionally sensitive are more prone to weak liver even if they do not have a poor diet or are not taken medication regularly.

Liver congestion and stagnation are common problems. Yet conventional medicine does not understand them and has no test to detect them. In hepatitis or liver inflammation, liver enzyme levels in the blood are elevated because of the ruptured liver cells which contain high contents of liver enzymes. However, in liver congestion or stagnation, liver cells are still intact and liver enzyme levels in blood are normal. Therefore normal clinical tests which rely on liverr enzyme levels as a measure of liver condition cannot detect liver congestion or stagnation.

LIVER CLEANSING

Chinese Gentian (Lung-tanTsao) has been known for thousands of years to be useful in the treatment of fever, rheumatism and general debility. It is also said to benefit the liver, aid digestion, strengthen the memory and give lightness and elasticity to the body. It is primarily used in the treatment of acute hepatitis, acute conjunctivitis, acute tonsillitis, jaundice and most liver disorders. It is also helpful in alleviating “sluggish liver” which can be caused by hormone therapy, medications or other problems such as stress or poor diets.

Nutritional deficiency is a common problem for individuals with liver disorders. Most nutrients pass through the body without being assimilated if the liver is weak. Supplements taken by individuals with weak livers may end up as waste products for the body to dispose because the supplements cannot be digested or assimilated.

I’ve mentioned the long term supplementation without any results to every doctor and how many mentioned liver function? You guessed it…not one. The nutrionist suggested a liver cleanse so I guess with my diet history it makes a lot of sense.

March 3, 2007 Posted by | Health | , , | Leave a comment

Entry for March 03, 2007

I went to the health food store to pick up some magnesium. They also had NuLife’s brand of potassium so I picked that up as well. When I went to pay at the cash, the guy behind the counter starting talking about supplements and asked us about our health. We talked about a bunch of things and then he asked me about the colour of my skin.

I wasn’t sure what he was talking about at first because I know my skin is slightly pale and one lady mentioned my pale complexion as an indication of mineral deficiencies.

He continued by saying that he thought my skin had a yellow cast to it and mentioned liver function. He continued by saying that the liver is most effected by stress and your emotional state. So I asked if something like Milk Thistle would help. He suggested drinking something called dandelion tea to help support the liver.

I’ve known about the possibility of a weak liver a while back based on the Chinese tongue analysis and it’s always bothered me because I’m always checking my tongue. More recently, the nutritionist suggested a liver flush to help with my adrenals.

My wife did actually notice my yellow skin a while back and it was just after we moved into our new house. The city of Markham is very high on using the new kind of energy effecient lightbulbs and our new house has them in almost every room. If you have ever used them, you may have notice that they have no constant colour cast so when my wife mentioned the yellow cast on my skin, I thought it was because of the new different kind of lighting.

I started taking supplements for candida at the begining of November just before the move so could it be possible that fighting candida was releasing toxins into my bloodstream causing stress on an already weak liver?

I always brush off any suggestion that my problems are stress related because I don’t have any stress except for dealing with the doctors with my health issues. I’ve never been a person to be effected by stress or to be in any kind of stressful situations whether it be at home or my work environments.

After we left the store, I was a little freaked out. My hands were cold and I felt kind of sick. I started thinking about what he said about the stress. If my body is in a state of nervous exhaustion, then any kind of stress would effect me in a way that wouldn’t be a problem in a normal, healthy person. I think he’s right, but not based on the actual stress, but the state of my body and I’ve been dealing with this state of nervous exhaustion for almost two years and I can’t imagine that not having an effect on the other parts of my body.

Two years ago during my doctor’s first appointment, he said that a vibration is usually caused by stress. Having to deal with him appointment after appointment, he never once showed any concern for this “stress” effecting my liver.

An interesting development but I’ll need to do more research.

March 3, 2007 Posted by | Health | , , , , , , , | Leave a comment

Entry for February 10, 2007

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Today I looked up the suggestion from the nutritionist: Liver cleanse.

Why Use a Liver Strengthening Formula?

The health and vitality of every organ, gland, and cell are dependent upon the liver. Even our intelligence, attitudes, emotions and vitality are largely related to the liver. Our ability to repel disease or recover from disease is very much associated with this incredible organ. The liver, along with the heart and brain, are the most important organs in our bodies. However, even the heart and the brain are dependent on the liver. No one can be healthy without a strong, clean liver.

Notice: Live-er. The name itself gives us an idea of how important this organ really is. It is the largest gland in the body, weighing about 4 pounds. According to some doctors, at least 85% of the Western World’s population have sluggish livers. 100% of people with cancer, AIDS, diabetes, heart problems, yeast infections, digestive problems, parasites, etc., probably have liver problems. Every organ, gland and tissue is dependent upon the liver, and the liver depends upon the digestive tract.

How Liver Problems Originate

Physiologically, we develop liver weakness after we have abused our bodies by long-term eating of acid-forming foods, processed foods and other unhealthy foods. These include foods that are unnatural to the human body, like meat, sugar, white flour, white rice, foods cooked in oil, etc. Bad diet gradually weakens our digestive system, and do you know what organ takes the brunt of a bad diet? Yes, the Liver. All the food that is absorbed from our intestines goes directly to the liver, by way of the portal vein. The liver and bowels then must deal with all the harmful chemicals from the bad food. Food colorings, preservatives, heavy metals, fried oils, partially digested proteins, etc., all take their toll upon our precious liver and digestive system. It is for this reason, that cleansing the bowels is absolutely the most important treatment in helping to rejuvenate the liver.

FOODS & THINGS THAT ARE THE WORST FOR THE LIVER:

  • Heavy Metals
  • Cod-liver oil
  • Oils not cold pressed
  • Alcohol Meat and animal fats
  • Lack of exercise
  • Foods cooked in oil Margarine
  • Chemotherapy
  • Coffee
  • Pasteurized milk
  • White sugar
  • All drugs
  • Excessive fatigue
  • Vaccines
  • Tobacco
  • Over cooking
  • Salt-Sodium Chloride
  • Chlorine from water
  • Sodium Fluoride from water
  • Over eating
  • Cooked wheat – especially white bread
  • Constipation alternating with diarrhea
  • Medications and food chemicals
  • Pesticides found in commercially grown produce

Emotions Affect the Liver, Too

More than any other organ, the liver is affected by negative thoughts and feelings. Anger, resentment, fear, and all their emotional tributaries harm the liver more than anything else. With the exception of injury, 99% of all disease has an association with toxic waste settlement in conjunction with unconscious negative thoughts and feelings. This is why when people cleanse or take herbs to cleanse and strengthen the liver, strong emotions surface. These cleansing reactions must occur if we are to rid ourselves of the cause of our problems.

A Toxic Liver Leads to Disease

Every vein from the digestive tract empties into the liver, which filters out toxins and waste. The skin and lungs are the body’s first line of defense against toxins; the bowel is next, then the liver. When the bowel is overburdened with the wrong foods and/or negative emotions that cause physical stress and toxicity, the liver must work overtime to save the life of the body.

If the liver is unable to perform its full function, it will not only become even more toxic, but all the other organs are challenged. Prior to the first sign of disease, the effectiveness of the liver has been reduced. First come negative thoughts and feelings that affect hormonal and nerve function, then toxins related to mental/emotional stress or poor diet. These cause congestion and contamination, which prevent the proper flow of oxygen and nutrients to cells, and make the cells unable to rid themselves of waste. This cycle exacerbates an already weakened digestive system, toxic bowel and sluggish liver. In terms of physiology, this is the core of disease.

February 11, 2007 Posted by | Health | , , | Leave a comment

Entry for July 19, 2006

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I decide to call the lab again for my test results. I give them my information and this time she says she cannot provide me with any information. She explains that the doctor’s office has to call to get any info. So I call the doctor’s office and leave a message to call me.

I call my regular doctor’s office and I leave a message to make an appointment. Maybe he can get me the test results. I always seem to be wasting my time at these walk in clinics. On the way home I pick up some liver for supper. I hate liver but I’ll try anything to solve this ongoing mystery.

A couple hours after dinner I am lying down and yup…I’m still vibrating. It’s almost like I can’t make it stop anymore.

July 20, 2006 Posted by | Health | , | Leave a comment

Entry for July 06, 2006

High Tylenol doses linked to liver woes

By CARLA K. JOHNSON, Associated Press Writer
Tue Jul 4, 7:24 PM ET

CHICAGO – Healthy adults taking maximum doses of Tylenol for two weeks had abnormal liver test results in a small study, researchers found, raising concerns that even recommended amounts of the popular painkiller might lead to liver damage.

In the study, 106 participants took four grams of Tylenol equivalent to eight extra-strength Tylenol tablets each day for two weeks. Some took Tylenol alone and some took it with an opioid painkiller. Dummy pills were given to 39 others.

There were no alarming liver test results among the people who took the placebos. But nearly 40 percent of people in all the other groups had abnormal test results that would signal liver damage, according to the study that appears in Wednesday’s Journal of the American Medical Association.

“I would urge the public not to exceed four grams a day. This is a drug that has a rather narrow safety window,” said a study co-author, Dr. Neil Kaplowitz of the University of Southern California.

Heavy drinkers should take no more than two grams daily, Kaplowitz said.

Another co-author, Dr. Paul Watkins of the University of North Carolina, said he’s less worried than Kaplowitz, noting that acetaminophen, the active ingredient in Tylenol, has been used for 50 years and has a good safety record.

The maker of Tylenol, McNeil Consumer & Specialty Pharmaceuticals, said its own research found much lower rates of abnormal liver results. The company’s studies tracked high-dose users over longer periods than did the new study.

“It doesn’t lead to liver disease and it usually resolves as patients continue to take acetaminophen,” said Dr. Edwin Kuffner, senior director of medical affairs at McNeil.

The researchers had been hired by the drug company Purdue Pharma LP, maker of the prescription painkiller OxyContin, to find out why abnormal liver tests were showing up in people testing a combination drug containing the acetaminophen and the opiate hydrocodone.

Purdue Pharma stopped its hydrocodone study early because of the abnormal liver tests. Researchers Watkins and Kaplowitz thought they would find the culprit in hydrocodone’s interaction with acetaminophen.

“Our jaws dropped when we got the data,” Watkins said. “It doesn’t have anything to do with the opiate. It’s good ol’, garden-variety acetaminophen.”

Acetaminophen is more popular than aspirin or ibuprofen. Each week, one in five U.S. adults uses it for pain or fever, a 2002 survey found.

Acetaminophen is included in numerous over-the-counter and prescription medications, making overdose possible as people unwittingly combine drugs. Overdoses of acetaminophen are the leading cause of acute liver failure.

“A week doesn’t go by when I don’t have to talk to someone about how much they’re taking,” said Kathleen Besinque of the USC School of Pharmacy.

Watkins said people considering switching painkillers should know that others have their own side effects, such as internal bleeding and stomach irritation.

New research under way at the University of North Carolina may determine if acetaminophen’s effect on the liver continues for long-term, high-dose users, or if the body adapts, Watkins said.

July 6, 2006 Posted by | Health | , | Leave a comment

   

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