Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for October 25, 2007

For a couple of weeks now I’ve been reading Braverman’s book “The Edge Effect”. I think it’s brilliant and it makes a lot of sense but I’m still trying to really understand it. From his self test, I appear to be low in Dopamine. One of the things I came across lately was the factors that can cause a Dopamine deficiency. Okay, now we are getting somewhere…

There are a lot of different things that can have an effect and I know for absolute certain that I had problems with seven of them. Magnesium, Iron, Zinc, Niacin, Vitamin D, excess Copper and adrenal insufficiency.

Dopamine deficiency

Dopamine levels may be low due to a combination of genetic and acquired reasons. Dopamine can be raised effectively using either nutrient based therapies or medications. Dopamine is synthesized form the amino acid tyrosine.

Factors which reduce dopamine levels:

  • Magnesium deficiency
  • Iron deficiency
  • Zinc deficiency
  • Vitamin B3 deficiency
  • Vitamin D deficiency
  • Excess copper levels
  • Adrenal insufficiency
  • Vitamin B6 deficiency
  • Vitamin C deficiency
  • Inadequate sleep
  • Glutathione deficiency
  • Chronic stress
  • Hypothyroidism
  • Lead, arsenic and cadmium exposure
  • Tyrosine (precursor) deficiency
  • Genetic dopamine receptor abnormalities
  • Chronic opioid, alcohol & marijuana use
  • Parkinson’s Disease
  • Influenza
  • Estrogen deficiency
  • Human growth hormone deficiency
  • Under-methylation

The only item on the list that I didn’t understand was the term “Under-methylation”. Here’s what I found:

Under-methylation/HISTADELIA

Individuals with high-histamine levels may be due to a metabolic imbalance that results from under-methylation. As a consequence, these individuals overproduce and retain excessive levels of histamine. Histamine is a substance in the body that has wide ranging effects. There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes, blood vessels, etc. For some individuals, high levels of blood histamine (called histadelia) have psychological, behavioral, and cognitive symptoms.

Many patients with obsessive-compulsive tendencies, “oppositional-defiant disorder,” or seasonal depression are under-methylated, which is associated with low serotonin levels. Often with inhalant allergies, frequent headaches, perfectionism, competitiveness and other distinctive symptoms and traits. Tend to be very low in calcium, magnesium, methionine, and vitamin B-6 with excessive levels of folic acid. People with histadelics have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters. Unfortunately, histadelics often have nasty side effects with these medications.

Histamine excess can be manifest as asthma, vasomotor rhinitis, allergic skin disorders with pruritis, excess stomach acid production (acts as a gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and bronchial secretions, and certain types of vascular headaches. This is the basis of anti-histamine medications. Excessive histamine results because of the inadequate methylation in liver detoxification. Histamine opposes adrenalin in its effects and as expected fatigue occurs just as it occurs in adrenal exhaustion.

Biochemical treatment revolves around antifolates, especially calcium and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.

Methylation is involved in DNA synthesis, masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve myelination, carnitine and coenzyme Q 10 synthesis. The relationship of mood and behavior to Histadelia is due to the fact that methylation is involved in neurotransmitter synthesis.

This is sounding too familiar… High-histamine levels. Something to look into further when I have more time.

Advertisements

May 22, 2008 Posted by | Health | , , , , | 3 Comments

Entry for October 05, 2007

Noticed another slight improvement with the candida today. So was it Acetyl-Carnitine or Theanine? That’s the one problem with wanting to take so many things…

While researching the amino acids I came across a health bulletin board where someone suggested reading a book called “The Edge Effect” and something called the “Braverman Test”. Basically, it’s a questionaire that can determine deficiencies in each neurotransmitter. This could be what I’ve been looking for but what is it exactly? Dr. Google?

The Braverman Nature Assessment

Dr. Braverman’s twenty-six years of medical education, training and clinical practice have focused on the brain’s overall health. Many common conditions have their origins in brain chemical imbalances. Each of the four main lobes of the brain has a primary biochemical, called a neurotransmitter that is responsible for a specific brain function. When you are ill, physician prescribe a medication, which restores a specific brain chemical to restore health. Natural substances however can do the same thing, because each of the primary brain neurotransmitter has a precursor, which the body used to manufacture each of the four brain chemicals. That is what prompted Dr. Braverman to develop his own line of nutrient-precursors that target each of these four brain chemicals.

Dominant
Section 1A = Dopamine Nature
Section 2A = Acetylcholine Nature
Section 3A = GABA Nature
Section 4A = Serotonin Nature

Deficient
Section 1B = Dopamine Nature
Section 2B = Acetylcholine Nature
Section 3B = GABA Nature
Section 4B = Serotonin Nature

November 24, 2007 Posted by | Health | , , , , , , , | Leave a comment

   

%d bloggers like this: