Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for August 29, 2006

From the prevous entry:

I ask him if there is any kind of test that could measure any kind of demyelination and he answered “No not really…”

Here’s what I found:

Nerve Conduction Velocity (NCV) Test

What is it?
A nerve conduction velocity test, also called a nerve conduction study, measures how quickly electrical impulses move along a nerve. It is often done at the same time as an electromyogram, in order to exclude or detect muscle disorders.

A healthy nerve conducts signals with greater speed and strength than a damaged nerve. The speed of nerve conduction is influenced by the myelin sheath the insulating coating that surrounds the nerve.

Most neuropathies are caused by damage to the nerve’s axon rather than damage to the myelin sheath surrounding the nerve. The nerve conduction velocity test is used to distinguish between true nerve disorders (such as Charcot-Marie-Tooth disease) and conditions where muscles are affected by nerve injury (such as carpal tunnel syndrome).

Why should I do it?
This test is used to diagnose nerve damage or dysfunction and confirm a particular diagnosis. It can usually differentiate injury to the nerve fiber (axon) from injury to the myelin sheath surrounding the nerve, which is useful in diagnostic and therapeutic strategies.

How is it performed?
During the test, flat electrodes are placed on the skin at intervals over the nerve that is being examined. A low intensity electric current is introduced to stimulate the nerves.

The velocity at which the resulting electric impulses are transmitted through the nerves is determined when images of the impulses are projected on an oscilloscope or computer screen. If a response is much slower than normal, damage to the myelin sheath is implied. If the nerve’s response to stimulation by the current is decreased but with a relatively normal speed of conduction, damage to the nerve axon is implied.

And perhaps the best of all…I found this about Benfotmaine. The supplement that the Neurologist had never heard of:

Shielding Nerve Structure

While most anti-AGE supplements rely on test-tube browning experiments as the evidence of efficacy, Benfotiamine has been proven in multiple real-world human and animal studies to reduce AGE formation and support tissue structure and function in diabetics.

Most impressively, many randomized, double-blind, placebo-controlled human trials have proven that Benfotiamine powerfully supports nerve function in diabetic neuropathy. In one trial, 24 people suffering with diabetic neuropathy took either Benfotiamine (plus doses of common B6 and B12 similar to those used in mutivitamins) or a look-alike dummy pill, spread out into three pills over the course of the day, for twelve weeks. The participants started with 320 milligrams of Benfotiamine per day for the first two weeks, followed by 120 milligrams for the rest of the trial. Before and after the trial, the function of patients nerve cells were tested using nerve conduction velocity (NCV) and vibratory perception threshold (which tests the nerves sensitivity by determining the lowest level at which vibrations applied at key nerve sites are first felt).

At the end of the trial, the vibration perception threshold had clearly improved by 30% in those who had taken the Benfotiamine supplements, while it had worsened in the placebo group by 5% at one site and by 32% at another. At the same time, people taking Benfotiamine experienced statistically significant improvements in nerve conduction velocity from the feet, even as this aspect of nerve function deteriorated in those taking the look-alike pills.

This is exactly why I don’t like doctors anymore.

August 29, 2006 Posted by | Health | , , , | Leave a comment

Entry for August 25, 2006

Came across two interesting things today from Doctor Google:

  • Boron is essential for proper magnesium metabolism.
  • Thiamine may be critical for magnesium metabolism and possibly selenium metabolism.

Could it be possible that the reason Benfotamine has such an effect was due to the connection with magnesium? I’ve also come across something called Coenzyme Q10. Here’s what I found:

Coenzyme Q10 is a substance naturally produced by the body, but is also contained in all plant and animal foods. This coenzyme is also known as ubiquinone. Coenzyme Q10 is an essential component of the body’s process that makes the energy molecule, also known as adenosine triphosphate (ATP), from the food we eat. If coenzyme Q10 levels are compromised so is the ability of the body to make energy. All body processes depend on energy and so, ultimately, does good health. CoenzymeQ10 has also been shown to possess antioxidant properties. Both coenzyme Q10 and the mineral magnesium are key nutrients in the production process that yields the energy molecule, known as ATP (adenosine triphosphate).

Found this review on Amazon regarding a book on Mitral Valve Prolapse called “Natural Therapies for Mitral Valve Prolapse.”

“My wife suffered from mitral valve prolapse for several years until we discovered the many healing benefits of appropriate nutrient supplementation. Now that we take chelated magnesium and coenzyme Q10 daily for heart health, her MVP symptoms have disappeared. Anyone wishing verification of the role of magnesium in mitigating the symptoms of mitral valve prolapse can find it discussed in Dr. Carolyn Dean’s excellent book The Miracle of Magnesium. Another excellent book which also discusses the role of supplemental magnesium in relieving MVP is The Magnesium Factor by Dr. Mildred Seelig.”

– David Schryer

I decide to see if I can contact David to find out what the dosage was for magenesium and Q10. I’m also curious to find out how long it took. I click on his profile to get his email address and it says he’s a retired research chemist! He may be the perfect person to talk to so I send him an email.

In the meantime, I’ll need to do some more research on the magnesium metabolism…

August 25, 2006 Posted by | Health | , , , , , | Leave a comment

Entry for July 23, 2006

Yesterday I took a smaller dose of Benfotamine and today I only took one with my dinner. I’m going to go back to using acidophilus for my B vitamins and not use Benfotamine at all unless I have to. My new system for absorption overnight seems to be working.

I still have the vibration but my eyes are a lot better today. I think I was taking too much Benfotamine and it was actually making things worse. The iridologist wanted me to take 6 a day so I wasn’t doing anything I wasn’t told to do.

What’s the point of taking 6 a day when it’s a fat soluble vitamin? That doesn’t make any sense!!

July 23, 2006 Posted by | Health | , , , , | Leave a comment

Entry for July 21, 2006

Into the doctor’s office again for the mysterious internal vibration. He walks into the room and since I haven’t seen him in six months he asks me how he can help me today. I explain that I still have the internal vibration and for the past six months, I’ve done my own research and have a hunch that it’s related to a Riboflavin deficiency. I continue my story with the effect of a supplement called Benfotamine and explain about how the B1 blood test came up normal.

He thought it was weird that I relied so much on a B1 suppliment when there wasn’t a deficiency. I’ve had the vibration for over a year now and he suggests going to see a Neurologst. With Benfotamine having an effect on my neurological symptoms, he suggests that I may have something called Wernicke’s Encephalopathy. I’ve come across Wernicke’s Encephalopathy before as you can get it from untreated Beriberi.

So I continue explaining my research about how vitamin B1 is essential for creating the myelin nerve sheaths and how a B2 deficiency can cause the reduction of them. One of the symptoms includes a vibration feeling along with dry itchy eyes that are sensitive to light and the chapped lips and how I’ve had both for years. I’ve been taking B complex and high doses of B2 for months with no improvment so I tell him about the fat soluble version of B2 called Riboflavin Tetrabutyrate. He pulls out one of his large medical books and he doesn’t find it listed. He pulls out a second, then a third.

One of the books mentions about the treatment of a Riboflavin deficiency using B2 injections. He can’t find the supplement in his medical books so he suggests that I try the pharmacies to see if they have it. If they do, he’ll write a percription for it. Failing that, he’ll do the injections.

This is great news!!! I check at the pharmacy in his building for Riboflavin Tetrabutyrate. They don’t have it in their computer but she suggests going to a hospital pharmacy as they might have more distributors to order from. Great idea! Sunnybrook is one of the largest hospitals in the city, it’s close by and on the way home.

I stop into the Sunnybrook pharmacy and ask for Riboflavin Tetrabutyrate. After a bit of research she pulls up nothing. One of Toronto’s largest hospitals and they don’t have it and can’t order it for me.

July 22, 2006 Posted by | Health | , , , | Leave a comment

Entry for July 21, 2006

It’s an hour before my doctor’s appointment and I use google one last time to see if I can find anything. Because of the positive effect of Benfotamine, I’m convinced that that I have something reducing the nerve sheaths in my head.

And with one quick search I come across the answer:

Effects of riboflavin deficiency on nerve fibers

Ultrastructural studies indicate that riboflavin deficiency induced by either dietary restrictions alone or with the addition of the antagonist galactoflavin severely affects the structural integrity of myelin lamellae. The degenerative process induced by riboflavin deficiency is time dependent. Nonmyelinated nerve fibers are not affected ultrastructurally by the deficiency. Cellular organelles of both myelinated and nonmyelinated nerve fibers remain intact and presumably functional.

Now it’s making a lot of sense. The B2 deficiency is causing the reduction of the myelin nerve sheaths and I need the extra B1 to build it up again. HOLY COW! Wait until I present this to my doctor!! I can’t believe it!!

I must admit I was a litle nervous about seeing my regular doctor. With the new research I found this morning, I’ll go the angle of a vitamin B2 deficiency, explain about Benfotamine and see if he can prescribe the fat soluble version called Riboflavin Tetrabutyrate.

Form in Dietary Supplements

What forms of vitamin B2 are found in dietary supplements?

Riboflavin is found in its simplest chemical form in most dietary supplements. However, when active in the body’s metabolic pathways, this vitamin usually takes the form of flavinadenine dinucleotide (FAD) or flavin mononucleotide (FMN). Both of these forms of vitamin B2 are water-soluble. One fat-soluble version of the vitamin, called riboflavin tetrabutyrate, has also been the subject of experimentation in treatment of riboflavin-related disorders, but is not widely available as a dietary supplement.

Nutrient Interactions

How do other nutrients interact with vitamin B2?
Vitamin B2 status is strongly affected by intake of vitamin B1. Adequate supplies of vitamin B1 can help increase levels of vitamin B2. However, very high levels of vitamin B1 intake can increase the loss of vitamin B2 in the urine. Other nutrients, especially iron, zinc, folate, vitamin B3 and vitamin B12 are not fully available in the body without adequate supplies of riboflavin.

Riboflavin assists in turning fats, sugars, and protein into energy. Riboflavin is needed to repair and maintain healthy skin. Riboflavin also assists in regulating bodily acidity. There are no diseases associated with a riboflavin deficiency. However, riboflavin deficiencies commonly accompany other vitamin deficiencies.

I’ve noticed for a while now that my itchy eyes are getting worse. I have to use eye drops at least five and six times a day. They have always been itchy and red but never like this. The vitamin A made a huge difference so why are my eyes so itchy? I think it’s linked to the high doses of Benfotamine and how it can actually cause an increase loss of B2 in the urine. I’ll cut down using the Benfotamine and see if that makes a difference.

Last weekend I picked up some vegetables for trying in my new juicer. It was a bit of work to get a little bit of juice but I enjoyed it. I made veggie juice from 1 cubumber, 1 beet, 2 stocks of celery and a bunch of baby carrots. Really nice sweet taste and it was better than I thought it would be.

July 21, 2006 Posted by | Health | , , , , | Leave a comment

Entry for July 20, 2006

I get a call from the doctor in the walk in clinic and the test results are in..FINALLY! The doctor has reviewed them and the results? NORMAL

What? I asked if she had all four results and she agreed that all four were now complete. Normal? How is this possible? I ask her to fax the results to my doctor since I am seeing him tomorrow.

No Beriberi. So why does Benfotamine have such an effect on my neurological symptoms?

I’ve checked the dosage to what the iridologist recommended. She divided my vitamins into two higher doses instead of three spread out during the day. And since I’ve been taking these divided doses, for the past two days I’ve had a weird mild chest pain around lunchtime. I haven’t bothered to replenish my niacin so could this be the problem?

I decide to take my night Benfotamine at lunch and the mysterious pain disappears almost instantly. What can I do now? If my Thiamine levels are okay why has the head pinching stopped never to return since I started Benfotamine? I’m starting to wonder if I’ll ever get an answer.

I’ll mention Riboflavin and Magnesium to my doctor tomorrow and let’s see where that leads… If that fails, I’ll ask for the referral to the Environmental Health Clinic to see Riina Bray.

How is it possible that a person who isn’t deficient in Thiamine need a Thiamine supplement???

July 20, 2006 Posted by | Health | , , , , , | 2 Comments


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