Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for February 24, 2007

and another link to prostaglandin? Bed wetting…

Hormone Imbalance Could Spur Some Bed-Wetting

By Steven Reinberg
HealthDay Reporter
Friday, December 1, 2006; 12:00 AM

FRIDAY, Dec. 1 (HealthDay News) — An imbalance in a hormone-like substance called prostaglandin could explain tough-to-treat bed-wetting in some children, Danish researchers report.

Most children have their bed-wetting controlled by a medication called desmopressin, which reduces the amount of urine they produce at night. But about 30 percent of kids don’t respond to the drug.

“Our understanding of bed-wetting is continuously improving, and we are getting better in helping children that suffer from the condition.” said lead researcher Dr. Konstantinos Kamperis, from the University of Aarhus, Denmark. “How the body treats salt may play an important role in the etiology of the condition.”

His team found that children with the type of bed-wetting that does not respond to desmopressin have more salt and urea in their nighttime urine, possibly caused by an imbalance of prostaglandin.

The report is published in the December issue of theAmerican Journal of Physiology-Renal Physiology.

Bed-wetting is a common and bothersome problem. In fact, 5 million to 7 million children in the United States ages six and over wet their beds at night, according to the National Kidney Foundation.

In the study, researchers studied 46 seven-to-14-year-old children suffering from bed-wetting, all of who were treated as outpatients at Aarhus University Hospital. The youngsters had not responded to desmopressin. This group was compared to 15 children of similar age who had no bed-wetting problem.

The children spent two nights at the hospital. The first night was to acclimatize them to the hospital environment. During the second night, the researchers collected blood and urine from the children without waking them.

“We found that bed-wetters excrete larger amounts of salt at night, probably the reason for their bed-wetting,” Kamperis said. “Apart from that, these children excrete larger amounts of prostaglandins, and this could explain both the large excretion of salt at night as well as the inability of desmopressin to treat this condition,” he explained.

Compared with children who responded to desmopressin, the children who did not respond excreted twice as much urine during the night. In addition, the urine of children who wet their beds during the experiment contained more sodium, urea and prostaglandin than the other children, the researchers found.

“These findings point towards new treatment possibilities for bed-wetting with agents that reduce the amount of salt excreted in urine,” Kamperis said. “Such studies are being conducted at the moment. Furthermore, we would be interested in researching the exact etiology of this excess nocturnal salt excretion. That could help our understanding of bed-wetting,” he added.

One expert thinks that, while it is possible that prostaglandin might be involved in bed-wetting, the data from this study can’t be used to change clinical practice right now.

“This study has some biological plausibility, because some studies suggest that prostaglandin inhibitors are useful in the treatment of bed-wetting,” explained Dr. Joseph G. Barone, an associate professor of pediatrics and urology at Robert Wood Johnson Medical School, New Brunswick, N.J. “Prostaglandin inhibitors include Motrin and Advil, but, in my experience, these medications have not been effective against bed-wetting,” he added.

Although bed-wetting is very common, there are few basic science studies on this condition, Barone said. “This study adds useful information to the medical literature, and it may lead to further studies. However, clinical recommendations cannot be made based on the results of this study,” he said.

Barone noted that desmopressin is not a cure for the problem. “It works in about 50 percent of cases, in my experience,” he said. “When desmopressin works, it is not a cure, just a Band-Aid. The theory is that desmopressin reduces the amount of urine at night, and the child does not, therefore, wet the bed.”

Bed-wetting continues to be a multifaceted condition that is commonly associated with developmental immaturity, Barone said. “The most compelling evidence that bed-wetting is developmental in nature is the child’s natural tendency to outgrow the problem in 99 percent of cases,” he said.

February 25, 2007 Posted by | Health | , | Leave a comment

Entry for February 04, 2007


After reading that sugar can have an effect on appendicitis, I decide to do some more research. My mother tells a story where I had really bad stomach pains when I was around seven years old. The doctor’s couldn’t find anything obviously wrong so one day it was so bad, she took me to the hospital emergency. There it was decided to do exploratory surgery to find out what the problem was. They came back with appendicitis and I had an appendectomy.

So here we go again…I’ve mentioned this to to every doctor so far because when I start with a new doctor, there is always the generic form that I need to fill out and the section that includes surgical procedures. How many mentioned that one of the causes of appendicitis was poor diet? Not one.

I always knew I had a long history of poor diet and high sugar I just never realized there was early warning signs at such an young age that of course went ignored.


In England and Wales, a study was performed to review whether low intake of fiber and high intake of sugar and meat may influence the development of acute appendicitis. The study evaluated the dietary habits of 49,690 patients diagnosed with acute appendicitis. Although no specific correlation was found with sugar or meat, the analysis did suggest that the more fresh and frozen green vegetables and fresh and processed tomatoes people ate, the less likely they were to develop appendicitis. The researchers concluded that eating green vegetables—particularly cabbages, cauliflowers, peas, beans, and Brussels sprouts—and possibly tomatoes may protect against appendicitis.

Another study reviewed the link between abdominal microbes and the immune system in children with acute appendicitis who had or had not been breastfed. Children (mean age 7 to 8 years) with acute appendicitis were less likely to have been breastfed over a long period of time compared to a group of randomly selected children from the same geographic area. The authors suggest that human milk may boost the immune system, and it may make infections and inflammation less severe.

Another early sign of health issues? I had bed wetting problems as a child and now I’m wondering if this was a sign of poor diet and even a sign of a copper imbalance even then?

Children’s Biochemistry

Every human being begins life as a fast oxidizer. This means their hair tissue calcium and magnesium levels are low in comparison with the tissue sodium and potassium levels. Some characteristics of fast oxidation include a rapid pulse and a high degree of nervous sensitivity or irritability. Fast oxidizing children are more active. Very fast oxidation produces extreme irritability, inability to relax and often aggressive behavior. Fast oxidizers require dietary fat and calcium such as that found in full-fat milk. Children may remain fast oxidizers for years. However, in general, as one ages the oxidation rate slows.


Children with a copper imbalance display this symptom more than other children. A copper deficiency or excess (biounavailability), can cause excessive nervousness that may result in poor bladder control. When the copper imbalance is corrected through a nutrition program, often the bed-wetting problem subsides.

Sugar and Carbohydrate Sensitivity

Many children are highly sensitive to sugar and any form of sweets in their diet. One reason for this is a fast oxidation rate. Fast oxidizers burn their food at a faster-than-normal rate. Many children are also born today with deficiencies of manganese, zinc, chromium and vanadium. These elements are involved in blood sugar regulation.

Sugar is a rapidly-absorbed food. When a high-sugar diet is coupled with a rapid rate of oxidation, it is like pouring gasoline on a fire. There is a dramatic rise in the blood sugar level, stressing the sugar regulation mechanisms and altering calcium and phosphorus levels. This can have profound effects upon mood and behavior.

Avoidance of all sugar-containing foods is a necessity for many children, especially those prone to strong sugar reactions. A diet high in sugar and carbohydrates also aggravates a chronic zinc and magnesium deficiency. Yet zinc and magnesium are precisely the minerals needed to help calm down these children. Fast oxidizers require a diet higher in fat and lower in carbohydrates. In some children, extra protein will help control blood sugar fluctuations.

Supplementing deficient minerals and feeding children a nourishing, appropriate diet for their oxidation type can help prevent and correct excessive sugar sensitivity.


Give your child foods high in silica, calcium and magnesium. Sesame seeds, almonds, porridge, milk pudding with figs and bananas are good sources of these minerals. Calcium and magnesium relax the system and can help counteract the nervous tension which often provokes bedwetting. All nutrients are important for healthy development of the body. Silica is highly recommended for strengthening the urinary tract, kidneys and bladder.

February 10, 2007 Posted by | Health | , , , , , | Leave a comment


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