Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for December 30, 2006

I’ve been telling my doctor for sometime now that I have some really low vitamin B deficiencies and luckily convinced him to give me a riboflavin injection. I noticed several improvements but he seems hung up on the anxiety diagnosis from the neurologist. Any research on B vitamins suggest that they all work together so if you have one deficiency, you’ll have several and my doctor didn’t seem interested in pursuing it any further.

Found this tonight from who else? Doctor Google:

Anxiety and the Vitamin B complex

Deficiencies of members of the vitamin B complex appear to be common in patients with agoraphobia (fear of open spaces). (1) The same is likely to be true for other anxiety-related conditions. We will review the evidence suggesting that individual members of this family may affect the experience of anxiety.

Inositol Supplementation

Inositol is a key intermediate of the phosphatidyl-inositol cycle, a second-messenger system used by several noradrenergic, serotonergic and cholinergic receptors. Since ingestion has been shown to raise inositol levels in the cerebrospinal fluid, this nutrient could potentially serve as an anti-anxiety agent.

Indeed, when a group of 21 patients with panic disorder either with or without agoraphobia received 12 grams daily of inositol or placebo in random order for 4 weeks each, the inositol supplement was associated with a significantly greater reduction in the frequency and severity of panic attacks and of agoraphobia than the placebo. Moreover, while the efficacy of the nutrient was judged to be comparable to that of imipramine, its side effects were minimal.

Niacinamide Supplementation

Niacinamide has been shown in an animal study to have benzodiazepine-like actions including anti-conflict, anti-aggressive, muscle relaxant and hypnotic effects. In contrast to niacin, it passes readily from the plasma to the cerebrospinal fluid where it is taken up into brain cells by a high-affinity accumulation system, suggesting it is the preferred form of vitamin B3 for the treatment of anxiety.

Lactate (which is associated with anxiety) reacts with niacinamide-adenine dinucleotide [NA[D.sub.+]] to form pyruvic acid and reduced NAD (NADH + [H.sup.+]). The equilibrium of this reaction favors lactate and NA[D.sup.+]), but it can be driven by adding excess NA[D.sup.+]. It may be that supplementation with niacinamide helps to drive the reaction, thus reducing lactate concentrations.

Anecdotal reports suggest that niacinamide has anxiolytic effects comparable to the benzodiazepines, and it may be particularly effective for patients whose anxiety is secondary to reactive hypoglycemia. Typical dosages are between 500 mg twice daily and 1,000 mg 3 times daily. Hoffer believes that the optimal daily dosage is just below the amount that produces nausea.

Thiamine Deficiency

Elevated lactate may also be caused by inadequate pyruvate dehydrogenase activity resulting from a thiamine deficiency or dependency. In that case, the conversion of pyruvate to acetyl CoA is inhibited, fostering its conversion to lactic acid. Symptoms of a prolonged moderate thiamine deficiency may include fearfulness progressing to agitation as well as emotional instability and psychosomatic complaints.

When more than 1,000 healthy young men were studied, those who were chronically borderline thiamine-deficient were currently feeling significantly more anxiety–although they were not customarily nervous individuals. There are no published studies on the repletion of a borderline thiamine deficiency to treat anxiety.

Vitamin B6 Deficiency

Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter which is involved in the regulation of anxiety, requires vitamin B6 for its synthesis; thus a deficiency of this vitamin may theoretically result in heightened anxiety. Vitamin B6 is also required for the conversion of tryptophan to serotonin, a neurotransmitter suspected of being involved in anxiety.

When over 1,000 healthy young men were studied, those found to be chronically deficient in vitamin B6 had a significantly greater tendency to become anxious, although they were not significantly more anxious at the time of the study. Also, in an open trial, patients with hyperventilation syndrome who also had abnormal xanthurenic acid excretion (an indicator of vitamin B6 deficiency) improved following the administration of pyridoxine and tryptophan, suggesting that a marginal B6 deficiency, by causing serotonin depletion, may have produced the syndrome.

Vitamin B12 Deficiency

Anxiety may be part of the neuropsychiatric syndrome seen in advanced cases of pernicious anemia which is well-known to be caused by B12 deficiency. When cobalamin levels of more than 1,000 healthy young men were studied, those who were chronically borderline vitamin B12-deficient were significantly more anxious at the time of the study–although they were not customarily nervous individuals. Whether B12 supplementation reduces anxiety when the vitamin is borderline deficient remains to be investigated.

References

1. Abbey LC. Agoraphobia. J Orthomol Psychiatry 11:243-59, 1982

2. Benjamin J et al. Inositol treatment in psychiatry. Psychopharmacol Bull 31(1):167-75, 1995a

3. Levine J et al. Inositol treatment raises CSF inositol levels. Brain Res 627(1):168-70, 1993

4. Benjamin J et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 15(7):1084-6, 1995b

So I’ve had a blood test for vitamin B12 and Thiamine and both were normal. Still waiting on the results from the vitamin B6 test. I’ve long discovered the Niacin deficiency with some great results but not for anxiety and Inositol I don’t know much about. I believe it’s included in B complex.

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December 30, 2006 Posted by | Health | , , , , , , , | 1 Comment

Entry for October 21, 2006

My doctor thinks I have anxiety. I would disagree however, I would say that my body is in a state of anxiety. I know I have these upward lines in my pupils and the iridologist was the first to mention anxiety and explain it. But nobody has mentioned that it can be caused by a B vitamin deficiency… Dr Google?

A deficiency of vitamin B6 (pyridoxine) causes extreme anxiety, nervousness, confusion, and melancholy. Vitamin B6 is easily destroyed by heavy use of alcohol, drugs and refined sugars.

A quick google search and I have the answer that I’m looking for. These doctors are so caught up in their world of drugs. If this B6 blood test comes back as extremely low then all of my problems are related a vitamin deficiency that nobody could figure out except me and doctor Google.

How embarrassing… Modern medicine is antiquated.

I’d love to order the injectable B6 vitamin from Romania and have it with me when he has the results of my blood test. I’ve been wrong before but my problem is I keep looking for the one thing that is causing my symptoms and that is my biggest problem: my symptoms are caused my a number of different deficiencies. Niacin, riboflavin, magnesium and now possibly pyridoxine?

My theory goes like this: My magnesium and B6 have been low for years and I believe that the combination low levels of B6 and magnesium caused the vibration/anxiety. Losing the B6 caused me to lose niacin and later riboflavin. Then I started taking B vitamins which helped but I was ignoring the magnesium.

Some more information:

Functions: Pyridoxine and its coenzyme form, pyridoxal-5-phosphate, have a wide variety of metabolic functions in the body, especially in amino acid metabolism and in the central nervous system, where it supports production of gamma-aminobutyric acid (GABA). Many reactions, including the conversion of tryptophan to niacinand arachidonic acid to prostaglandin E2 require vitamin B6. The pyridoxal group is important in the utilization of all food sources for energy and in facilitating the release of glycogen (stored energy) from the liver and muscles. It helps as well in antibody and red blood cell production (hemoglobin synthesis) and in the synthesis and functioning of both DNA and RNA. By helping maintain the balance of sodium and potassium in the body, vitamin B6 aids fluid balance regulation and the electrical functioning of the nerves, heart, and musculoskeletal system; B6 is needed to help maintain a normal intracellular magnesium level,which is also important for these functions. The neurotransmitters norepinephrine and acetylcholine and the allergy regulator histamine are all very important body chemicals that depend on pyridoxal-5-phosphate in their metabolism. Also, the brain needs it to convert tryptophan to serotonin, another important antidepressant neurotransmitter.

Pyridoxine is especially important in regard to protein metabolism. Many amino acid reactions depend on vitamin B6 to help in the transport of amino acids across the intestinal mucosa into the blood and from the blood into cells. By itself and with other enzymes, pyridoxal-5-phosphate helps build amino acids, break them down, and change one to another and is especially related to the production and metabolism of choline, methionine, serine, cysteine, tryptophan, and niacin.

The body has a high requirement for vitamin B6 during pregnancy. It is important for maintaining hormonal and fluid balance of the mother and for the developing nervous system of the baby. Pyridoxine may somehow be related to the development and health of the myelin covering of the nerves, which allows them to conduct impulses properly.

This is making so much sense that I feel really stupid for missing it. I shouldn’t really feel bad. It’s the doctors that are paid to figure it out, not the patient.

October 21, 2006 Posted by | Health | , , | Leave a comment

Entry for October 20, 2006

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Let’s find out about the side effects in more detail for “Paxil CR”. Here’s what the official web site says:

Important Safety Information

Prescription Paxil CR and Paxil are not for everyone. Don’t take with MAOIs, thioridazine, or pimozide. Paxil CR and Paxil are generally well tolerated. As with many medications, there can be side effects. Some of the side effects may include infection, injury, nausea, diarrhea, dry mouth, constipation, decreased appetite, sleepiness, dizziness, sexual side effects, nervousness, tremor, yawning, sweating, abnormal vision, weakness, or insomnia. Talk to your doctor if you are taking prescription medication known as triptans, which are used for migraine or cluster headaches. When used in combination with Paxil CR or other anti-depressant treatments, these drugs may lead to potentially life-threatening complications.

Paxil CR and Paxil are approved only for adults 18 years and over. In some children and teens, antidepressants increase suicidal thoughts or actions. Young adults, especially those with depression, may be at increased risk for suicidal actions. Whether or not you are taking antidepressants, you or your family should call the doctor right away if you have worsening depression, thoughts of suicide, or sudden or severe changes in mood or behavior (for example feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, hyperactive, overly excited, or not being able to sleep), especially at the beginning of treatment or after a change in dose.

Don\’t stop taking Paxil CR and Paxil before talking to your doctor since side effects may result from stopping the medicine, particularly when abrupt. Symptoms some patients have reported on stopping Paxil CR and Paxil include: dizziness, sensory disturbances (including electric shock sensations and tinnitus), abnormal dreams, agitation, anxiety, nausea, sweating, mood fluctuations, headache, fatigue, nervousness and sleep disturbances.

This is a very long list of side effects. In fact there are fourty side effects and I really don’t think it’s worth it for anxiety or not. My new magnesium is doing just fine with no side effects whatsoever. So he prescribed Paxil because I have general anxiety at the direction of the Neurologist which is funny because he didn’t recommend any medication to me. If fact, he made it appear that he was against it because it wouldn’t help me.

Let’s see what I can find out:

Anxiety, the body’s reaction to a perceived, anticipated or imagined danger or threatening situation, is a common occurrence. Most people experience it before or after a stressful event, such as an important presentation or a traumatic loss. A little anxiety isn’t always a bad thing, either: it can help motivate you to do your best and to respond appropriately to danger.

Sometimes, though, anxiety develops spontaneously, even when a stressful or threatening situation isn’t immediately apparent. When worry becomes so excessive and persistent that it limits or inhibits� a person’s daily activities, it becomes a disorder that needs to be recognized and treated.

What is generalized anxiety disorder (GAD)?
It’s only realistic to be worried about your finances after losing a job or your health if you start having chest pains. And it’s natural to be anxious about a sister who lives in a tough neighborhood or reports of a local flu epidemic or impending SATs. But generalized anxiety disorder isn’t about realistic or natural worries. GAD is about chronic, excessive worry concerning events that are unlikely to occur; it’s minor problems or concerns that wrap around your mind like kudzu and won’t let go.

Generalized anxiety disorder occurs when normal levels of anxiety become severe, prevent everyday activities, and persist over more than a few months. Normal life becomes difficult for people with GAD because they experience high levels of worry, dreading the immediate future and dwelling on what can go wrong, but feel unable to take action or control events. Generalized anxiety disorder affects 3 to 4 percent of the population at any given time, with women twice as likely to be affected as men.

According to the National Institutes of Mental Health (NIMH), persons with generalized anxiety disorder anticipate disaster and are overly concerned about health issues, money, family problems, or difficulties at work. A co-worker’s careless comment about the economy becomes a constant vision of an imminent pink slip; a spouse’s criticism of a new outfit becomes dread that the marriage is over. People with generalized anxiety disorder usually realize that their anxiety is more intense than the situation calls for, though some convince themselves that their worrying is protective or otherwise helpful. Either way, people with GAD can’t seem to turn off the worry. Sometimes just the thought of getting through the day produces anxiety. Most people with GAD don’t avoid workplace or social situations, but they go about their activities filled with exaggerated worry and tension, even though there is little or nothing to provoke them. For others, the anxiety and physical symptoms of generalized anxiety disorder interfere significantly with work, social interactions, and everyday functioning.

There is no way that the above description is anything like me and my wife agrees. What a joke. I didn’t see this direction coming…

October 21, 2006 Posted by | Health | , | Leave a comment

Entry for October 20, 2006 *D*

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All last night I was planning on what I would say to the doctor and I have a plan.

First thing he ask me about was if I had any tingling. Nope, not since the first riboflavin injection. Secondly he asked me about taking St. John’s Wort. Nope, did nothing for me.

I started telling him about how I did some experiments and I’d like to go in a new direction. He seemed very interested so I told him how I found a magnesium supplement that seems to be working better than any of the others and he was happy to hear about that. Then I told him about how I stopped taking the B vitamins and I’d get a weird feeling in my head. So I continued only with B6 and the weird feeling never came back. His face was more interested and he said if I suspected a B6 deficiency, then we can test for it. GREAT NEWS!

Then he told me how he would like to follow the recommendation from the neurologist. Huh? This caught me off guard because he never mentioned anything about him until now. He said he’d like to give me something called “Paxil CR” in a very small dosage to start. He mentions that it is used for depression and general anxiety disorders and continues about the side effects and that if I didn’t like it, I could stop taking it. He said it may not have any effect and on a scale of 0-10 it may only have an effect of a 2. Hardly seems worth taking but I agreed to continue with his approach if he took mine.

He wrote out a blood test for pyridoxine and added B12 and folic acid. Since it was a blood test, I asked him to check my level of triglycerides and he agreed but he said it would now need to be a fasting blood test.

I go down to the pharmacy and they fill out my prescription. As the pharmacist hands it to me she says how it may cause drowsiness and dizziness and says it could be three weeks until I feel any benefits.

Not so sure I like the sounds of the side effects so I call my wife and explain what happened. She looks it up on the internet and reads me a few more of the side effects including suicidal and mentions that there is a listing for it on crazymeds.com! She is adamant that she doesn’t want me taking this medication and I agree. We’re both confused as to why the doctor felt it was neccesary to take paxil when I clearly don’t have the symptoms to justify taking it.

The only symptoms I still have are an internal vibration and weak muscles. All of my other symptoms have disappeared though my own methods of vitamins and mineral supplements.

October 21, 2006 Posted by | Health | , , , , , , , , , , | Leave a comment

Entry for October 08, 2006

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The search if over! Less than two weeks after selling our house, we managed to buy a new one. Over 5000 metres from the hyrdo transmission towers and over 2000 metres from the nearest cell phone tower.

Not only that, but daddy daycare comes to an end after this weekend. Looking after a child is a lot of work and there were times when it wasn’t easy but overall, it wasn’t that bad and she’s a real easy baby to care for.

Again, I didn’t really feel the added stress had any effect on my symptoms and we were trying to sell our house and buy another one at the same time as daddy daycare was going on.

There is no way my symptoms are stress related. These doctors are out to lunch. So why do I have anxiety?

October 20, 2006 Posted by | Health | , | Leave a comment

Entry for September 12, 2006

Previous Night Vibration Status: Extremely Weak
Morning Vibration Status: Extremely Weak

Yesterday was my first day starting daddy daycare. I’ve decided to take four weeks parental leave from work to look after my daughter. Four weeks to enjoy my time off and maybe forget about my health issues for a while.

If I do have anxiety, the next four weeks should be very interesting…

September 12, 2006 Posted by | Health | , | Leave a comment

Entry for August 30, 2006

Previous Night Vibration Status: Extremely Weak
Morning Vibration Status: Extremely Weak

In the Anxiety kit from Shoppers Drug Mart and it talks about the chemical imbalance in more detail. So Doctor Google? I discover that deficient levels of magnesium and B vitamins can be a cause of a chemical imbalance. Interesting…that’s exactly what I told the neurologist… and he certainly didn’t offer any more information.

Understanding Chemical Imbalance

What is a Chemical Imbalance?

Over the course of the last three decades much research into the origins of emotional distress and disturbances have led researchers to embrace “chemical imbalance” as the leading cause. Though the exact mechanisms linking chemical imbalances and common disorders like anxiety, depression and ADHD are not completely understood, clinical studies and medical observations have been able to identify a number of chemical inconsistencies that occur in individuals who report experiencing symptoms related to these disorders.

Common chemical imbalances related to anxiety and depression related disorders that have been observed in clinical practice include:

  • Reduced availability of neurotransmitters like Serotonin, Dopamine, Norepinephrine, GABA and acetylcholine.
  • Increased levels of toxic neurochemicals such as Homocysteine.
  • Lower levels of serum Magnesium, Zinc or Potassium.
  • Unhealthy, or deficient levels of essential vitamins like B6, B9, B12 and Vitamin-C
  • Undersupply of key cofactors like amino acids that are used to help transport neurotransmitter precursors into the blood-brain barrier.
  • Increased cortisol stress hormone levels.

What causes chemical imbalance?

After researching the causes of a chemical imbalance online I came to the conclusion that no one, not even doctors, scientists or clinical researchers, knows what exactly causes a chemical imbalance. In fact, it was virtually impossible to come up with a single source that could provide conclusive evidence.

If you would ask a medical professional the reasons and causes for anxiety or depression, their answer would most likely be “A chemical imbalance…” As a result, the first impulse for most medical professionals and patients alike is to prescribe an SSRI, MAOI or similar “chemical balancer” to treat the condition.

August 30, 2006 Posted by | Health | , , , , | Leave a comment

Entry for August 29, 2006

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I was in Shoppers today and picked up some flax seeds. I’ll add them to my morning oatmeal. While I was in the store, I noticed a Healthwatch sign that mentioned talking to the pharmacist about anxiety. I head back to the pharmacy and pick up the Healthwatch Anxiety System Assesment kit. It comes with a questionaire and a symptom diary.

I showed the booklet to a bunch of my friends and they don’t agree with the diagnosis from the neurologist and they certainly don’t agree with the list of symptoms for anxiety.

But if I do have a “profile for anxiety” it’s just another symptom of a magnesium deficiency…

August 29, 2006 Posted by | Health | , , | Leave a comment

Entry for August 29, 2006

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The Neurologist…

He called my name as he entered the waiting room. It was his first appointment of the day and there was no one else in the room. I ask him if it’s okay to allow my wife to sit in with us and he agrees. He says he has very little on my symptoms and history so he’s eager to hear my story. The only thing he received from my doctor was that I had an internal tremor and that taking a supplement called Benfotamine was helping me. He had never heard of Benfotamine and I knew I was in trouble from this moment on…

I wanted to come prepared for this appointment but I just never had the time. I’ve explained my history of symptoms so many times that I’m confident that I can do it again without any notes. It all started with the internal vibration, the plantar fasciitis, indigestion and the stomach bloating. When I mentioned that I thought there was a link between the internal vibration and the plantar fasciitis, he gave me the smug doctor smile. “Another patient who thinks he knows what he’s talking about…”

I don’t mention the EMF exposure as I thought I would see how he reacts first. Then we talk about the successes: B vitamins, minerals, acidophilus and omega 3. He is writing notes the entire time I am talking. After I finish, he invites me into an examination room and performs a number of tests.

He holds a small bottle under my nose and asks me if I know what it is. It smells like lemon. He holds a second bottle under my nose and asks me the same question again. This time it has a minty smell and I’m correct again. He holds up three fingers and takes them down again real fast and he asks me how many I saw. He covers one of my eyes and asks me to read the smallest numbers on his eye chart. Switches to my other eye and does the same thing again. He then checks my reflexes on my wrists, knees and just above my feet. He shines a small flashlight into both of my eyes and asks me to follow his fingers. He turns off the lights and he shines the light into my eyes again. He turns the lights back on and everything took about ten minutes.

We walk back into his office and I sit beside my wife again. He starts by saying that I am an intelligent person and was very diplomatic in his speech. He said he could say with great confidence that I didn’t have any kind of neurological disease and talks about certain things I had mentioned. He asked about my parents, my marriage and the new baby.

He said he didn’t like to pigeonhole people but that I have a profile of anxiety. His recommendation was to seek help by seeing a psychologist or a psychiatrist. He said there was medication that could help me but the effects are not often seen for weeks. He cited the first child as being very stressful and that sometimes, for whatever reason, anxiety can be caused when there is a chemical imbalance within the brain but he didn’t think that was the case with me.

I added a few new things like the test that came back with a high level of free radicals and stressed adrenals. He nodded his head in agreement and said stressed adrenals is a classic symptom of anxiety. He asks if I have any further questions and I ask him if he thought a high level of free radicals could destroy the myelin sheath and he felt there wasn’t enough study in that field of research. I ask him if there is any kind of test that could measure any kind of demyelination and he answered “No not really…”

An internal vibration, tingling in my head and a neurologist tells me I have anxiety. What a complete waste of time. It’s possible I have anxiety now because I have to keep dealing with these know it all doctors who know nothing about nutrition but I am still looking for the root cause. I don’t have a stressful job, I’m not a person bothered by stress, in fact, I’m a very calm quiet person. Family life is good and I have a great group of close friends. If he thinks anxiety is the root cause of my internal vibration then he is completely wrong. My direct symptoms are never affected by any amount of stress.

It’s the classic case of a doctor looking for disease and when he doesn’t find anything obvious, the assumption is that everything is perfectly normal. Another doctor who has no interest in prevention. A ten minute exam and he comes back with anxiety. The only way he could’ve done that is to have used the pupil analysis and discovered those upward pointing lines that I saw in iridology.

When I left his office, I could tell my wife knew I wasn’t satisfied with his answers. In fact, I was furious.

I wasn’t mad about the diagnosis of anxiety, I was more pissed off because he didn’t seem to want to do anything to help me. I was under the impression that a Neurologist is a specialist who has a very advanced understanding about the human body. Well, not this one…

What a complete waste of time!! I feel like Charlie Brown and Lucy has just taken the ball away.

August 29, 2006 Posted by | Health | , , | Leave a comment

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