Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for December 09, 2007

I’ve written about Alzheimer’s in this blog in the past and it’s my belief that it can be caused by low levels of zinc. Low zinc levels can cause low magnesium and this will create other reactions in a weakened body that could eventually lead to Alzheimer’s. This guy talks about an enzyme called “MMP-9” that has the natural ability to attack the plaque found in Alzheimer’s. Turns out that they think this specific enzyme requires zinc to work properly. Thus a zinc deficiency would cause the buildup of plaque. Here’s an article that seems to support my theory.

Plaque and the Brain

Dr. Jin-Moo Lee, Assistant Professor of Neurology at Washington University School of Medicine in St. Louis has shown that another enzyme called matrix metalloprotease-9 (MMP-9) also degrades beta amyloid. Dr. Lee found that MMP-9 is able to break down the fibrils that make up the plaques found in Alzheimer’s. MMP-9 and other enzymes break down a free-floating kind of beta amyloid that hasn’t formed into plaques. But in Dr. Lee’s lab, the other enzymes didn’t seem to degrade fibrils the way MMP-9 did. These results suggest that MMP-9, already found in the body, may be helpful in clearing plaques from the brain.
 
It’s also not clear whether drugs designed to increase or decrease levels of MMP-9 could stop brain degeneration and dementia, or what any side effects would be. One possibility for therapy stems from the fact that MMP-9, like many other enzymes, requires the presence of zinc to work. So in theory, reducing the amount of zinc in the body via chelation therapy might inactivate MMP-9 and reduce damage to blood vessel walls. It’s unclear what this might do to the beta amyloid plaques in other areas of the brain, though, and there could be severe side effects. “Removing zinc would likely be detrimental to other systems,” says Dr. Lee.
 
The connection of MMP-9 to both Alzheimer’s and CAA is intriguing, but still murky. More research is needed before any treatments can be developed. “I think we are far from therapies at this point,” Dr. Lee says. “One must remember that at this level of research, we are trying to understand molecular mechanisms, and we are somewhat removed from therapies. However, our goal is to identify potential targets for the development of therapies. It’s too early to say whether MMP-9 will provide us with viable targets, but therapies to ameliorate disease are always on our minds.”

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May 30, 2009 Posted by | Health | , , | Leave a comment

Entry for August 13, 2007

I always wonder if I would’ve been diagnosed with Alzheimer’s disease or something else if I didn’t dive into the vitamins/minerals and take my own initiative to figure out what was going on?

Symptom Summary:

  1. High level of aluminum
  2. Zinc Deficiency / Magnesium loss
  3. DHA Deficiency
  4. Shrinkage of the Brain? (Osteopath)

Four very real symptoms of Alzheimer’s disease and I had them all. I totally believe they are all related to magnesium deficiency.

August 13, 2007 Posted by | Health | , | Leave a comment

Entry for August 13, 2007

One more thing about Alzheimer’s that bothers me is a person’s level of DHA. A magnesium deficiency can cause low levels of DHA.

Higher DHA Levels Associated With Reduced Risk Of Alzheimer’s Disease.

Results from a new study conducted at Tufts University suggest that having increased docosahexaenoic acid (DHA) levels in the blood and eating about three fish meals each week are associated with a significant 48 percent reduction in the risk of Alzheimer’s disease in elderly men and women.

The brain is composed mostly of fat, in particular, the Omega 3 fatty acid Docosahexaenoic acid (DHA). Patients with Alzheimer’s disease and other forms of dementia have shown very low concentrations of DHA in the brain indicating a possible DHA deficiency.

And the link to magnesium?

Magnesium has a multitude of different uses in the and is an essential cofactor of the enzyme delta 6 desaturase which converts vegatable derived omega 3 fatty acids to the brain critical omega 3 fatty acid DHA (docosahexaenoic acid) which is essential for the rapid release of dopamine. Thus if magnesium levels are low, DHA deficiency is very likely to exist.

August 13, 2007 Posted by | Health | , , , | Leave a comment

Entry for August 13, 2007

Another thing about Alzheimer’s disease is you always hear about the high levels of aluminum in Alzheimer patients but scientists don’t know why. I think it’s simple. Low level of zinc causes magnesium loss which causes the rising level of aluminum. 

This is from the Alzheimer’s Society website:

Aluminum

At the present time Aluminum is one of several factors scientists are investigating in the search for a cause of Alzheimer’s disease. The role of aluminum in the body and the brain is not well understood. Scientists disagree as to whether or not there is a connection between aluminum and Alzheimer’s disease.

And here is an article regarding magnesium’s role with aluminum.

The Aluminum – Magnesium Link

Research have suggested that aluminum may be more likely to accumulate in the brains of persons whose diets are magnesium-deficient — which, unfortunately, includes 90% of Americans! Several studies have shown that animals fed diets low in magnesium accumulate high concentrations of aluminum in the Central Nervous System. One of magnesium’s many functions is to activate the enzyme tubulin involved in the maintenance of nerve tissue cells. It has been suggested that when there is not enough Magnesium in the body to plug into the appropriate receptor site on the tubulin enzyme, aluminum takes its place instead. This leads to the inactivation of tubulin and, consequently, inadequate nerve function. Malic acid can pull aluminum away from this enzyme, making a place for magnesium. This may be a protection against Alzheimer’s disease.

Malic Acid is found abundantly in fruits such as apples. Malic Acid is also produced in the human body. It is a metabolite of the Krebs cycle the set of biochemical reactions used to produce 90% of all energy in the cells of the body. Malic Acid readily crosses the Blood-Brain-Barrier and has been shown to bind to aluminum. It functions in the body by drawing aluminum away from the tubulin enzyme, so that Magnesium can plug into the receptor sites instead. Malic Acid’s unique ability to bind with aluminum means it can be flushed out of the body, preventing unwanted build-up.

Because a Magnesium-deficient diet may increase the amount of aluminum taken up and stored by the body, it is vitally important that we take in sufficient amounts.

August 13, 2007 Posted by | Health | , , , | Leave a comment

Entry for August 13, 2007

In the beginning when I discovered vitamin and mineral deficiencies I read so much about magnesium and getting to understand the role it plays within the body. One of the things I kept running into was about is how magnesium loss played a role in Alzheimer’s disease.

There are a number of different factors for magnesium loss but from a first hand account I know now that a zinc deficiency can cause magnesium loss. When I came across this article I was mildly amused because zinc plays a role in the sense of smell. Made me wonder if warts are linked with Alzheimer’s? If they’re not, they should be…

Alzheimer’s linked to poor sense of smell

Study finds those who do poorly on odour tests more likely to show mental decline over time

Jul 03, 2007 04:30 AM
Associated Press

CHICAGO–Difficulty identifying common smells such as lemon, banana and cinnamon may be the first sign of Alzheimer’s disease, according to a study that could lead to scratch-and-sniff tests to determine a person’s risk for the progressive brain disorder.

Such tests could be important if scientists find ways to slow or stop Alzheimer’s and the memory loss associated with it. For now, there’s no cure for the more than 5 million Americans and estimated 300,000 Canadians over 65 with the disease.

Researchers have long known that microscopic lesions considered the hallmarks of Alzheimer’s first appear in a brain region important to the sense of smell. “Strictly on the basis of anatomy, yeah, this makes sense,” said Robert Franks, an expert on odour perception and the brain at the University of Cincinnati. Franks was not involved in the study, appearing in yesterday’s Archives of General Psychiatry.

Other studies have linked loss of smell to Alzheimer’s, Franks said, but this is the first one to measure healthy people’s olfactory powers and follow them for five years, testing for signs of mental decline.

In the study, 600 people between the ages of 54 and 100 were asked to identify a dozen familiar smells: onion, lemon, cinnamon, black pepper, chocolate, rose, banana, pineapple, soap, paint thinner, gasoline and smoke. For each mystery scent, they were given a choice of four answers. A quarter of the people correctly identified all the odours or missed only one. Half of them knew at least nine of the 12. The lowest-scoring quarter correctly identified eight or fewer of the odours.

The subjects took 21 cognitive tests annually over the next five years. Those who made at least four errors on the odour test were 50 per cent more likely to develop memory problems than people who made no more than one error. Difficulty identifying odours also was associated with a higher risk of progressing from mild cognitive impairment to Alzheimer’s.

August 13, 2007 Posted by | Health | , , | Leave a comment

Entry for October 20, 2006

Omega-3 fatty acids may slow very early Alzheimer’s

NEW YORK (Reuters Health) – Dietary supplementation with omega-3 fatty acids for 6 months appears to be of little benefit in patients with mild to moderate Alzheimer’s disease (AD), according to results of a study conducted in Sweden.

However, a second look at the data suggests that omego-3 fatty acids may protect cognitive function in patients with very mild, early stage AD.

Studies have shown that a diet rich in omega-3 fatty acids, as found in fish oil, reduces the risk of AD. Furthermore, animal studies have shown that the two predominant omega-3 fatty acids in fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), preserve cognitive function.

To evaluate the effect of DHA/EPA on patients already diagnosed with AD, investigators led by Dr. Jan Palmblad, from Karolinska University Hospital Huddinge in Stockholm, randomly recruited 174 patients with mild to moderate AD.

Eighty-nine patients were assigned 430 mg DHA plus 150 mg EPA, administered four times daily, and 85 were assigned placebo for 6 months during blinded portion of the trial. For the next 6 months, both groups were given the DHA/EPA supplement.

As demonstrated by Mini-Mental State Examination (MMSE) scores and the modified cognitive portion of the Alzheimer Disease Assessment Scale (ADAS-COG), the two treatment groups did not differ significantly at 6 months or at 12 months.

But when Palmblad’s group conducted a post-hoc analysis of the 32 patients with very mild AD at baseline, those first treated with placebo exhibited a significant decline in MMSE score at 6 months, whereas scores remained stable in those treated with DHA/EPA.

The researchers say their results, coupled with other studies, “support the idea that omega-3 fatty acids have a role in primary prevention of AD but not in treatment of manifest disease,” when the “neuropathologic involvement is too advanced to be substantially attenuated by anti-inflammatory treatment.”

SOURCE: Archives of Neurology October 2006.

October 21, 2006 Posted by | Health | , | Leave a comment

Entry for August 27, 2006

So here are some excerpts from Carolyn Dean’s book. I think the magnesium deficiency has never been more obvious and yet overlooked by every single doctor/specialist I have seen and overlooked by the alternative methods that I have tried.

Justification for a Magnesium Deficiency:

1) High level of free radicals.
2) High level of Aluminum.
3) Destruction of the Myelin sheath.
4) Long term use of vitamins with no real improvement.

Here is what she says in “The Miracle of Magnesium”:

PAGE 34:

Taking magnesium supplements with a fatty meal are a waste. Magnesium supplements are best taken on an empty stomach. There is much evidence that a high protein diet only makes a magnesium deficiency worse, and if you follow such a regimen, you should take at least 300 mg of supplemental magnesium a day.

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PAGE 118:

Sugar overload can cause magnesium deficiency in several ways. The body has to tap into it’s own reserves of minerals and vitamins to ensure sugar’s digestion. Adding sugar to the diet produces an excessively acid condition in the body; to neutralize it the body has to draw upon its stores of the alkaline minerals such as calcium, magnesium and potassium. If the acidic condition is severe, calcium and magnesium will even be taken from the bones and teeth, which leads to decay, softening, and ultimately osteoporosis.

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PAGE 144:

If you are taking estrogen and have a low magnesium intake, calcium supplementation may increase your risk of thrombosis. Calcium and magnesium: this minerals work so closely together that the lack of one immediately diminishes the effectiveness of the other. Even though the use of calcium supplementation for the mangement of osteoporosis has increased significantly in the last decade, scientific studies do not support such large doses after menopause. Soft tissue calcification could be a serious side effect of taking too much calcium.

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PAGE 169:

If the nerves are irritated by neurotoxins, they begin to lose their myelin sheath and MS can result.In fact, autoimmune disease may also be the end stage of a buildup of toxicity along with a deficiency of nutrients, such as magnesium that are designed to clear toxins from the body. According to some doctors, the definition of autoimmune disease as “disease against self” is not accurate; the disease process is, in fact, against a self altered by toxins and nutrient deficiencies.

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PAGE 170:

The overproduction of adrenaline due to stress leads to magnesium deficiency and therefore puts a strain on the magnesium dependent energy system of the body, causing energy depletion that leads to fatigue.

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PAGE 178:

The hallmark of a mineral deficient person is often one who takes vitamins without minerals and feels worse or does well for a while but then deteriorates. If you have a mineral deficiency, especially magnesium, which is necessary for energy production, certain areas of the body may be overstimulated by vitamin supplements, while other areas can’t respond. Begin with magnesium as one of your first supplements.

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PAGE 186:

Conventional allergy shots have been used for decades to try and trick the body into accepting irritating allergens but often do not work, especially when the condition is due to a nutrient deficiency.

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PAGE 193:

Antioxidants are vitamins and minerals such as magnesium, selenium, vitamin C and vitamin E that turn off free radicals. The greater amount of other antioxidants in the body, the more magnesium is spared from acting as an antioxidant and is free to perform it’s many functions. Antioxidants protect the level of magnesium in the body, which prevents elevation of calcium, which can lead to vascular muscle spasm. If there are not enough antioxidants available, overabundant free radicals begin to damage and destroy normal healthy cells.

According to current research, low magnesium levels not only magnify free radical damage but can hasten the production of free radicals. One study utilizing cultures of skin cells found that low magnesium doubled the levels of free radicals. It appears that low magnesium damages the vital fatty layer in the cell membrane making it more susceptible to destruction and allowing leakage through the membrane.

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PAGE 196/197:

Aluminum can also replace magnesium in the brain, which leaves calcium channels in the brain nerve cells wide open, allowing calcium to flood in, causing cell death. Enzymes function in the body only when they have access to the proper cofactors, which are mostly vitamins and minerals, especially magnesium, selenium, vitamin C, vitamin B6 and vitamin E.

Research indicates that ample magnesium will protect brain cells from the damaging effects of aluminum, beryllium, cadmium, lead, mercury and nickel. We also know that low levels of brain magnesium contribute to the deposition of heavy metals in the brain that heralds Packinson’s and Alzheimer’s. It appears that  the metals compete with magnesium for the entry into the brain cells. If magnesium is low, metals gain access much more readily.

There is competition in the small intestine for absorption of minerals. If there is enough magnesium, aluminum won’t be absorbed.

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PAGE 198:

William Grant, an atmospheric scientist, had an interest in Alzheimer’s because of a strong family history. Grant theorized that the diets of Alzheimer’s patients might be very acidic, leaching the calcium and magnesium from the body. He found that people with Alzheimer’s have elevated amounts of aluminum, iron and zinc and have reduced alkaline metals such as magnesium, calcium and potassium, which neutralize the acidity in the diet.

An acid forming diet is the typical western fare – high protein, high fat, and high sugar are additional factors in creating aluminum overload in Alzheimer’s.

August 27, 2006 Posted by | Health | , , , , | Leave a comment

   

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