Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for February 02, 2008

SAMe Is Essential For Brain Function

SAM-e (S-Adenosylmethionine) is an amino acid derivative that has been clinically proven.  Found in all living cells, SAM-e is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. The body makes SAM-e from the amino acid methionine and the cofactor vitamins B6, B12 and folic acid.

SAMe is the primary methyl donor available in the brain. Some of the biochemicals essential for proper nervous system function that benefit from SAMe include epinephrine, norepinephrine, serotonin and dopamine. Transmethylation in the brain includes actions upon the phospholipids that are the primary components of all cell membranes.

Supplementation with SAMe improves the body’s ability to manufacture phospholipids for use in the brain and helps keep neurotransmitters in balance.

Animal studies show that SAM-e increases levels of serotonin, but not the same way as SSRI or tricyclics work. They prolong the effect of a neurotransmitter by blocking its reuptake after it ferries a signal across the gap from one nerve cell to the next.

SAM-e, by contrast, appears to actually build neurotransmitters by donating part of its own chemical makeup, a methyl group. A common currency in metabolic processes, methylation also feeds the fats that stabilize nerve cell membranes and the receptors on them, making brain cells more responsive to a broad array of operations.

 I love this article for the comparison between Sam-e and Paxil (SSRI drug). I wonder if the neurologist knew this? Probably not. Who am I kidding?

After my discovery a few months back with the active form of B vitamins for better absorption, I’m always interested in supplements with higher absorption rates and SAM-e is no exception. A few days after taking SAM-e and there is a definate WOW factor. Once again, overnight my eyes feel stonger and my skin is so smooth and fantastic!

I think it’s safe to say the amino acid test is very accurate with a low level of methionine. Now if I can only find the other ones…


August 19, 2009 - Posted by | Health | , ,

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