Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for December 09, 2007

I’ve written about Alzheimer’s in this blog in the past and it’s my belief that it can be caused by low levels of zinc. Low zinc levels can cause low magnesium and this will create other reactions in a weakened body that could eventually lead to Alzheimer’s. This guy talks about an enzyme called “MMP-9” that has the natural ability to attack the plaque found in Alzheimer’s. Turns out that they think this specific enzyme requires zinc to work properly. Thus a zinc deficiency would cause the buildup of plaque. Here’s an article that seems to support my theory.

Plaque and the Brain

Dr. Jin-Moo Lee, Assistant Professor of Neurology at Washington University School of Medicine in St. Louis has shown that another enzyme called matrix metalloprotease-9 (MMP-9) also degrades beta amyloid. Dr. Lee found that MMP-9 is able to break down the fibrils that make up the plaques found in Alzheimer’s. MMP-9 and other enzymes break down a free-floating kind of beta amyloid that hasn’t formed into plaques. But in Dr. Lee’s lab, the other enzymes didn’t seem to degrade fibrils the way MMP-9 did. These results suggest that MMP-9, already found in the body, may be helpful in clearing plaques from the brain.
 
It’s also not clear whether drugs designed to increase or decrease levels of MMP-9 could stop brain degeneration and dementia, or what any side effects would be. One possibility for therapy stems from the fact that MMP-9, like many other enzymes, requires the presence of zinc to work. So in theory, reducing the amount of zinc in the body via chelation therapy might inactivate MMP-9 and reduce damage to blood vessel walls. It’s unclear what this might do to the beta amyloid plaques in other areas of the brain, though, and there could be severe side effects. “Removing zinc would likely be detrimental to other systems,” says Dr. Lee.
 
The connection of MMP-9 to both Alzheimer’s and CAA is intriguing, but still murky. More research is needed before any treatments can be developed. “I think we are far from therapies at this point,” Dr. Lee says. “One must remember that at this level of research, we are trying to understand molecular mechanisms, and we are somewhat removed from therapies. However, our goal is to identify potential targets for the development of therapies. It’s too early to say whether MMP-9 will provide us with viable targets, but therapies to ameliorate disease are always on our minds.”

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May 30, 2009 Posted by | Health | , , | Leave a comment

Entry for December 05, 2007

Found this interesting article about mosquitoes and amino acids.

“Why Do Mosquitoes Bite People?

Actually, only the female mosquitoes bite people. They are searching for isoleucine. Isoleucine is one of the basic building blocks of life called an amino acid. Amino acids are what make up proteins, and female mosquitoes need these proteins to make eggs. If they find isoleucine then they may lay as many as 100 eggs. But if they do not find isoleucine then they may only lay at most ten eggs.

So how do the mosquitoes find isoleucine? Isoleucine is part of our blood. The female mosquito punctures our skin with a part of her mouth known as her feeding stylets. Then she searches for blood vessels within our skin. A female mosquito usually finds a blood vessel in less than a minute. Next she sucks our blood through one mouthpiece. She can swallow up to four times her weight in blood, and when she is full she looks like a tiny red light bulb. She can do this because while she is sucking our blood, she is also injecting us with her saliva. There are special chemicals in her saliva which keep our blood from clotting.

Actually, human blood is not the best source for isoleucine. Blood from buffaloes and rats contains more isoleucine, but since people outnumber rats and buffaloes in many places the mosquitoes bite us instead.”

May 30, 2009 Posted by | Health | , , | Leave a comment

Entry for December 01, 2007

The Naturopath returns my email:
Sorry for the delayed response. We can go ahead and do the amino acid test. I have the kits at the clinic, so during your next visit, we can go through it and you can start it right after the visit. You should stop all supplements 48 hours prior to starting the test and eat what you normally eat (ie protein, etc).
 
There is just one concern – we have to freeze the sample for a minimum of 6 hours after collecting the urine for 24 hours before they come to pick it up. Could you put it in your freezer afterwards, and then I can arrange it to be picked up from the clinic.
Perfect! I’ll pick up the testing kit on my next appointment and get started! I book the next appointment for December 15th.

May 30, 2009 Posted by | Health | , | Leave a comment

Entry for November 27, 2007

The Naturopath got back to me today:

I have attached 3 files for you to review about the amino acid testing. The 24-hour urine amino acid collection is more accurate and detects an earlier change than the plasma amino acid test.

Attached is:
1. Description of the test
2. Collection instructions
3. Sample report/results so you can get an idea of what they test for.

The cost is approximately $230 + tax. Let me know if you are interested.

The first attachment:

Which type of analysis: urine or plasma?

The 24-hour urine amino acid analysis has the highest probability of detecting abnormalities if renal function is normal. The 24-hour test indicates what is high and low over the course of a day, reflects blood and tissue amino acid pools, and is not affected by circadian rhythm. Healthy kidneys efficiently conserve essential amino acids. Therefore, urine levels of amino acids decrease first and tend to give an earlier indication of inadequacy than do plasma levels.

A first morning void urine amino acid analysis, with results normalized per gram creatinine, provides an alternative when a complete 24-hour collection is not a viable option. The first morning void analysis is excellent for identification of marked abnormalities, particularly with respect to gastrointestinal health, inherited disorders in amino acid metabolism, and renal function, and can be used for protein challenge testing.

Plasma amino acid analysis measures what is being transported at the time of sampling. Abnormalities are deduced by comparison of measured levels with an established reference range. (The specimen should be collected after an overnight fast to reduce the influence of dietary protein). Plasma analysis is an excellent compromise if urine collection is difficult.

Looks like I’ll do the 24-hour urine test for the best results. If I am paying that much money, I want it to be as accurate as possible! The sample report looks interesting and contains NINE PAGES!!!

When do I start?!!! I’ve got to say it’s so much easier having a doctor I can have email correspondence with. I’ll send her an email to get the process started.

May 30, 2009 Posted by | Health | , | Leave a comment

Entry for November 25, 2007

Came across this article today about how high dosages of zinc can interfere with chromium absorption. Uh oh…

High dosage zinc interferes with Chromium

CHROMIUM BIOAVAILABILITY: Inorganic Chromium may be used therapeutically but organic forms of Chromium, e.g. GTF complexes, have higher biological activity.  This may partly explain some of the variance in the results of trials.  Phytate-rich diets possibly decrease Chromium absorption.  Chromium is required to metabolise sugar but sugar may increases the excretion of Chromium.  High dosage zinc supplementation possibly interfere with Chromium absorption.

Then I came across another article that suggested chromium will effect the amino acids.

Chromium and Amino Acid Metabolism

As part of Glucose Tolerance Factor (GTF), it works with insulin to regulate blood sugar levels. Diseases caused by a chromium deficiency include low blood sugar, diabetes, hyperinsulinemia, hyperactivity, learning disabilities, ADD/ADHD, hyperirratability, depression, bi-polar disease, impaired personality traits (bad seed), impaired growth, peripheral neuropathy, negative nitrogen balance (protein loss), elevated blood triglycerides, elevated blood cholesterol, coronary blood vessel disease, aortic cholesterol plaque, infertility and decreased sperm count and a shortened life span.
Chromium (GTF): Found in apples, black pepper, calves liver, cheese, meat and whole grains, grapes, cheese, chicken, corn and corn oil, dairy products, mushrooms, potatoes, beer, oysters, brown rice and dried beans.

BODY PARTS AFFECTED:
Adrenal glands, brain, blood, circulatory system, heart, immune system, liver and white blood cells.

DEFICIENCY SYMPTOMS:
Disturbed amino acid metabolism, increased serum cholesterol, impaired glucose tolerance, lack of energy, myopia, protein/calorie malnutrition, susceptibility to infection; Lowered or escalated blood sugar levels, coronary artery disease. It is essential to the metabolism of glucose and is needed for energy and the synthesis of cholesterol, fats and protein.

May 30, 2009 Posted by | Health | , | Leave a comment

Entry for November 24, 2007

Off to the Naturopath with my notes in hand. I’m expecting a lot and hoping for a miracle but I’m doubtful at the same time. I just want to put an end to this once and for all.

I explained my main reason for the appointment and that my hunch is that my potassium has gone too high because of multiple doses of arginine. Then, we spend a long time reviewing the notes on an item by item basis. I give her a date and a comment description and she’ll ask the occasional question and take her own notes. Understandably, this took a bit of time and we went through everything. I ended the summary by indicating my interest in amino acids and the possibility of a deficiency test. I also told her about a book I was reading called “The Edge Effect” by Dr.  Eric Braverman. Such a brilliant book but sadly, she had never heard of it.

The second part of the appointment was a medical exam. She had me sit down on the examination chair and she did a number of standard things and was very, very professional and even did the Chinese pulse diagnosis! She was very thorough when listening to my heart. I was very interested to know if she could hear the mitral valve prolapse (Also called Right Branch Bundle Block.) She said she could hear it but it was very faint.

She would do some research regarding the treatment of high potassium levels and get me with a price for the amino acid test. I like her. She seems to listen and is okay following my direction. I’m very interested in the amino acid test, if it’s accurate.

May 30, 2009 Posted by | Health | , , , , , | Leave a comment

Entry for November 23, 2007

Three days at the new job and I love it here. People are great and I love the fact that I work in the middle of a forest. No longer troubled with the hassles of the transit commute or the traffic congestion in the downtown core. And now that I’m into my new job, I’d really like to get my symptoms under control. I did a little research about how chromium can reduce potassium and copper levels in the body and I know I have some around so I take some in the morning with breakfast.

Chromium & Potassium

Magnesium levels frequently go up following long-term supplementation of chromium because of its synergism with chromium, and also because of potassium (which is a magnesium antagonist) going down, and thus not exerting an inhibiting effect on magnesium any longer.
 
Chromium is the “Gold Standard” to help normalize elevated copper, since it is its associated trace element. More aches and pains, arthritis, slow-healing fractures, sciatica and other back problems, various infections, etc, can be relieved with chelated chromium (not GTF), than with many other supplements – provided they conform to the side-specific requirements (see introduction above), provided that calcium and magnesium are close to normal, since they are also involved with various disorders of the musculoskeletal system, and provided that potassium levels are not below normal, since chromium is a potent potassium antagonist.

When supplementing chromium, its level will generally not increase at first, but instead it will gradually lower copper, and in the example below, potassium, since they are high in ratio to chromium.  Only after copper and potassium have been reduced to normal levels, chromium may at that point start to go up.  However, since sufficient amounts of chromium are rarely used, in practice, copper and potassium just come down closer to normal, and chromium levels stay the same.

I end up having cold hands all morning so is it because of the stress of the new job or because I took one dose of Chromium? Or something else?

I start calling around looking for a naturopathic doctor and I found someone local who has an opening for tomorrow. Fantastic!! I’ll have to gather all of my notes and be sure to include a brief overview of my health history and that could take a while but I want to make sure I get it right this time.

May 30, 2009 Posted by | Health | , , , | Leave a comment

Entry for November 21, 2007

First day on the job and I spend twenty minutes going around meeting everyone. I suppose I was a little nervous and my hands were so cold as I shook everyone’s hand. What an introduction.

May 30, 2009 Posted by | Health | , | Leave a comment

Entry for November 06, 2007

On the one hand I’m really excited about the new job. On the other, I’m really dreading the fact I have to submit my notice today although I’ve been thinking of the easiest way to do it for the past few days.  All morning I’ve had the worse case of cold hands I’ve ever had and tried everything to make it stop and nothing has any effect. My nerves must know what’s really going on. I feel okay so it’s just a mental issue that only I can resolve. A few close friends know that I’m about to quit today and they’re not helping the situation.

I finally get the chance to pull my manager aside and explain that I’d like to give in my notice. After the meeting I felt so relieved. He’s a great manager so it was really no trouble at all. That’s it, it’s done. Time to prepare for the new job and move on.

May 30, 2009 Posted by | Health | , | Leave a comment

Entry for November 05, 2007

I GOT THE JOB!!!!!!!!!!!

(And now for the hard part…)

May 30, 2009 Posted by | Health | Leave a comment

Entry for November 05, 2007

I received a follow up from the job interview last week and they would like a second interview. I was even more confident this time and was very careful to follow the same routine as last time. Vitamin C and acidophilus in the morning, calcium/magnesium around lunch and homeopathic tablets in the pockets during the interview.

Here we go!

May 30, 2009 Posted by | Health | , , , , | Leave a comment

   

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