Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for October 25, 2007


For a couple of weeks now I’ve been reading Braverman’s book “The Edge Effect”. I think it’s brilliant and it makes a lot of sense but I’m still trying to really understand it. From his self test, I appear to be low in Dopamine. One of the things I came across lately was the factors that can cause a Dopamine deficiency. Okay, now we are getting somewhere…

There are a lot of different things that can have an effect and I know for absolute certain that I had problems with seven of them. Magnesium, Iron, Zinc, Niacin, Vitamin D, excess Copper and adrenal insufficiency.

Dopamine deficiency

Dopamine levels may be low due to a combination of genetic and acquired reasons. Dopamine can be raised effectively using either nutrient based therapies or medications. Dopamine is synthesized form the amino acid tyrosine.

Factors which reduce dopamine levels:

  • Magnesium deficiency
  • Iron deficiency
  • Zinc deficiency
  • Vitamin B3 deficiency
  • Vitamin D deficiency
  • Excess copper levels
  • Adrenal insufficiency
  • Vitamin B6 deficiency
  • Vitamin C deficiency
  • Inadequate sleep
  • Glutathione deficiency
  • Chronic stress
  • Hypothyroidism
  • Lead, arsenic and cadmium exposure
  • Tyrosine (precursor) deficiency
  • Genetic dopamine receptor abnormalities
  • Chronic opioid, alcohol & marijuana use
  • Parkinson’s Disease
  • Influenza
  • Estrogen deficiency
  • Human growth hormone deficiency
  • Under-methylation

The only item on the list that I didn’t understand was the term “Under-methylation”. Here’s what I found:

Under-methylation/HISTADELIA

Individuals with high-histamine levels may be due to a metabolic imbalance that results from under-methylation. As a consequence, these individuals overproduce and retain excessive levels of histamine. Histamine is a substance in the body that has wide ranging effects. There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes, blood vessels, etc. For some individuals, high levels of blood histamine (called histadelia) have psychological, behavioral, and cognitive symptoms.

Many patients with obsessive-compulsive tendencies, “oppositional-defiant disorder,” or seasonal depression are under-methylated, which is associated with low serotonin levels. Often with inhalant allergies, frequent headaches, perfectionism, competitiveness and other distinctive symptoms and traits. Tend to be very low in calcium, magnesium, methionine, and vitamin B-6 with excessive levels of folic acid. People with histadelics have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters. Unfortunately, histadelics often have nasty side effects with these medications.

Histamine excess can be manifest as asthma, vasomotor rhinitis, allergic skin disorders with pruritis, excess stomach acid production (acts as a gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and bronchial secretions, and certain types of vascular headaches. This is the basis of anti-histamine medications. Excessive histamine results because of the inadequate methylation in liver detoxification. Histamine opposes adrenalin in its effects and as expected fatigue occurs just as it occurs in adrenal exhaustion.

Biochemical treatment revolves around antifolates, especially calcium and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.

Methylation is involved in DNA synthesis, masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve myelination, carnitine and coenzyme Q 10 synthesis. The relationship of mood and behavior to Histadelia is due to the fact that methylation is involved in neurotransmitter synthesis.

This is sounding too familiar… High-histamine levels. Something to look into further when I have more time.

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May 22, 2008 - Posted by | Health | , , , ,

3 Comments »

  1. This sounds like me. I’ve suffered for years. I’m a RN. Can I get into trials if I Prove positive for th dx.

    Comment by rebecca singleton | January 20, 2010 | Reply

  2. I have a dopamine deficiency diagnosed when I was 19. Are you taking anything for it?

    Comment by honesty556 | December 18, 2010 | Reply

    • Hello! I just read your post about your Dopamine Deficiency (very interesting reading). For me, I can’t really say if my problems were related to dopamine. I found a lot of the symptoms were too generic to be absolutely certain and by the time I came across this theory, I had given up going to doctors for any kind of a diagnosis. Did I take anything for it? Nope. But I did correct a number of imbalances related to this post. I can say with 100% certainty that I had the following deficiencies: Magnesium deficiency, Iron deficiency, Zinc deficiency, Vitamin B3 deficiency, Vitamin D deficiency and excess copper levels.

      I would really really recommend you read the book “The Edge Effect” by Eric Braverman. He is brilliant understanding the effect of amino acids and their effect on neurotransmitters and how they effect the brain.

      Comment by aaronjreid | December 18, 2010 | Reply


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