Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for May 20, 2007


Brazil nuts: an effective way to improve selenium status

From the Department of Human Nutrition, University of Otago, Dunedin, New Zealand

Background: Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans.

Objective: We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine.

Design: A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to provide 100 µg Se, 100 µg Se as selenomethionine, or placebo daily for 12 wk. Actual intake from nuts averaged 53 µg Se/d (possible range: 20–84 µg Se). Plasma selenium and plasma and whole blood glutathione peroxidase (GPx) activities were measured at baseline and at 2, 4, 8, and 12 wk, and effects of treatments were compared.

Results: Plasma selenium increased by 64.2%, 61.0%, and 7.6%; plasma GPx by 8.3%, 3.4%, and –1.2%; and whole blood GPx by 13.2%, 5.3%, and 1.9% in the Brazil nut, selenomethionine, and placebo groups, respectively. Change over time at 12 wk in plasma selenium (P < 0.0001 for both groups) and plasma GPx activity in the Brazil nut (P < 0.001) and selenomethionine (P = 0.014) groups differed significantly from the placebo group but not from each other. The change in whole blood GPx activity was greater in the Brazil nut group than in the placebo (P = 0.002) and selenomethionine (P = 0.032) groups.

Conclusion: Consumption of 2 Brazil nuts daily is as effective for increasing selenium status and enhancing GPx activity as 100 µg Se as selenomethionine. Inclusion of this high-selenium food in the diet could avoid the need for fortification or supplements to improve selenium status.

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May 20, 2007 - Posted by | Health | ,

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