Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for January 12, 2007

When I get home I start googling Ps-100 and it turns out that it’s not phosphorus at all! Ps-100 is actually something called phosphatidylserine. And here is what I find out:


Phosphatidylserine is a vital component of cell membranes and is the major acidic phospholipid in the brain. Its fluid nature, which is necessary for cell to cell communication and cellular metabolism, underscores the importance of this compound in cell membrane function and integrity.

This phospholipid has broad effects in the central nervous system. Administering preparations of phosphatidylserine to aged rats has increased dopamine release in the striatum, stimulated acetylcholine secretion, and has prevented age-related atrophy of cholinergic cells in the basal forebrain. Phosphatidylserine supplementation has demonstrated changes in EEG activity in humans. As well, taking PS over a period of 30 days has restored the circadian rhythmicity of thyroid-stimulating hormone (TSH) secretion in hospitalized patients.

This familiarly-called “brain nutrient” supports cognitive function, emotional well-being and behavioral performance by restoring cell membrane composition. It has also been shown to support memory. In a double blind placebo controlled multicenter study of 425 individuals, daily supplementation of phosphatidylserine over six months resulted in statistically significant support of behavioral and cognitive parameters.

In another six-month study of 40 individuals, phosphatidylserine supplementation enhanced cerebral metabolism and outcomes of cognitive training. These findings are consistent with earlier studies. In a placebo- controlled investigation of 149 subjects, the group receiving phosphatidylserine scored higher than placebo in performance tests related to memory tasks of daily life. In a trial of 35 subjects, those receiving phosphatidylserine exhibited behavioral support after six months. Pure Encapsulations unique formula contains 95-98% phosphatidylserine, the highest concentration available.

Phosphatidylserine may reduce the risk of dementia in the elderly. Very limited and preliminary scientific research suggests that PS may reduce the risk of dementia in the elderly.


An interesting application of phosphatidylserine is in addressing stress. In a double- blind study of healthy men, phosphatidylserine was administered to half of the participants10 minutes before starting exercise (physically induced stress). [14] The treatment standard was set at administering 50 or 75 milligrams of bovine-cortex phosphatidylserine (BC-PS) intravenously, or oral placebo. The results showed that pretreatment with both 50 and 75mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress.

Another study examined the effect of an oral supplementation of BC-PS on physically induced stress. [15] Healthy subjects took 800mg per day for 10 days. Again, BC-PS significantly blunted the ACTH and cortisol responses to physical exercise without affecting the rise in plasma growth hormone and prolactin.


January 13, 2007 - Posted by | Health | ,

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