Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for January 13, 2007

A serotonin deficiency can cause nervousness and sugar cravings. And a deficiency can be caused by low magnesium and low niacin levels among aother things. Interesting reading…

Serotonin deficiency signs/symptoms:

Depressed
Nervous/worrier/can’t relax
Fears/phobias
Negative/pessimistic
Irritable/impatient/edgy
Obsessive compulsive tendency
Self destructive or suicidal thoughts/plans
Low self esteem/confidence
Rage/anger/explosive/assaultive
Sleep problems/light sleeper
Feel worse in & dislike dark weather
Crave sugar/carbs/salt/alcohol/marijuana
Chronic pain (e.g. headaches, backaches, fibomyalgia)
PMS
Antidepressants or 5-HTP improve mood

Factors which reduce serotonin levels:

Stress
PCB’s, pesticides and plastic chemicals exposure
Under-methylation
Inadequate sunlight exposure
Tryptophan (precursor) deficiency
Iron, calcium, magnesium, zinc, B3, B6, folate & vitamin C deficiency
Inadequate sleep
Glutathione deficiency
Chronic infections
Genetic serotonin receptor abnormalities
Chronic opioid, alcohol, amphetamine & marijuana use
Human growth hormone deficiency
Progesterone deficiency
Impaired blood flow to brain
Insulin resistance or deficiency

Advertisements

January 13, 2007 Posted by | Health | , , , , , | Leave a comment

Entry for January 13, 2007

I remember running out of my omega 3 supplement for the first time and I had starting having weird symptoms. I figured at the time it was the omega 3 that was helping me but I could never figure out why. The answer? Low magnesium:

Magnesium has a multitude of different uses in the and is an essential cofactor of the enzyme delta 6 desaturase which converts vegatable derived omega 3 fatty acids to the brain critical omega 3 fatty acid DHA (docosahexaenoic acid) which is essential for the rapid release of dopamine. Thus if magnesium levels are low, DHA deficiency is very likely to exist. Low levels of serotonin in the brain are connected with low levels of the Omega-3 fatty acid DHA. This can again lead to increased stress and depression.

So now I’m wondering if my non refreshing sleep is from a serotonin deficiency from years of low magnesium?

There are basically two ways to rectify the Serotonin Deficiency Syndrome. One method is through the natural method of increasing tryptophan intake and the other through the use of anti-depressant medications such as Prozac. This is where the story gets very interesting.

There is a class of pharmaceutical medications called Selective Serotonin Reuptake Inhibitor (SSRI) anti-depressants. SSRI anti-depressants include Prozac, Paxil, Zoloft and others. Their method of treatment is to concentrate existing levels of serotonin in the brain so they stay in the synapse between nerves and facilitate communication. They do not create serotonin, as many people believe, but simply collect the existing serotonin so it is used more effectively. Some studies suggest that long term use of SSRI anti-depressants actually reduce serotonin levels. Serotonin levels are often low among people with anxiety disorders.

Our body chemistry is complex; many different hormones, neurotransmitters, and other substances influence how we feel. Serotonin is one chemical that has received a great deal of attention for its contribution to mood. It’s a neurotransmitter (a chemical involved in the transmission of nerve impulses between nerve cells) that’s formed in the brain and primarily found in three parts of the body — the brain, the lining of the digestive tract, and in blood platelets. In the brain, serotonin’s main effects include improving mood and giving you that “satisfied” feeling from food. It’s also thought to help promote sleep and relaxation.

Carbohydrate-rich meals often increase serotonin levels. However, manipulating serotonin levels through food may be very difficult to achieve because serotonin’s properties may have varying effects in different people. Some people may experience a temporary lift in mood after a carbohydrate-rich meal, while others may become relaxed or sleepy. Certain foods that increase serotonin levels aren’t the healthiest choices either. Believe it or not, candy and sweets, which are simple carbohydrates, have the greatest impact, but the effect will only last 1 – 2 hours. Complex carbohydrates (rice, potato, pasta) may increase serotonin levels, but not to the same extent because the protein content of these foods might actually inhibit serotonin production.

The  doctor wants me on Paxil but doesn”t really explain why except that it was recommended by the Neurologist. Probably to raise my level of Serotonin and “fix” the anxiety. Here’s an article that actually suggests that it could make things worse!

January 13, 2007 Posted by | Health | , , , , , | Leave a comment

Entry for January 13, 2007

I tried another health food store today and went looking for his advice on the different types of garlic. He suggested a supplement called Garlinase but he didn’t have any in stock. I look it up when I get home. It’s supposed to have the highest amount of allicin.

Garlinase 4000 is the only true one-per-day garlic supplement because it’s the only one that equals the German Kommission E daily recommendation of 4,000 mg of fresh garlic with just one tablet. The Kommission E is recognized throughout the world as the model for regulating herbal products. The patented Swiss process used to formulate Garlinase 4000¨ delivers a minimum of 5,000 mcg of beneficial allicin per tablet (the highest potency worldwide). This unique Swiss process also ensures completely odor-free breath. Each box of Garlinase 4000¨ contains a Certificate of Analysis from an independent laboratory documenting the amounts of key compounds found in that batch of tablets.

Found Garlinase in Loblaws but it was $45.00 for 100 capsules!! Expensive, but worth it…if it works. The package said it was to lower cholesterol and mentioned nothing about candida so I’m not taking a chance.

January 13, 2007 Posted by | Health | , | Leave a comment

Entry for January 12, 2007

When I get home I start googling Ps-100 and it turns out that it’s not phosphorus at all! Ps-100 is actually something called phosphatidylserine. And here is what I find out:

Phosphatidylserine

Phosphatidylserine is a vital component of cell membranes and is the major acidic phospholipid in the brain. Its fluid nature, which is necessary for cell to cell communication and cellular metabolism, underscores the importance of this compound in cell membrane function and integrity.

This phospholipid has broad effects in the central nervous system. Administering preparations of phosphatidylserine to aged rats has increased dopamine release in the striatum, stimulated acetylcholine secretion, and has prevented age-related atrophy of cholinergic cells in the basal forebrain. Phosphatidylserine supplementation has demonstrated changes in EEG activity in humans. As well, taking PS over a period of 30 days has restored the circadian rhythmicity of thyroid-stimulating hormone (TSH) secretion in hospitalized patients.

This familiarly-called “brain nutrient” supports cognitive function, emotional well-being and behavioral performance by restoring cell membrane composition. It has also been shown to support memory. In a double blind placebo controlled multicenter study of 425 individuals, daily supplementation of phosphatidylserine over six months resulted in statistically significant support of behavioral and cognitive parameters.

In another six-month study of 40 individuals, phosphatidylserine supplementation enhanced cerebral metabolism and outcomes of cognitive training. These findings are consistent with earlier studies. In a placebo- controlled investigation of 149 subjects, the group receiving phosphatidylserine scored higher than placebo in performance tests related to memory tasks of daily life. In a trial of 35 subjects, those receiving phosphatidylserine exhibited behavioral support after six months. Pure Encapsulations unique formula contains 95-98% phosphatidylserine, the highest concentration available.

Phosphatidylserine may reduce the risk of dementia in the elderly. Very limited and preliminary scientific research suggests that PS may reduce the risk of dementia in the elderly.

Stress

An interesting application of phosphatidylserine is in addressing stress. In a double- blind study of healthy men, phosphatidylserine was administered to half of the participants10 minutes before starting exercise (physically induced stress). [14] The treatment standard was set at administering 50 or 75 milligrams of bovine-cortex phosphatidylserine (BC-PS) intravenously, or oral placebo. The results showed that pretreatment with both 50 and 75mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress.

Another study examined the effect of an oral supplementation of BC-PS on physically induced stress. [15] Healthy subjects took 800mg per day for 10 days. Again, BC-PS significantly blunted the ACTH and cortisol responses to physical exercise without affecting the rise in plasma growth hormone and prolactin.

January 13, 2007 Posted by | Health | , | Leave a comment

Entry for January 12, 2007

While in the health food store I pick up some garlic made by SISU with 2.5 mg of allicin per capsule:

Each caplet contains: Garlic 3:1 extract 250 mg, standardized to contain 2,500 mcg allicin and 5,500 mcg alliin in an enteric coated caplet. No after-odour.

So I’ll need 2 capsules, four times a day to equal eating the cloves. Can you get too much garlic?

SIDE EFFECTS/CONTRAINDICATIONS:

Garlic is extremely safe but taking very large daily doses (more than 10g) of some products may cause flatulence, stomach irritation, or indigestion. Because of garlic’s anti-clotting properties, persons taking anticoagulant drugs, such as Warfarin and Ticlopidine, should check with their doctor before taking garlic. In addition, people scheduled for surgery should inform their surgeon if they are taking garlic supplements Women should avoid taking garlic supplements during pregnancy as laboratory studies suggest that they may cause irregular uterine contractions.

I also pick up some grapefruit seed extract and a candida complex formula. I’m going to throw everything at this candida. I’ve been to this health food store previously and one of the things I noticed is they have a highly recommended magnesium product called Nature Calm so I pick up some of that too because this is the only store where I’ve seen it.

While I’m at the check out, I ask the salesperson if they have a supplement called Phosphorus and she leads me to something called Ps-100 and I take that as well.

Okay candida…you’re finished.

January 13, 2007 Posted by | Health | , , , , | Leave a comment

Entry for January 12, 2007

I’ve been eating so much garlic lately that although it is working really well, there is one side effect: The smell. So I’ll try to track down the best garlic supplement.

I wanted to go to a bigger health food store rather than my usual ones so I make the trip after work to see what I can find. I did a little bit of research during the day and here’s what I found:

Garlic

Garlic has been used for thousands of years for its immune enhancing properties. Modern use of garlic also focuses on its ability to lower cholesterol and blood pressure. Fresh garlic contains 0.1 to 0.36% of a volatile oil composed of the sulfur-containing compounds: alliin, allicin and others. Allicin is the primary compound responsible for the pungent odor of garlic, as well as its pharmacology. Allicin is inactivated by heat, which explains why cooked garlic produces neither as strong an odor as the raw, nor nearly as powerful physiological effects.

Numerous double-blind placebo-controlled studies have been done with standardized commercial preparations that provided a daily dose of at least 10 mg alliin, or a total allicin potential of 4,000 mcg. This is equivalent to 4,000 mg of fresh garlic – roughly one to four cloves. This is the dosage recommended by the German Commission E which establishes dosage requirements to allow for therapeutic claims in Germany. Results show a reduction of 11 mg Hg for systolic and 5.0 mm Hg for diastolic can usually be achieved within a one- to three- month period. Results are significantly better when fresh garlic is used compared to aged garlic.

Daily Nutritional Supplement Consideration:
Standardized commercial preparations that provide a daily dose of at least 10 mg alliin, or a total allicin potential of 4,000 mcg, or 1-4 cloves of fresh garlic a day. In the USA, a standard 500 mg garlic pill of 8,000 ppm allicin potential yields 4,000 mcg of allicin, while a 500 mg garlic pill of 12,000 ppm allicin potential yields 6,000 mcg of allicin.

THERAPEUTIC DAILY AMOUNT:

Garlic is available fresh or juiced, as well as in tablets, capsules, and tinctures. Odor-controlled powders, concentrates, and capsules are popular forms, as are enteric-coated tablets (which have a coating that prevents the destruction of active compounds by stomach acids). Supplement manufacturers are increasingly standardizing their products for desirable garlic compounds (principally one called allicin, but also total sulfur, allin, and S-allyl cysteine), but debate rages on as to which of these compounds are most important and which ormulations are most effective. The potency of garlic products may be described in terms of fresh or whole garlic equivalent; an average dose is 1,500 to 1,800mg of fresh garlic equivalent, approximately equal to eating one-half clove of fresh garlic. To fight infection, 3 or 4 chopped, crushed or chewed cloves should be consumed per day or, in supplement form (1.3% allicin), 600-900 mg divided into 2-3 doses/day.

January 13, 2007 Posted by | Health | , | Leave a comment

   

%d bloggers like this: