Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for December 30, 2006


I’ve been telling my doctor for sometime now that I have some really low vitamin B deficiencies and luckily convinced him to give me a riboflavin injection. I noticed several improvements but he seems hung up on the anxiety diagnosis from the neurologist. Any research on B vitamins suggest that they all work together so if you have one deficiency, you’ll have several and my doctor didn’t seem interested in pursuing it any further.

Found this tonight from who else? Doctor Google:

Anxiety and the Vitamin B complex

Deficiencies of members of the vitamin B complex appear to be common in patients with agoraphobia (fear of open spaces). (1) The same is likely to be true for other anxiety-related conditions. We will review the evidence suggesting that individual members of this family may affect the experience of anxiety.

Inositol Supplementation

Inositol is a key intermediate of the phosphatidyl-inositol cycle, a second-messenger system used by several noradrenergic, serotonergic and cholinergic receptors. Since ingestion has been shown to raise inositol levels in the cerebrospinal fluid, this nutrient could potentially serve as an anti-anxiety agent.

Indeed, when a group of 21 patients with panic disorder either with or without agoraphobia received 12 grams daily of inositol or placebo in random order for 4 weeks each, the inositol supplement was associated with a significantly greater reduction in the frequency and severity of panic attacks and of agoraphobia than the placebo. Moreover, while the efficacy of the nutrient was judged to be comparable to that of imipramine, its side effects were minimal.

Niacinamide Supplementation

Niacinamide has been shown in an animal study to have benzodiazepine-like actions including anti-conflict, anti-aggressive, muscle relaxant and hypnotic effects. In contrast to niacin, it passes readily from the plasma to the cerebrospinal fluid where it is taken up into brain cells by a high-affinity accumulation system, suggesting it is the preferred form of vitamin B3 for the treatment of anxiety.

Lactate (which is associated with anxiety) reacts with niacinamide-adenine dinucleotide [NA[D.sub.+]] to form pyruvic acid and reduced NAD (NADH + [H.sup.+]). The equilibrium of this reaction favors lactate and NA[D.sup.+]), but it can be driven by adding excess NA[D.sup.+]. It may be that supplementation with niacinamide helps to drive the reaction, thus reducing lactate concentrations.

Anecdotal reports suggest that niacinamide has anxiolytic effects comparable to the benzodiazepines, and it may be particularly effective for patients whose anxiety is secondary to reactive hypoglycemia. Typical dosages are between 500 mg twice daily and 1,000 mg 3 times daily. Hoffer believes that the optimal daily dosage is just below the amount that produces nausea.

Thiamine Deficiency

Elevated lactate may also be caused by inadequate pyruvate dehydrogenase activity resulting from a thiamine deficiency or dependency. In that case, the conversion of pyruvate to acetyl CoA is inhibited, fostering its conversion to lactic acid. Symptoms of a prolonged moderate thiamine deficiency may include fearfulness progressing to agitation as well as emotional instability and psychosomatic complaints.

When more than 1,000 healthy young men were studied, those who were chronically borderline thiamine-deficient were currently feeling significantly more anxiety–although they were not customarily nervous individuals. There are no published studies on the repletion of a borderline thiamine deficiency to treat anxiety.

Vitamin B6 Deficiency

Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter which is involved in the regulation of anxiety, requires vitamin B6 for its synthesis; thus a deficiency of this vitamin may theoretically result in heightened anxiety. Vitamin B6 is also required for the conversion of tryptophan to serotonin, a neurotransmitter suspected of being involved in anxiety.

When over 1,000 healthy young men were studied, those found to be chronically deficient in vitamin B6 had a significantly greater tendency to become anxious, although they were not significantly more anxious at the time of the study. Also, in an open trial, patients with hyperventilation syndrome who also had abnormal xanthurenic acid excretion (an indicator of vitamin B6 deficiency) improved following the administration of pyridoxine and tryptophan, suggesting that a marginal B6 deficiency, by causing serotonin depletion, may have produced the syndrome.

Vitamin B12 Deficiency

Anxiety may be part of the neuropsychiatric syndrome seen in advanced cases of pernicious anemia which is well-known to be caused by B12 deficiency. When cobalamin levels of more than 1,000 healthy young men were studied, those who were chronically borderline vitamin B12-deficient were significantly more anxious at the time of the study–although they were not customarily nervous individuals. Whether B12 supplementation reduces anxiety when the vitamin is borderline deficient remains to be investigated.

References

1. Abbey LC. Agoraphobia. J Orthomol Psychiatry 11:243-59, 1982

2. Benjamin J et al. Inositol treatment in psychiatry. Psychopharmacol Bull 31(1):167-75, 1995a

3. Levine J et al. Inositol treatment raises CSF inositol levels. Brain Res 627(1):168-70, 1993

4. Benjamin J et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 15(7):1084-6, 1995b

So I’ve had a blood test for vitamin B12 and Thiamine and both were normal. Still waiting on the results from the vitamin B6 test. I’ve long discovered the Niacin deficiency with some great results but not for anxiety and Inositol I don’t know much about. I believe it’s included in B complex.

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December 30, 2006 - Posted by | Health | , , , , , , ,

1 Comment »

  1. … I’m an aspie and my doctor will NOt give me a vitamin deficiency test. I feel strange around him, he’s nice, but geez. Why cna;t he just DO the test so I can KNOw waht to take? he must think I’m a hypochondriac. wanker.

    ;(

    Comment by tempusdominus10 | September 11, 2012 | Reply


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