Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for September 06, 2006


I’ve known for a while now that magnesium is involved in 300 enzyme reactions within the body. I’m interested in knowing which ones but I can’t seem to find anything that mentions the specific functions. From a muscle building web site, I found another clue:

Magnesium: The Multi-Purpose Mineral

This mineral is involved in over 300 enzymatic reactions in the body including glycolysis, the krebs cycle, creatine phosphate formation, nucleic acid synthesis, amino acid activation, cardiac and smooth muscle contractability, cyclic AMP formation, and most importantly for strength athletes, protein synthesis. Some of the functions of this important macromineral are relevant to endurance and strength athletes. To fully understand the implications this mineral has on athletes, we must explore the roles of magnesium further.

ATP (adenosine triphosphate or energy) is always present as a magnesium: ATP complex. Magnesium basically provides stability to ATP. Magnesium binds to phosphate groups in ATP, thus making a complex that aids in the transfer of ATP phosphate. Since working muscles generally contain more ADP (adenosine diphosphate), allowing ATP to release a phosphate group is important to exercising individuals.

Magnesium is also a cofactor to the enzyme creatine kinase which converts creatine into creatine phosphate or phosphocreatine (which is the storage form of creatine). Since creatine monohydrate supplements are extremely popular and proven to be effective, magnesium may be an important mineral in helping to optimize creatine function. In active muscle, creatine kinase also helps phosphocreatine combine with ADP to resynthesize ATP in contractile activity. This process, which involves magnesium, basically increases anaerobic endurance. By the way, phosphocreatine possesses a higher phosphate group transfer potential than ATP so it may be able to form ATP quickly and provide energy for muscular activity.

Magnesium also plays an important role in protein biosynthesis which is certainly applicable to athletes. It is necessary for the activation of amino acids and the attachment of mRNA to the ribosome. This process helps “make” proteins. In other words, protein synthesis depends on optimal magnesium concentrations. It is hypothesized that low magnesium levels may negatively affect protein metabolism, and may result in diminished strength gains in a structured workout regimen. It is important to note that increasing dietary protein intake may increase magnesium requirements because high protein intake may decrease magnesium retention (5).

To completely understand magnesium function, it is necessary to explore magnesium’s relationship with calcium and potassium. Magnesium is needed for PTH (parathyroid hormone) secretion. PTH helps maintain calcium homeostasis. High magnesium or calcium levels actually inhibit PTH secretion. Magnesium may actually compete with calcium for nonspecific binding sites on myosin. Magnesium may also cause an alteration in calcium distribution by changing the flux of calcium across the cell membrane. It may also decrease intracellular calcium concentrations by inhibiting the release of calcium from the sarcoplasmic reticulum. In the process of blood coagulation, magnesium and calcium are actually antagonistic. Calcium basically promotes this process while magnesium inhibits it. If you take high amounts of calcium daily, you may have a magnesium deficiency. Most experts suggest that your calcium: magnesium ration should be 2:1. In other words, if you take 1500 mg of calcium daily through diet and supplementation, you should try to consume at least 750 mg of magnesium daily as well. this may help prevent an imbalance from occurring. Magnesium and calcium supplements should be taken at different times to allow for better absorption of each of these minerals.

Magnesium and potassium also have a close relationship. Magnesium is necessary for the function of the sodium/potassium pump. If a magnesium deficiency occurs, then pumping sodium out of the cell and pumping potassium into the cell may be impaired. Prescription diuretics tend to deplete magnesium and potassium. In this situation, magnesium intake can normalize both magnesium and potassium levels in the muscle.

Magnesium has also been implicated in the prevention of muscle cramps and muscle spasms. In a clinical study, 500 mg of magnesium gluconate relieved muscle spasms (within a few days) in an adult female tennis player who was complaining about having muscle spasms associated with prolonged outdoor exercise. This may be due to the fact that mineral losses through sweat and urine are increased during prolonged exercise. In specific, sweat losses of magnesium may increase during exercise. Increased loss of magnesium from the body have been seen during and after exercise. A shift in magnesium from the plasma into the erythrocytes was found. Basically , the more anaerobic the exercise (i.e. glycolytic), the greater the movement of magnesium from the plasma into the erythrocytes. This is why athletes may have a greater magnesium requirement.

People who sustain heart attacks are usually magnesium deficient. There are numerous studies which show that magnesium may be very important in cardiac function. For example, one study showed that the early detection of magnesium deficiency is imperative for the prevention of abnormal cardiac metabolism and the maintenance of structural integrity of cardiac muscle during anaesthesia. The best way to get magnesium levels tested by your doctor is to get magnesium levels tested in red blood cells instead of serum. Testing magnesium levels in the serum will detect only the most severe deficiencies.

So what does the research on magnesium with athletes say? One 1992 study published in the Journal of the American College of nutrition entitled “Effect of Magnesium Supplementation on Strength Training in Humans”  studied the effects of a dietary magnesium supplement (magnesium oxide given in a ratio of 8 mg/kg/day including dietary magnesium) on strength development during a double-blind, 7 week strength training program in 26 untrained subjects. There was a magnesium supplemented group and a control or placebo group. For example, a 200 lb. individual in the magnesium supplemented group would receive about 725 mg of magnesium daily. The results of the study showed that the oral magnesium supplementation group produced significantly greater results in strength than the control group. The researchers also concluded that magnesium’s role in protein synthesis may be at the ribosomal level.

Magnesium is also an important mineral for endurance athletes. Endurance athletes may become magnesium deficient because of increased magnesium losses in sweat. Increased energy expenditure may also cause an increase in magnesium requirements. Magnesium supplementation has also been shown to improve cellular metabolism in competitive athletes. Another clinical trial which studied the effects of magnesium supplementation (360 mg/day) for 4 weeks in male competitive rowers showed a decrease in serum lactate concentration and oxygen consumption when compared to rowers receiving a placebo. In other words, the results of this study suggested that magnesium supplementation may have a beneficial effect on energy metabolism and work efficiency.

Other research studies show that serum magnesium levels may be reduced in response to strength training. Also, it has also been noted in research studies that maximal contraction of the quadriceps is positively correlated to serum magnesium status.

Alcoholism, renal disease, diabetes mellitus may all cause a magnesium deficiency to occur. Some of the signs and symptoms of a magnesium deficiency include nausea, vomiting, anorexia, muscle weakness, muscle spasms, and tremors. Poor magnesium status may be related to cardiovascular disease, hypertension, and heart attacks as mentioned earlier. Regular magnesium levels in the red blood cells should be tested for by a doctor every three months to help prevent any deficiency.

Magnesium toxicity is highly unlikely because normal kidneys can remove magnesium extremely rapidly. Toxicity is more likely to occur in individuals who have renal problems. One main effect of excess magnesium intake is diarrhea.

The best forms of supplemental magnesium seem to be the ones chelated to an amino acid (magnesium glycinate, magnesium taurate) or a krebs cycle intermediate (magnesium malate, magnesium citrate, magnesium fumarate). These forms seem to be better utilized, absorbed, and assimilated. Try to stay away from inorganic forms of magnesium like magnesium chloride or magnesium carbonate because they may not be absorbed as well and may cause gastric disturbances.

Dietary fiber impairs magnesium absorption to a small extent so magnesium should not be consumed with any fiber source. Food sources of magnesium include nuts, legumes, and soybeans. Since it may be impractical for athletes to consume enough magnesium through dietary sources, supplemental magnesium may be used. Taking 500-1000 mg/day of magnesium may allow athletes to prevent any deficiencies as well optimize exercise performance.

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September 6, 2006 - Posted by | Health |

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