Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for August 20, 2006


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I feel like I’ve tried every type of magnesium without any real noticeable difference. I’m trying alot of different new things so I thought I’d give it another try. I’ve been reading about this other form a liquid magnesium with high absorption:

Magnesium Gluconate

Benefits of magnesium gluconate: It can be taken on an empty stomach, while the other two forms can cause stomach upset in some people. Magnesium gluconate is absorbed more quickly than other forms. And you don’t have to take quite as much, since the amount of magnesium per capsule that your body can use is higher.

It’s worth a try… I need something with very high absorption and there are so many different types of magnesium. Here’s what I found of the absorption of magnesium:

Pharmacokinetics

The efficiency of absorption of magnesium is inversely proportional to the amount of magnesium ingested. The fractional absorption of magnesium from 7 to 36 milligrams was found to be 65% to 70% in one study. The same study reported a fractional absorption of 11% to 14% with a magnesium intake of 960 to 1,000 milligrams. One study of magnesium absorption from food sources reported a fractional absorption of 40% to 60% of a daily intake of 380 milligrams of magnesium in healthy older men.

Magnesium appears to be absorbed from both the small intestine and the colon. The sites of maximal magnesium absorption appear to be the distal jejunum and ileum. The efficiency of absorption (fractional absorption) of a magnesium salt appears to principally depend on its solubility in intestinal fluids, as well as on the amount digested. Enteric-coated magnesium salts are less efficiently absorbed than non enteric-coated preparations. Salts with high solubility, e.g., magnesium citrate, appear to be more efficiently absorbed than salts with poor solubility, e.g., magnesium oxide.

There are a few reports that suggest that the counter anion of the magnesium salt may influence its absorption. Magnesium aspartate and magnesium orotate are reported by some to be more available forms of magnesium than other magnesium salts. However, there are no compelling data that indicate that the nature of the counter anion makes any significant difference on the availability of magnesium salt, independent of its possible effect on the solubility of the salt.

Magnesium appears to be absorbed by both a saturable active transport mechanism and an unsaturable passive mechanism. The saturable active transport mechanism may account for the higher absorption efficiency at lower magnesium intakes. There is no good evidence that vitamin D and its active metabolite, 1, 25-dihydroxyvitamin D (1, 25(OH)2D) play a significant role in the absorption of magnesium, as some have suggested.

Magnesium is transported to the liver via the portal circulation and to the rest of the body via the systemic circulation. A large fraction of ingested magnesium is taken up by bone. Magnesium transport into cells appears to require the presence of carrier-mediated transport systems. Magnesium is excreted by the kidneys, and the kidney is the principal organ involved in magnesium homeostasis. There is no tubular secretion of magnesium.

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August 20, 2006 - Posted by | Health |

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