Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for August 20, 2006

Here’s an interesting article on the effects of magnesium in the cases of Epilepsy in children. It also talks about how magnesium is found in the spinal fluid and has an effect on balancing the stimulant effect of body hormones on the thyroid and adrenals. Another section talks about how milk depletes magnesium. Both of which have been interesting discoveries of mine in the past month.

EPILEPSY

Wayne was only four years old, but he had been suffering epileptic seizures for 3 1/2 years. Though the seizures were particularly severe during stress periods, he was never completely free of them. Anticonvulsant drugs were used, but none was successful. The boy’s parents were resigned to the probability that he would have a life plagued with severe epilepsy.

At that time Dr. Lewis B. Barnett, head of the Hereford Clinic and Deaf Smith Research Foundation in Hereford, Texas, began a series of experiments. The boy became a subject. He was given, in addition to a normal diet, 450 mg. of magnesium gluconate and a thyroid extract. Within two weeks all signs of epilepsy vanished, and within the past three years there have been no signs of the illness.

Is It Magnesium Deficiency?

In 28 more cases, the same story has been repeated. Children of all ages, stricken with epilepsy failed to respond or responded only slightly to modern drugs and therapy. Placed on high oral doses of magnesium, they experienced stunning improvement.

Barnett did not start out to investigate a relationship between magnesium and epilepsy. He says, “My original work was directed toward the role of magnesium in bone apatite, and while investigating that field, it became obvious that magnesium might play a vital role in the physiology of the central nervous system.” He studied the relatively few reports in medical literature concerned with the mineral, and found one by Martin, Meke, and Wertman. These researchers reported that in a state of epilepsy there is a deficiency of magnesium in the blood.

Children who definitely suffered from epilepsy were used in the Hereford study. First, their blood magnesium levels were established. In all cases, the levels were below normal, supporting the findings of Martin, Meke, and Wertman. Next Barnett decided to correct the deficiency by giving oral magnesium preparations. “It was hoped that the magnesium supplement would control the seizures,” he told us in an interview.

Within a matter of weeks the blood magnesium level returned to normal, and in every case, except one there was definite clinical improvement.

“After reviewing most of the literature,” Mr. Barnett says, “not very extensive according to references, it became obvious to me that very little work had been done in this most important and extremely active mineral–especially in its relation to the physiology of the central nervous system.”

In his experiments, Barnett used magnesium gluconate, a form of magnesium which is easily absorbed by the system. ‘Taken orally in this form, magnesium is harmless in almost any quantity,” he reports. “The worst that can occur is that some individuals will become drowsy.”

This tendency toward causing drowsiness is one of the key properties of the mineral.

Spine Concentrates Magnesium

It has been known for many years that magnesium is an analgesic. It is found both in the blood and in the spinal fluid, and is the only electrolyte found in higher concentration in the spinal fluid than in the blood. This is an important fact for two reasons:

First, testing for a deficiency of magnesium in the spinal fluid is easily done by taking a blood test and deciding what the magnesium level in the blood is. Scientists have found that the lower the blood level, the lower the spinal fluid level.

Second, the reason for the high magnesium content in the spinal fluid is that the mineral is necessary for balancing the stimulant effect of body hormones. The purpose of thyroid, gonadal, adrenal and other hormones is to charge up or excite the body. Magnesium and some other substances tend to slow down and relax the system, thus regulating the hormones and achieving a happy medium.

When magnesium deficiencies occur–and there are a number of reasons why this can happen–there is no regulation. Among the dangerous results of this state listed in medical literature are heart damage, osteoporosis, periodontal disease, and epilepsy. Another is hyperirritability. “A great many people have a magnesium deficiency manifesting itself in hyperirritability,” Barnett said. These people may often have a metabolic rate 125 percent higher than normal, he says.

Their bodies and minds are greatly overactive, and they are constantly irritated. This is undoubtedly a partial explanation for the high rate of juvenile delinquency, divorce, and emotional instability rampant in modem society. 

Pituitary Gland Important

A magnesium deficiency, according to Barnett, is a prime cause of the three million clinical and 10 to 15 million subclinical epilepsy cases now in this country. Deficiency may occur not from a lack of magnesium in the diet but because of malfunctioning of the pituitary gland. As far back as 1952, researchers observed that people suffering a magnesium deficiency had reactions similar to those in people who had had the Pituitary gland removed. The reason for this is not hard to understand.

The pituitary gland, located at the base of the brain, is believed, to regulate the functions of all the other glands of the body. It is the gland through which magnesium works as a prime component of pituitary secretions to regulate the functioning of the other glands. If magnesium is not available or the pituitary is not functioning properly, the body will suffer symptoms of a magnesium deficiency or a pituitary malfunction, depending on how you look at it. (It must also be pointed out that fluoride bonds with magnesium in the blood, into the insoluble magnesium fluoride. This means that the magnesium cannot be assimilated by the pituitary, with the consequent failure of the pituitary to function properly that leads to the symptoms of magnesium deficiency.)  

Milk Depletes Magnesium

The first step in treating the symptoms of magnesium depletion, especially among children, is to eliminate milk from the diet, according to Dr. Barnett. He reports that nine out of ten childhood epileptics drink milk. Calciferol (synthetic vitamin D), Re fluorine, tends to bind the magnesium, be says. Milk is loaded with this substance and therefore enhances the problem. The synthetic form of the vitamin is 10 times more active than the natural form–which means it is 10 times more potent in binding magnesium. For this reason the natural vitamin, as found in fish liver oils, will not cause magnesium depletion, but milk can and does.

The second step, though new to medicine, is “old hat’ to ranchers. Green grass tetany, the cattle equivalent of human hyperirritability, costs ranchers about a half billion dollars a year. This problem can be effectively treated only by adding magnesium to the animal’s diet, but this must be done before the disease reaches serious proportions.

According to Barnett, this same therapy is often effective in humans. He considers dolomitic limestone an excellent form of the mineral.

Although compared to the early days of Barnett’s research there have recently been many studies done on magnesium, its relation to epilepsy treatment has been largely ignored. Barnett hopes that now his studies will lead to other clinical experiments, and that eventually doctors will be able to control many cases of epilepsy without using depressant drugs. “By balancing their physiological state, with special emphasis on intracellular chemistry, an easier and finer control of these unfortunate individuals may be possible,” he said.

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August 20, 2006 Posted by | Health | , , , | Leave a comment

Entry for August 20, 2006

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I feel like I’ve tried every type of magnesium without any real noticeable difference. I’m trying alot of different new things so I thought I’d give it another try. I’ve been reading about this other form a liquid magnesium with high absorption:

Magnesium Gluconate

Benefits of magnesium gluconate: It can be taken on an empty stomach, while the other two forms can cause stomach upset in some people. Magnesium gluconate is absorbed more quickly than other forms. And you don’t have to take quite as much, since the amount of magnesium per capsule that your body can use is higher.

It’s worth a try… I need something with very high absorption and there are so many different types of magnesium. Here’s what I found of the absorption of magnesium:

Pharmacokinetics

The efficiency of absorption of magnesium is inversely proportional to the amount of magnesium ingested. The fractional absorption of magnesium from 7 to 36 milligrams was found to be 65% to 70% in one study. The same study reported a fractional absorption of 11% to 14% with a magnesium intake of 960 to 1,000 milligrams. One study of magnesium absorption from food sources reported a fractional absorption of 40% to 60% of a daily intake of 380 milligrams of magnesium in healthy older men.

Magnesium appears to be absorbed from both the small intestine and the colon. The sites of maximal magnesium absorption appear to be the distal jejunum and ileum. The efficiency of absorption (fractional absorption) of a magnesium salt appears to principally depend on its solubility in intestinal fluids, as well as on the amount digested. Enteric-coated magnesium salts are less efficiently absorbed than non enteric-coated preparations. Salts with high solubility, e.g., magnesium citrate, appear to be more efficiently absorbed than salts with poor solubility, e.g., magnesium oxide.

There are a few reports that suggest that the counter anion of the magnesium salt may influence its absorption. Magnesium aspartate and magnesium orotate are reported by some to be more available forms of magnesium than other magnesium salts. However, there are no compelling data that indicate that the nature of the counter anion makes any significant difference on the availability of magnesium salt, independent of its possible effect on the solubility of the salt.

Magnesium appears to be absorbed by both a saturable active transport mechanism and an unsaturable passive mechanism. The saturable active transport mechanism may account for the higher absorption efficiency at lower magnesium intakes. There is no good evidence that vitamin D and its active metabolite, 1, 25-dihydroxyvitamin D (1, 25(OH)2D) play a significant role in the absorption of magnesium, as some have suggested.

Magnesium is transported to the liver via the portal circulation and to the rest of the body via the systemic circulation. A large fraction of ingested magnesium is taken up by bone. Magnesium transport into cells appears to require the presence of carrier-mediated transport systems. Magnesium is excreted by the kidneys, and the kidney is the principal organ involved in magnesium homeostasis. There is no tubular secretion of magnesium.

August 20, 2006 Posted by | Health | | Leave a comment

Entry for August 20, 2006

According to this web site, injectable magnesium is available by prescription. I asked the pharmacist a few days ago and he said he had nothing. This web site says it’s available in Canada…

Magnesium Supplements (Systemic) – Mayo Clinic Medical Services

Canadian Brand Names
        Citro-Mag
        Mag
        Maglucate
        Magnesium-Rougier
        Phillips’ Magnesia Tablets
        Phillips’ Milk of Magnesia

Description

Magnesium is used as a dietary supplement for individuals who are deficient in magnesium. Although a balanced diet usually supplies all the magnesium a person needs, magnesium supplements may be needed by patients who have lost magnesium because of illness or treatment with certain medicines. Lack of magnesium may lead to irritability, muscle weakness, and irregular heartbeat.

Injectable magnesium is given only by or under the supervision of a health care professional. Some oral magnesium preparations are available only with a prescription. Others are available without a prescription.

Magnesium supplements are available in the following dosage forms:

Oral

  Magnesium Chloride
    Tablets (U.S.)
    Enteric-coated tablets (U.S.)
    Extended-release tablets (U.S.)
  Magnesium Citrate
    Oral solution (U.S. and Canada)
  Magnesium Gluceptate
    Oral solution (Canada)
  Magnesium Gluconate
    Oral solution (U.S.)
    Tablets (U.S. and Canada)
  Magnesium Hydroxide
    Tablets (U.S.)
    Chewable tablets (U.S. and Canada)
    Oral solution (U.S. and Canada)
  Magnesium Lactate
    Extended-release tablets (U.S.)
  Magnesium Oxide
    Capsules (U.S.)
    Tablets (U.S. and Canada)
  Magnesium Pidolate
    Powder for oral solution (Canada)
  Magnesium Sulfate
    Crystals (U.S.)
  Parenteral
  Magnesium Chloride
    Injection (U.S.)
  Magnesium Sulfate
    Injection (U.S. and Canada)

For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional
for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.

The best dietary sources of magnesium include green leafy vegetables, nuts, peas, beans, and cereal grains in which the germ or outer layers have not been removed. Hard water has been found to contain more magnesium than soft water. A diet high in fat may cause less magnesium to be absorbed. Cooking may decrease the magnesium content of food.

August 20, 2006 Posted by | Health | | Leave a comment

Entry for August 20, 2006

When I spoke to the pharmacist next to the osteopath, he seemed to think my problems were related to thyroid and the production of something called T4. He went on to explain how doctor’s usually test for the one level of but the not the level that is required to activate it. My low body temperature test is a way of testing the thyroid so whatever it is that is effecting me, is also effecting the thyroid.

And found this today:

Thyroid disorders- low, high and auto-immune; low magnesium reduces T4.

And this on Boron:

BORON

Very little research has been done on boron and little is known about the symptoms of boron deficiency. Following we piece together a picture that indicates that boron is essential for magnesium and calcium metabolism, and is probably involved in estrogen and testosterone metabolism. There are a lot of reasons to suspect that a boron deficiency is involved in hyperthyroidism.

The following study suggests that boron works with magnesium and this may be one reason that it benefits persons with hyperthyroidism or persons with thyroid disease who are experiencing low magnesium symptoms like rapid heart rate and muscle cramping. You will note that boron both lessens the effects of a low magnesium diet but exacerbates deficiency symptoms. These seem to be the typical characteristics of when one nutrient works with another. Boron thus seems essential for magnesium metabolism and administration of boron will lower magnesium levels because it is enabling more of the magnesium to be utilized.

Another interesting observation in this study is that fructose mimics a magnesium deficiency, which reminds me of the studies on copper deficiency which showed that the symptoms of copper-deficiency are worse if the animal is also consuming fructose. We have seen that hypers have increased symptoms after eating fruit and this effect may be due to fructose increasing copper-deficiency symptoms. It would be very interesting to know how this fructose effect works–perhaps not by increasing copper deficiency itself but because it works like copper-deficiency in increasing the magnesium deficiency effects.

MAGNESIUM

Because of the competing nature of calcium and magnesium, excessive calcium intake from foods or supplements can lead to a magnesium deficiency. The symptoms of magnesium deficiency are identical with many of the symptoms of thyroid disease, especially hyperthyroidism.

Functions: 

The principal function of magnesium that is critical in thyroid disease is that it enables muscles to relax. With inadequate magnesium, the muscles cramp. When this happens to the heart muscles the heart does not go through a complete relaxation phase, and the next calcium-driven contraction begins before the relaxation is complete. This results in rapid heart beat and irregular heart rate known as arrhythmia.

August 20, 2006 Posted by | Health | , , | Leave a comment

Entry for August 20, 2006

Woke up with a slight vibration…

For the past little while I was taking two capsules between meals. One capsule of magnesium taurate and one capsule of magnesium citrate. I ran out of magnesium citrate yesterday so now I’m only taking magnesium taurate.

Last Sunday when the magnesium had the greatest effect on my energy level, I took two capsules of magnesium citrate. I don’t seem to be getting the same effect from taking the magnesium taurate.

August 20, 2006 Posted by | Health | , | Leave a comment

Entry for August 19, 2006

I went into Shoppers Drug Mart today for some magnesium epsom salts. Out of curiosity, I ask the pharmacist if there is a magnesium supplement available only by prescription. He checks the computer and he says there is only the stuff that available over the counter. No thanks…

I wasn’t hungry at dinner so I didn’t eat until later and I had a can of tuna just before going to bed. Tuna is considered protein so let’s see if it makes a difference with the magnesium. I take two capsules of magnesium taurate and it’s off to bed and there is no vibration.

August 20, 2006 Posted by | Health | , , | Leave a comment

   

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