Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for August 14, 2006

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Magnesium Balance

Magnesium is the fourth most common mineral in a living organism, and 65 percent of it is bound in the skeleton. The body can mobilize only 25 percent of this “bone magnesium” in situations of extreme deficiency. This capacity also diminishes as age increases.

The other 34 percent of the body’s magnesium is found in the muscles and other organs in various concentrations (see Table 1). Only 1 percent of the body’s entire magnesium is extracellular, and serum magnesium represents only 0.3 percent.

The free Mg(2+) ions are the physiologically active component of the extracellular magnesium, which has the highest turnover rate of all magnesium fractions. An important role in regulating magnesium balance is played by absorption in the gastrointestinal tract and by the excretion via the kidneys.

Nerve and Muscle Relaxation

Magnesium and its fellow macronutrient, calcium, act together to help regulate the body’s nerve and muscle tone. In many nerve cells, magnesium serves as a chemical gate blocker – as long as there is enough magnesium around, calcium can’t rush into the nerve cell and activate the nerve. This gate blocking by magnesium helps keep the nerve relaxed. If our diet provides us with too little magnesium, this gate blocking can fail and the nerve cell can become overactivated. When some nerve cells are overactivated, they can send too many messages to the muscles and cause the muscles to overcontract. This chain of events helps explain how magnesium deficiency can trigger muscle tension, muscle soreness, muscle spasms, muscle cramps, and muscle fatigue.

So the heart, muscles, kidney, liver, brain, lungs, spleen and stomach are all effected by magnesium. It’s no wonder that there are so many symptoms related to a deficiency.

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August 14, 2006 Posted by | Health | , | Leave a comment

Entry for August 14, 2006

I start the day organizing the myelin sheath building vitamins. B1, B6, B12, folate, vitamin C, D, and E, Magnesium, Omega 3 and Lecithin.

Here’s what I find on magnesium absorption:

Best taken: At bedtime with calcium in the ratio of one or two parts calcium to one part magnesium. Most absorbable forms are magnesium orotate and amino-chelated magnesium. Magnesium gluconate and magnesium chloride are less effective but can be taken orally.

The process of digestion and absorption of magnesium is very similar to that of calcium. The suggested ratio of intake of these two vital nutrients is about 2:1, calcium to magnesium. Magnesium also requires an acidic stomach environment for best absorption, so taking it between meals or at bedtime is recommended. Meals high in protein or fat, a diet high in phosphorus or calcium (calcium and magnesium can compete), or alcohol use may decrease magnesium absorption.

Usually, about 40-50 percent of the magnesium we consume is absorbed, though this may vary from 25-75 percent depending on stomach acid levels, body needs, and dietary habits.

The levels of magnesium used by physicians are commonly in the range of 600-1,000 mg.; however, the researchers in the kidney stone studies used only 200-300 mg. of supplemental magnesium oxide. Calcium and magnesium are both alkaline minerals, so they are not taken with or after meals, as they can reduce stomach acid as well as being absorbed poorly when taken with food. They are absorbed better when taken between meals or on an empty stomach, especially with a little vitamin C as ascorbic acid.

Many calcium-magnesium combinations are formulated with hydrochloric acid and vitamin D to aid the mineral absorption. And taking them before bedtime may be very helpful in increasing utilization of both these important minerals and lead to a sleep-filled night.

The best forms of supplemental magnesium seem to be the ones chelated to an amino acid (magnesium glycinate, magnesium taurate) or a krebs cycle intermediate (magnesium malate, magnesium citrate, magnesium fumarate). These forms seem to be better utilized, absorbed, and assimilated. Try to stay away from inorganic forms of magnesium like magnesium chloride or magnesium carbonate because they may not be absorbed as well and may cause gastric disturbances.

The magnitude of increased absorption with true amino acid chelates is biologically profound. Comparing a magnesium amino acid chelate to magnesium oxide (a typical salt found in many supplements) the amino acid chelate had 9 times the absorption as the oxide. This study compared the use of the single mineral. If another inorganic mineral were given at the same time, such as calcium carbonate, the usual effect would be no reduction of the amino acid chelate, but a further 70-80% reduction of magnesium absorption from the oxide form. The net effect on absorption of chelated to inorganic magnesium, if two or more inorganic minerals are taken, can be 20-30 fold greater absorption or more of the amino acid chelate.

Magnesium-containing products are either used in treating a primary or secondary magnesium deficiency or are given for prophylaxis as food supplement. Various inorganic (oxides, chlorides, sulfates and carbonates) and organic (citrates, aspartates) magnesium compounds are available for oral administration.

A comparison of the magnesium content of food as stated in tables of nutritional values and the actual analytical values showed that food contains less magnesium than reported in the literature. This means that a deficiency may arise even when the calculated intake is sufficient. Also, food processing, such as polishing rice or cooking fresh vegetables, can lead to loss of magnesium. However, insufficient supply due to nutrition is only one of many causes of magnesium deficiency.

Those suffering from chronic fatigue syndrome also seem to do better with magnesium given by injection. This may be due to the superior absorption of injectable magnesium or because high concentrations in the body are necessary for maximal therapeutic effects.

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Entry for August 14, 2006

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After today, I’m starting to feel more and more like Augusto in Lorenzo’s oil.

What a great movie. I recommend it for anyone who has doubts about the medical profession and takes on their own research with a commitment to greater health.

No vibration last night and none again this morning…

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Entry for August 14, 2006

And this:

It is now known the cause for the destruction of the myelin in the lesions is overactivation of the microglia in the region of the myelin. An enzyme that converts glutamine to glutamate called glutaminase increases tremendously, thereby greatly increasing excitotoxicity. Mercury also activates microglia, even in subtoxic doses.
 
Any dietary excitotoxin can activate the microglia, thereby greatly aggravating the injury. This includes the aspartate in aspartame. The methanol adds to this toxicity as well. Now, the secret to treatment appears to be shutting down, or at least calming down, the microglia. It has been found that the antibiotic minocycline powerfully shuts down the microglia. I tried this treatment on a friend of mine who just came down with fulmanant MS. He was confined to a wheelchair. I had him placed on minocycline and now, just a few weeks later, he is walking.
 
The good news is that other things also calm the microglia-the most potent are: silymarin, curcumin and ibuprophen. Phosphatidylcholine helps re-myelinate the nerve sheaths that are damaged, as does B12, B6, B1, vitamin D, folate, vitamin C, natural vitamin E (mixed tocopherols) and L-carnitine. DHA plays a major role in repairing the myelin sheath. Vitamin D may even prevent MS, but it acts as an immune modulator, preventing further damage – the dose is 2000 IU a day. Magnesium, as magnesium malate, is needed in a dose of 500 mg 2X a day. They must avoid all excitotoxins, even natural ones in foods-such as soy, red meats, nuts, mushrooms and tomatoes. Avoid all fluoride and especially all vaccinations since these either inhibit antioxidant enzymes or triggers harmful immune reactions.

Phosphatidylcholine helps re-myelinate the nerve sheaths. What is this stuff and how can I get me some?

Phosphatidylcholine is a phospholipid that is a major constituent of cell membranes. Phosphatidylcholine is also known as 1, 2-diacyl-:ussn:ue-glycero-3-phosphocholine, PtdCho and lecithin.

So Phosphatidylcholine, is a fancy name for lecithin. Perfect! I already have some. Interestingly enough, three of the main supplements that are required for rebuilding the myelin sheath, the iridologist told me I didn’t need them:

Magnesium, Vitamin D and DHA from Omega 3.

More about Magnesium Malate:

Heavy Metal Toxicity

Magnesium malate may be one of the few compounds capable of pulling aluminum from the body over time.

And my hair analysis came up with high aluminum levels and this form of magnesium is recommened for building the myelin sheaths and removing aluminum from the body. The Naturopath didn’t mention this? She gave me a standard calcium/magnesium but I’m sure it wasn’t magnesium malate.

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Entry for August 14, 2006

More googling turned up this:

Ultrastructure of the optic nerve in magnesium-deficient rats.

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

PURPOSE: The ultrastructure of the optic nerves in magnesium (Mg)-deficient rats was studied to elucidate the function of Mg.

METHODS: After delivery, mother Wistar Kyoto rats were fed a low-Mg diet containing 0.1 mg Mg/100 g diet with all other nutrients and distilled and deionized water. Infant rats were suckled by their mothers for 21 days and then fed the same Mg-deficient diet. Control mother rats were fed commercial rat pellets containing 24 mg Mg/100 g diet and all other nutrients. The optic nerves were examined by electron microscopy at 6 weeks of age.

RESULTS: In the Mg-deficient rats, serum Mg levels were significantly lower and calcium levels higher than in the control rats. Ultrastructural findings were: significantly fewer myelinated axons and significantly thinner myelin sheaths in the Mg-deficient rats than in the control and pair-fed controls, and more numerous unmyelinated axons. There were multifocal areas of destruction and necrosis in the optic nerve of Mg-deficient rats.

CONCLUSIONS: This study suggests that the optic nerve needs Mg for the development and maintenance of its cell structure.

Copyright 2003 S. Karger AG, Basel

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Entry for August 13, 2006

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In my research, I come across a site that talks about the effects of magnesium. A friend of mine has recently had ringing in her ears and she’s been going to a bunch of specialists and just last week diagnosed with vertigo. She said it appeared after she started a big project so it could be stress related. In fact, it’s so so bad that she can’t drive her car to work.

Magnesium deficient symptoms? Tinnitus and Vertigo. I’ll mention this to her when I see her next and tell her about the absorption rates for magnesium taurate.

The irony? She was the one who suggested that I use google for my symptoms way back when it first started…

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Entry for August 13, 2006

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By the afternoon I think even my wife if amazed at the amount of energy I have. I want to go back to the first health food store and see if they have magnesium taurate. I put our daughter in the stoller and we walk to the store a couple of blocks from our house. I have never done this before and I think it’s a clear indication of how great I felt and how much energy I had.

Into the store and they have magnesium taurate on the top shelf so I pick some up. I have enough magnesium now to last me a lifetime but it will be interesting to see which one works best.

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Entry for August 13, 2006

I’m looking for better absorption so I want something with magnesium glycinate, magnesium aspartate or magnesium taurate. Any one of those will do.

The health food store I wanted to try wasn’t open until noon. By the third health food store, I’m having no luck finding magnesium taurate but the salesperson was very talkative and knowledgeable. I explain that I’m looking for magnesium with a high absorption rate. She shows me a supplement that contains magnesium glycinate but it also contains calcium. (I’ve read that if you have a magnesium deficiency you shouldn’t take calcium at the same time.)

Then she shows me an absorption chart. I don’t remember it exactly but oxide was at the bottom, citrate was around 33% and glycinate was 67%. I can double my absorption rate and I am sold!

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Entry for August 13, 2006

Went back to my normal vitamins and by noon I feel great with a lot more energy. The only real difference? I took 300 mg of magnesium citrate. I hit google looking for some tips for better absorbtion.

Symptoms of Magnesium Deficiency?

Symptoms involving impaired contraction of smooth muscles include constipation; urinary spasms; menstrual cramps; difficulty swallowing or a lump in the throat-especially provoked by eating sugar; photophobia, especially difficulty adjusting to oncoming bright headlights in the absence of eye disease; and loud noise sensitivity from stapedius muscle tension in the ear.

Other symptoms and signs of magnesium deficiency and discuss laboratory testing for this common condition. Continuing with the symptoms of magnesium deficiency, the central nervous system is markedly affected. Symptoms include insomnia, anxiety, hyperactivity and restlessness with constant movement, panic attacks, agoraphobia, and premenstrual irritability. Magnesium deficiency symptoms involving the peripheral nervous system include numbness, tingling, and other abnormal sensations, such as zips, zaps and vibratory sensations.

Prevention and Treatment of Magnesium Deficiency Using Oral and Injectable Magnesium

For people who suffer from chronic magnesium deficiency and also to prevent the development of this condition, oral magnesium supplements can be quite useful. Magnesium is available in many forms. The cheapest is probably magnesium oxide, but this form is not absorbed as well as some other forms, which include chelated magnesium, magnesium glycinate and magnesium aspartate. Dr. Baker feels that the prescription form of magnesium chloride, known as Slow-mag, has been most useful for his patients.

I have found that magnesium taurate, an unusual form of magnesium in which magnesium is chemically combined with the amino acid derivative taurine, is particularly well utilized and beneficial. This is because some of the same effects that one hopes to get from magnesium, such as the calming effect on the nervous system, and the strengthening effect on heart muscle, is also gotten with taurine. So, the two are synergistic together. I use it in all forms of cardiac and nervous system disorders.

What about dosage? The recommended daily allowance or RDA for magnesium is 350 milligrams of elemental magnesium. An important point here is that when reading the label of a supplement containing magnesium, it is important to distinguish between the number of milligrams per tablet or capsule of the entire magnesium complex versus the number of milligrams of elemental magnesium or pure magnesium. For example, one label of a chelated magnesium states that 4 tablets contain 4,000 mg of the chelated magnesium complex with 500 mg of elemental magnesium. The important number is the one that refers to the elemental magnesium. The other 3,500 mg in this case refers to the amino acid complex that is bound to the magnesium.

Keeping this definition of elemental magnesium in mind, many people do not even get the RDA of 350 mg of magnesium daily. A therapeutic dosage could easily run between 400 mg and 1000 mg daily of elemental magnesium in divided doses. In people with normal kidneys, it is difficult to reach toxic levels of magnesium. However, too much oral magnesium will result in diarrhea. Recall that milk of magnesia is a laxative containing a magnesium salt. Patients suffering from chronic kidney failure must be much more careful because their kidneys have difficulty eliminating magnesium and a toxic buildup may occur. Toxic levels of magnesium may lead to depression of the entire nervous system and even coma and death. But, this is extraordinarily rare and occurs only in patients with severe kidney function impairment. In general, magnesium doses of 1000 mg per day or less are extremely safe.

If this form of magnesium taurate has a calming effect on the nervous system and best absorption, then I’m off to see if I can get some.

Magnesium taurate at dosages of 250 to 500 mg., if well tolerated (no diarrhea) by the intestines, is better absorbed than any other oral tablet or capsule. This approach requires 6 to 12 months.

There is virtually no illness, which is not helped significantly by magnesium.

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Entry for August 13, 2006

Last night I had the vibration again but it seems to come and go. This morning however, I had a very strong vibration and it hasn’t felt like this in a very long time. What caused it to be so strong?

Back to my daily routine of vitamins…

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Entry for August 12, 2006

Went to the Chiropractor this morning. The same kind of stretching and he offers a bunch of ideas again. He told me to look up something called immunol, beta glucan and celiac sprue. I did a quick search on those but nothing interesting really came up.

I’ve felt lousy all day with zero energy. Probably the worst I’ve felt in a long time. By mid afternoon I take a hot bath as that will always make me feel better and it does. Why do I have no energy? I’m still taking the B complex vitamins and now the omega 3 so there must be something else.

The riboflavin injection seems to have no effect. The only symptom I haven’t had is the tingling of the myelin sheaths. So maybe my problem is from a number of deficiencies instead of just one.

I keep trying to look for the one thing that is causing my symptoms. Maybe it’s possible there is a combination of deficiencies.

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