Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for July 11, 2006


For three days in row now I’ve had no vibration at night but I have it when I wake up. I am now starting to suspect that it’s linked to a Vitamin D deficiency.

So here we go again…

Vitamin D Deficiency

In vitamin D deficiency, calcium absorption cannot be increased enough to satisfy the bodys calcium needs. Consequently, PTH production by the parathyroid glands is increased and calcium is mobilized from the skeleton to maintain normal serum calcium levels a condition known as secondary hyperparathyroidism. Although it has long been known that severe vitamin D deficiency has serious consequences for bone health, recent research suggests that less obvious states of vitamin D deficiency are common and increase the risk of osteoporosis and other health problems.

Importance

Very important in infancy and childhood; healthy bone formation; healthy nervous system maintenance; good for thyroid gland, skin, teeth, normal blood clotting.

Enhances Absorption

Phosphorus, calcium, choline and vitamins A, C, F.

Vitamin D is vital to the human body as it promotes absorption of calcium and magnesium, which are essential for the normal development of healthy teeth and bones. It also helps maintain adequate levels of calcium and phosphorus in the blood.

Muscle Weakness and Pain

Vitamin D deficiency causes muscle weakness and pain in children and adults. Muscle pain and weakness was a prominent symptom of vitamin D deficiency in a study of Arab and Danish Moslem women living in Denmark. In a cross-sectional study of 150 consecutive patients referred to a clinic in Minnesota for the evaluation of persistent, nonspecific musculoskeletal pain, 93% had serum 25(OH)D levels indicative of vitamin D deficiency. A randomized controlled trial found that supplementation of elderly women with 800 IU/day of vitamin D and 1,200 mg/day of calcium for three months increased muscle strength and decreased the risk of falling by almost 50% compared to supplementation with calcium alone.

Hypertension (High Blood Pressure)

The results of epidemiological and clinical studies suggest an inverse relationship between serum 1,25(OH)2D levels and blood pressure, which may be explained by recent findings that 1,25(OH)2D decreases the expression of the gene encoding renin (see Function). Data from epidemiological studies suggest that conditions that decrease vitamin D synthesis in the skin, such as having dark skin and living in temperate latitudes, are associated with increased prevalence of hypertension. A controlled clinical trial in 18 hypertensive men and women living in the Netherlands found that exposure to UVB radiation three times weekly for six weeks during the winter increased serum 25(OH)D levels and significantly decreased 24-hour ambulatory systolic and diastolic blood pressure measurements by an average of 6 mm Hg. In randomized controlled trials of vitamin D supplementation, a combination of 1,600 IU/day of vitamin D and 800 mg/day of calcium for eight weeks significantly decreased systolic blood pressure in elderly women by 9% compared to calcium alone, but supplementation with 400 IU/day or a single dose of 100,000 IU of vitamin D did not significantly lower blood pressure in elderly men and women over the next two months. At present, data from controlled clinical trials are too limited to determine whether vitamin D supplementation will be effective in lowering blood pressure or preventing hypertension.

Tolerable Upper Intake Level

Adults 19 years and older 50 mcg (2000 IU)

So vitamin D is used in the aborption of calcium and magnesium. Could this be why there has been no improvement despite taking a calcium/magnesium suppliment? Interestingly with the success I’ve had in the past three days, I’ve managed to increase my calcium, magnesium and added vitamin D to my daily intake. Coincidence?

Calcium Balance

Maintenance of serum calcium levels within a narrow range is vital for normal functioning of the nervous system, as well as for bone growth, and maintenance of bone density. Vitamin D is essential for the efficient utilization of calcium by the body. The parathyroid glands sense serum calcium levels, and secrete parathyroid hormone (PTH) if calcium levels drop too low. Elevations in PTH increase the activity of 25(OH)D3-1-hydroxylase enzyme in the kidney, resulting in increased production of 1,25(OH)2D. Increasing 1,25(OH)2D production results in changes in gene expression that normalize serum calcium by

1) Increasing the intestinal absorption of dietary calcium.

2) Increasing the reabsorption of calcium filtered by the kidneys.

3) Mobilizing calcium from bone when there is insufficient dietary calcium to maintain normal serum calcium levels. Parathyroid hormone and 1,25(OH)2D are required for the latter two effects.

And with that. I’ll increase my vitamin D to 2000 IU per day. It will be interesting to see if that makes a difference on the morning vibration.

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July 11, 2006 - Posted by | Health | , , ,

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