Diary of Unknown Symptoms

Mystery of the Internal Vibration

Entry for June 21, 2006


Back to researching B vitamins. You’d think with everything that I have read so far, I’d be an expert. Then Doctor Google comes up with this gem. Ok, I don’t have HIV or AIDS, but the article talks about B vitamin deficiencies and how Thiamine is used in treating diabetic neuropathy.


Stanley Mirski, M.D., has reported that a large percentage of his diabetic patients who suffer from neuropathy have achieved improvements with daily thiamine supplementation in doses of 50-100 mg. Using a fat-soluble form of thiamine such as thiamine tetrahydro-furfuryl disulfide may be preferable because of the relatively poor absorption of water-soluble forms of this vitamin. This type is contained in Cardiovascular Research’s Allithiamine. A large number of HIV-positive people have reported to me their successful elimination of neuropathy with the combined use of the B vitamins discussed here. The information on acetyl-l- carnitine is too recent for much in the way of anecdotal reports to have surfaced, but it might be an important addition to improve the chances for successful elimination of neuropathy. Research has made it clear that people living with HIV are often deficient in carnitine.

WHAT!!!! There is a fat-soluble form of thiamine???!!!! I pull up the web site for the local health food store down the street and I type “thiamine tetrahydro-furfuryl disulfide” into the search engine and nothing comes up. So I search “thiamine” alone and get two results. I click on the second result because it says B1 and it’s the suppliment I already have. I click on the second one and it’s called Benfotiamine. I’ve never heard of it and they provide a link to the manufacturer’s web site. I click on that and I read about how it raises the level of thiamine in the blood. NOW THAT’S WHAT I NEED!!! And it was about three blocks away from my house the entire time.

Benfotiamine for Neuropathy, Retinopathy, and Vitamin B1 deficiency

Recent studies have shown strong evidence pointing to benfotiamine preventing and helping diabetic neuropathy and retinopathy.. The original patent on benfotiamine gave information that it is even less toxic than common vitamin B1 (thiamine hydrochloride usually).. To date, there has been no reports of any known, negative interactions with any medications.. Any condition that is the result of a thiamine deficiency will respond quite well to benfotiamine.


Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.

Thiamine and its Co-enzyme, TPP

Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name “thiamine diphosphate.” In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as “active acetate.” Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called “oxidative decarboxylation” and for this reason, TPP was originally referred to as “cocarboxylase.” TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical “super-thiamin” it does this through several different cellular mechanisms, as discussed below.

Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose. To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.

Found another web site that talks about the treatment using this suppliment.


Though the body cannot use more than about 10mg of common, water-soluble vitamin B-1 per day, benfotiamine is lipid-soluble and can safely be used at much higher levels than common vitamin B-1.

Most people get excellent results in 14-21 days time using two 150mg. Capsules twice per day (two in the morning and two in the evening). Benfotiamine need not be taken with meals. Some people get better results increasing the dosage to 900mg or 1200mg per day after the first two weeks. The point here is that benfotiamine is safe at any reasonable daily usage level. An individual should merely find the level that produces the maximum beneficial effect without reaching a point of diminishing return beyond which the excess amount is wasted.

Some case studies have documented daily usage in the 600mgday range and more with interesting anecdotal and clinical results: Holladay Case Studies.

Also, Dr. Brownlee participated in a clinical trial using 600mg/day: Clinical Trial Using 600mg with dramatic results after increasing daily usage to 600mg. The neuropathy symptoms ceased progression and began to reverse and people experienced a complete cessation of sciatica episodes. Also, the average blood pressure dropped from a persistent 145/90 to 120/80, without the use of other blood pressure medications.

Most people get excellent results in 14-21 days using two 150mg???!!!! How do I get a hold of this stuff?

I’m really disapointed that the naturopath didn’t mention this. I’ve been taking B Complex for so long now with very little results, you’d think she could’ve at least mentioned that there are fat soluble vitamins. She seemed more interested in talking about me in her class.

I don’t really think she did enough reading or understanding of my symptoms. It’s really hard to knock what she was doing because she gave me two suppliments that have helped me tremendously but there comes a point where you say: “This is not working.” The acupuncture doctor did that and I’ll give her the most credit for helping me figure out my symptoms and leading me on my current path to understanding the root cause even though it had nothing to do with acupuncture.

I’d love to go back to her one day not for a treatment, but to tell her all about my discoveries since I stopped the acupuncture. I’d love to see her do the cupping with no pepperoni marks and watch as my blood pressure reads normal. That would be great and maybe someday I’ll see her for another appointment. Imagine if the results came back  and I could tell her that I have Beriberi? She won’t believe it and neither will anybody else.

June 21, 2006 - Posted by | Health | , , ,

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